University of Michigan

Letter to University of Montreal – Address to Our Supervisors Team

In this paper, We are addressing a note to University of Montreal, mainly our Supervisors : Professor [bilodeau@dms.umontreal.ca],Professor [duchesne@dms.umontreal.ca], and Professor [murua@dms.umontreal.ca], Professor Perron [perronf@dms.umontreal.ca],Professor David [dhaziza@uo...

Risk assessment of driver emotion using a data-driven Bayesian Network: Insights from a naturalistic driving study

Introduction: Driving in a state of high emotions, particularly anger, can impair driving abilities and increase the risk of crashes. Understanding the influencing factors on emotions and how emotions impact safety–critical events (SCEs) is crucial for enhancing traffic safety. T...

Letter to University of Montreal – Address to Our Supervisors Team

In this paper, We are addressing a note to University of Montreal, mainly our Supervisors : Professor [bilodeau@dms.umontreal.ca],Professor [duchesne@dms.umontreal.ca], and Professor [murua@dms.umontreal.ca], Professor Perron [perronf@dms.umontreal.ca],Professor David [dhaziza@uo...

Regulation of alanine glutamine asparagine catabolism is common to mouse models that extend lifespan

Previous work has shown that three interventions that extend mouse lifespan (acarbose, canagliflozin, or calorie restricted diet) as well as two genetic models (Snell and GHRKO) down-regulate MEK1-ERK and mTOR signaling and activate chaperone-mediated autophagy. Because of the co...

A filtered mapping cone formula for cables of the knot meridian

We construct a filtered mapping cone formula that computes the knot Floer complex of the (n,1) -cable of the knot meridian in any rational surgery, generalizing Truong’s result about the (n,1) -cable of the knot meridian in large surgery and Hedden–Levine’s filtered mapping cone...

Bayesian variable selection on small sample trial data via adaptive posterior-informed shrinkage prior

Identifying variables associated with clinical endpoints is a central objective in clinical trials. With the rapid expansion of cell and gene therapies (CGTs) and therapeutics for ultra-rare diseases, there is an urgent demand for statistical methods capable of detecting meaningf...

Geometry-controlled instability pathway selection in elastic helices enables fast, efficient robotic locomotion

Mechanical instabilities can convert slow actuation into rapid, amplified motion, but predicting whether a three-dimensional elastic structure buckles smoothly or snaps remains challenging. Here, we show that helix geometry and boundary loading jointly select continuous buckling...

Influence of Stress Path and Particle Quantity on Granular Soil Critical State and Fabric: Insights from DEM Simulations

Abstract Critical-state soil mechanics provides a fundamental framework for describing the shearing behavior of granular materials. This study employs the discrete-element method (DEM) to investigate the critical-state behavior of granular materials under direct shear, direct sim...

Functional analysis of the methanobactin-encoding gene cluster of Methylocystis sp. strain SB2

ABSTRACT Methanobactins (MBs) are ribosomally synthesized, post-translationally modified polypeptides that have high binding affinities for copper. The key step for post-translational modification of the MB polypeptide precursor is the formation of two heterocyclic rings (pyrazin...

Trends in trajectories and incidence of functional impairment in middle-aged Americans

The prevalence of functional impairment (i.e., difficulty performing daily activities such as bathing and dressing) has increased among middle-aged Americans, but longitudinal data are lacking. The objective of this study was to examine trajectories of functional status and incid...

Experimental versus clinical studies capture distinct types of relapse in tuberculosis

(Mtb) currently infects a quarter of the world's population. Though many TB patients cure infection with short-course treatment, regimens shorter than 4 months risk post-treatment relapse. This is facilitated by the presence of granulomas, spatially heterogeneous immune structure...

Institutional Post-Acute Care Use After Hospitalization by Medicare Type, 2017-2022

Objectives To compare national discharge to inpatient rehabilitation facilities (IRF) and skilled nursing facilities (SNF) after short-stay hospitalization among Medicare Advantage (MA) and Traditional Medicare (TM) beneficiaries. Design Retrospective cohort study using publicly...

Trends in Pediatric Urology Resident Operative Exposure and Autonomy: An 11-Year National Study

PURPOSE: Fewer urology residents are pursuing pediatric urology fellowship. Studies have examined potential associations between surgical residents' operative experience, autonomy, and exposure and fellowship pursuit. This relationship has not been examined with respect to pediat...

Leakage Correction Cross-Section for Axial Void Channels in the 2D/1D Method

A new leakage correction method is proposed to improve the accuracy and stability of 2D/1D transport calculations, especially for designs with large void channels. The approach introduces a leakage correction cross-section that increases neutron collisions in void regions, thereb...

Media Use, Viewing Women as Sexual Objects, and Rape Myth Acceptance Among U.S. College Women

Heavier media exposure is associated with greater rape myth acceptance; one explanatory mechanism proposed is the sexual objectification of women. Sexually objectifying content is prevalent in mainstream media, and embracing this perspective of women is linked to dehumanization a...

Typifying tiny teeth: A standardized coding system to quantify morphological variation in fish teeth for comparative ecological, evolutionary, and functional morphological studies

Abstract Teeth play a crucial role in vertebrate ecology as one of the main interfaces between predators and their prey. As the most diverse vertebrates on the planet, and the dominant vertebrate consumers in nearly all aquatic ecosystems, fishes – and their teeth – thus play an...

Simple a posteriori insertion of fossil tips in molecular phylogenies can improve inferences of continuous trait evolution

Abstract Integrating neontological and paleontological information improves inferences about the tempo and mode of phenotypic evolution over long timescales. However, outside a few exemplar clades, morphological matrices establishing formal phylogenetic placements of fossils with...

Large‐scale nuclear and plastid phylogenomic analyses inform an updated Angiosperm Phylogeny Group classification: APG V

Abstract We present here a revision of the APG classification that considers the extensive recent analyses of hundreds of nuclear and plastid genes for many angiosperm species. Although previous versions of the APG classification were largely based on uniparentally inherited mark...

Margin Assessment in Breast-Conserving Surgery: A Comparative Analysis of Frozen Section and Cavity Shave Techniques

Abstract Background Margin status is a critical determinant of local recurrence after breast-conserving surgery (BCS). Achieving negative margins at the initial operation remains a key goal to optimize oncologic outcomes and minimize the need for additional surgery. Techniques to...

The Effect of Post-Traumatic Stress Disorder on Total Shoulder Arthroplasty Outcomes: A Retrospective Cohort Study

Background: Total shoulder arthroplasty (TSA) continues to have increased use, and about 6 out of every 100 individuals are diagnosed with post-traumatic stress disorder (PTSD). Previous studies have shown that PTSD affects bone health and joint arthroplasty outcomes. Although bo...