University of Michigan

A causal machine learning framework for treatment personalization in clinical trials: application to ulcerative colitis

Randomized controlled trials estimate average treatment effects, but treatment-response heterogeneity motivates personalized approaches that identify which patients benefit most from specific interventions. Causal machine learning methods offer a principled framework for estimati...

AI LEGO: Scaffolding Cross-Functional Collaboration in Industrial Responsible AI Practices during Early Design Stages

Responsible AI (RAI) efforts increasingly emphasize the importance of addressing potential harms early in the AI development lifecycle through social-technical lenses. However, in cross-functional industry teams, this work is often stalled by a persistent coordination challenge:...

A Scoping Review of Queer Health and Well-Being Technology Research

Technology has and will continue to have a significant impact on queer people’s health and well-being; however, it is not guaranteed that these implementations lead to meaningful advancements. Through a scoping review of 69 queer health technology papers in the ACM Digital Librar...

Post-Post-API Age: Studying Digital Platforms in Scant Data Access Times

Over the past decade, data provided by digital platforms has informed substantial research in HCI to understand online human interaction and communication. Following the closure of major social media APIs that previously provided free access to large-scale data (the “post-API age...

Improving Medication Classification in GLP‐1RA Research: Feasibility of a Photo‐Review Protocol

ABSTRACT Objective Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) are dominating the type 2 diabetes and obesity intervention landscape, yet their real‐world use is increasingly difficult to characterize amid widespread availability of non–FDA‐approved, compounded products...

Engineered pediatric human muscle models the interferon-driven transcriptome of juvenile dermatomyositis

Abstract Juvenile dermatomyositis (JDM) is a rare pediatric autoimmune disease characterized by a strong type I interferon (IFN) signature in muscle. Mechanistic and therapeutic discovery has been limited by the lack of a clinically relevant disease model. To address this, we tes...

Effect of In-line Clinical Decision Support to Improve Accuracy of American Society of Anesthesiologists Physical Status Documentation: A Two Center Evaluation of a Quality Intervention

Background: American Society of Anesthesiologists Physical Status (ASA PS) classification is a widely used ordinal scale that captures comorbidity burden but has significant inter-rater variability. Previous efforts to enhance ASA PS documentation with Clinical Decision Support (...

A Heavy Traffic Theory of Matching Queues

Motivated by emerging applications in online matching platforms and marketplaces, we study a matching queue. Customers and servers that arrive in a matching queue depart as soon as they are matched. It is known that a matching queue without an external control is unstable, and so...

CARINA: Carbon-Aware Execution of Recurrent Industrial Analytics

Recurring industrial analytics and machine-learning workflows are becoming a major computational burden in modern engineering practice. Large parametric database generation, scheduled model retraining, repeated evaluation pipelines, and extensive hyperparameter exploration can de...

Zero-Waiting Load Balancing with Heterogeneous Servers in Heavy Traffic

We study the steady-state delay performance of load balancing in large-scale systems with heterogeneous servers in the heavy-traffic regimes. The system consists of N servers, each with a local buffer of size b − 1, serving jobs in the first-in-first-out (FIFO) order. Jobs arrive...

Characteristics and dietary practices among adults with experience following a ketogenic diet in Saudi Arabia: a cross-sectional study

The ketogenic diet (KD) has gained substantial popularity worldwide, particularly as a strategy for weight loss and metabolic health. Although previous studies have examined public knowledge and perceptions of the KD, little is known about the knowledge, dietary practices, and ad...

Conserved C-terminal residues adjacent to the canonical PDX1 homeodomain are required for chromatin occupancy and pancreas development

Essential roles for the PDX1 transcription factor in pancreatic development and β-cell function are well-known, yet the structure-function relationships of domains within its C-terminus remain incompletely defined. We identified a focal intrinsically disordered region (IDR) spann...

STRUCTURED LIFE COURSE ANALYSIS OF DNA METHYLATION ASSOCIATIONS WITH INTERNALIZING BEHAVIOR AND ANXIETY FROM AGES 3-22

Mental health challenges often emerge early in development, with childhood and adolescence representing key periods of vulnerability. Internalizing symptoms, which include anxious and depressive symptoms, are among the most common psychological difficulties in youth and are typic...

Estimating Daily Taxon-Specific Tree Pollen at a 1-km Resolution in Atlanta, GA from 2020 to 2024

Abstract While tree pollen is a major trigger of respiratory allergies, the lack of high-resolution, taxon-specific exposure data has limited our ability to identify local taxa. Traditional pollen monitoring networks rely heavily on human efforts, thereby being limited to one sit...

High‐resolution spatial transcriptomic atlas of mouse soleus muscle: Unveiling single cell and subcellular heterogeneity in health and denervation

Skeletal muscle is essential for both movement and metabolic processes, characterized by a complex and ordered structure. Despite its importance, a detailed spatial map of gene expression within muscle tissue has been challenging to achieve due to the limitations of existing tech...

Utility and best practices for clinical diagnostic testing of the autonomic nervous system: A Consensus Statement Endorsed by the American Autonomic Society and the American Association of Neuromuscular & Electrodiagnostic Medicine

Abstract Purpose Disorders of the autonomic nervous system are prevalent and associated with substantial morbidity, mortality and diagnostic delay. Standardized, laboratory-based autonomic function testing provides objective physiological data essential for diagnosing, staging, a...

Emerging deployment of Engineered Cementitious Composites (ECC) for durable and resilient bridge infrastructure

Abstract Modern bridges are faced with lifecycle challenges of ensuring safety and durability under the combined exposure to traffic and environmental loadings. As an emerging high-performance material, Engineered Cementitious Composites (ECC) possesses ultrahigh tensile ductilit...

The End of Science? Agnosis and American Fascism

The Society for Social Studies of Science (4S) annually awards the John Desmond Bernal Prize to one or more individuals who have made distinguished contributions to the field of Science and Technology Studies. Past winners have included founders of the field, along with outstandi...

Building a Stack for Systems Deployment

We are introducing few lines of methodology to start building Models & Systems for Deployment. We start first with Asana Platform and the Automated Fact-Checker [here]. More Collaboration Invitation will be sent to participate in the project.

Building a Stack for Systems Deployment

We are introducing few lines of methodology to start building Models & Systems for Deployment. We start first with Asana Platform and the Automated Fact-Checker [here]. More Collaboration Invitation will be sent to participate in the project.