University of Michigan

Targeting food addiction through an intensive energy-reduced Mediterranean diet lifestyle intervention: evidence from the 3-year PREDIMED-plus trial

Food addiction (FA) has been proposed as a behavioural phenotype linked to obesity, potentially influencing adherence and response to lifestyle interventions. Its role within long-term, multicomponent weight-loss programmes remains unclear. This study evaluated the impact of an i...

Shadows cast by precessing annuli as evidence for an inclined planet in HD 139614

Abstract We analyse scattered-light images at multiple epochs of the protoplanetary disc HD 139614 taken with GPI and SPHERE instruments. We show that the azimuthal distribution of the surface brightness of the inner bright ring (13 − 21 au) varies with time (likely caused by a s...

Lung Function–Associated Genetic Variants and Overall Survival in Non–Small Cell Lung Cancer: A Multi-Platform Analysis

Abstract Background: Genome-wide association studies (GWAS) have identified numerous variants associated with spirometric lung function, and Mendelian randomization studies suggest that impaired pulmonary function contributes to lung cancer susceptibility. Whether these variants...

Catheter-Associated Urinary Tract Infection Prevention Practices in US Hospitals

Importance Catheter-associated urinary tract infection (CAUTI) remains a common and morbid health care–associated infection. Although evidence-based prevention strategies are well established, the degree to which hospitals adopt and sustain these practices over time and whether t...

Anticoagulation Treatment Response Among Phenotypic ESUS Clusters: Evidence From CASPR

ABSTRACT Objective To evaluate treatment effect heterogeneity across phenotypic clusters of patients with cryptogenic embolic stroke using causal inference methods. Methods From a retrospective, multicenter cohort of patients with cryptogenic embolic stroke, we estimated the trea...

Advances in isothermal nucleic acid amplification-based HPV assays for cervical cancer screening in low- and middle-income countries: A scoping review

Objective Cervical cancer disproportionately affects low- and middle-income countries (LMICs), where over 90% of deaths occur and where cost, infrastructure, and low acceptability impede the WHO 2020–2025 goal of elimination by 2030. This review synthesizes advances in isothermal...

GSTT2 Switches from a Homeostatic Antioxidant to a Cell-Cycle-Coupled Factor in Therapy-Resistant Esophageal Adenocarcinoma

Background/Objectives: Glutathione S-transferase theta 2 (GSTT2) is highly expressed in esophageal tissues from African American (AA) compared with European American (EA) individuals, but its localization, regulation, and relevance to esophageal adenocarcinoma progression remain...

Prognostic implications of complications during VA-ECMO for cardiogenic shock

PURPOSE: Veno-arterial extracorporeal oxygenation (VA-ECMO) provides comprehensive cardiopulmonary support in patients with cardiogenic shock (CS), but may result in complications. While complications rates are known, their impact on risk of death remains largely unknown. METHODS...

Moving omics methods beyond the bench to tackle urgent challenges facing the water industry

Advances in multi-omic sequencing have revolutionized our understanding of the composition and potential function of genetic sequences across human, natural, and engineered systems. However, while advancements in omics methods have transformed the medical industry through patient...

Lifetime prevalence of self-reported defensive gun use, offensive gun use, and nonfatal firearm victimization among Michigan adults

Abstract Background While guns have significant cultural importance in the United States, guns are also used in crimes and in self-defense and so many Americans will have experiences with guns that involve fear, property loss, or injury. To better inform firearm policy, we estima...

Temporal proximity to counseling is associated with longitudinal bedaquiline and antiretroviral therapy adherence in multidrug-resistant tuberculosis and HIV treatment

Background Medication adherence is a persistent challenge in the treatment of multidrug-resistant tuberculosis (MDR-TB) and HIV. Routine counseling notes are an underutilized source of information on patient adherence context. Methods We applied natural language processing (NLP)...

Maintaining cognitive gains in type 2 diabetes: Barriers, supports, and patterns of strategy use

In this study, we report how adults with type 2 diabetes maintained cognitive strategies learned in the Memory, Attention, and Problem-Solving Skills for Diabetes (MAPSS-DM) intervention. We identify three patterns of strategy maintenance that emerged from follow-up interviews wi...

Registering A Company [Some Countries of Interest]

We are investigating how to register a company. Many options and countries are of interest (some examples are given).

Low-dimensional Galerkin projection models for predicting turbulent secondary mean flow in a square duct

The presence of sidewalls in turbulent duct flows leads to the emergence of secondary flow structures in the form of counter-rotating streamwise vortices near the corners (Prandtl’s secondary flow of the second kind). This work develops reduced-order Galerkin projection models th...

Outcome-as-a-service for multi-objective Dask-based Earth Observation processing

Distributed Earth Observation (EO) workflows require cluster configurations that balance competing objectives (execution time, computational cost, energy consumption, and resource-use efficiency), yet practitioners typically provision resources using fixed heuristics that ignore...

Single-Atom Modification Enables Reversal of Degradation Selectivity between NSD2 and GSPT1

Abstract Both NSD2 and GSPT1 represent compelling targets for anticancer drug discovery. Herein, we carried out single-atom modification of LLC0424, an NSD2 degrader with GSPT1 neosubstrate engagement, to yield two structurally analogous molecules with divergent modes of action:...

How content sophistication shapes climate discourse on YouTube

We analyze 3163 climate-related YouTube videos posted between 2006 and 2021. More sophisticated videos—those with higher production quality, richer descriptions, longer duration, and specialized terminology—draw climate-related comments that lean toward explicit position-taking a...

Registering A Company [Some Countries of Interest]

We are investigating how to register a company. Many options and countries are of interest (some examples are given).

Registering A Company [Some Countries of Interest]

We are investigating how to register a company. Many options and countries are of interest (some examples are given).

Registering A Company [Some Countries of Interest]

We are investigating how to register a company. Many options and countries are of interest (some examples are given).