University of Michigan

Extracellular Vesicles, Exosomes, and Cancer: Detection and Therapeutic Monitoring

Abstract Extracellular vesicles (EVs) are membrane-bound vesicles released by cells into the extracellular space. Exosomes are a nanoscale subtype of extracellular vesicles (typically 30–200 nm) secreted by almost all types of cells. They carry a diverse molecular cargo, includin...

The essential and Cremona dimensions of a group

The Cremona dimension of a group G is the minimal n such that G is isomorphic to a subgroup of the Cremona group of birational transformations of an n -dimensional rational variety. In this survey article, we give many examples that give evidence to the conjecture that the Cremon...

Vasoconstrictor therapy for HRS-AKI in patients listed for liver transplantation: Translating evidence to the pretransplant setting

Hepatorenal syndrome-acute kidney injury (HRS-AKI) is a life-threatening complication of decompensated cirrhosis and carries significant implications for liver transplantation (LT) candidacy and outcomes. Terlipressin, a synthetic vasopressin analogue, has emerged as a first-line...

Linking social attention to reproductive state and future reproduction in female monkeys

Abstract The demands of complex social life are thought to drive the evolution of cognition in primates. One important approach to testing this hypothesis is to assess if variation in psychological processes impacts an individual’s fitness outcomes, but this can be challenging in...

Foreign Coins in Hebrew Gold: Yaakov Fichman and the Gendered Economics of Translation

In the first decades of the twentieth century, Hebrew writers and thinkers debated the topic of translation, considering the necessity for and best methods of translation into Hebrew. This essay explores writings by the poet and translator Yaakov Fichman, alongside those of his c...

Leptin-sensitive hypothalamic Lepr+/Glp1r+ neurons limit hyperphagia and weight gain in diet-induced obesity

Abstract Despite loss of responsiveness to exogenous leptin in obesity, endogenous leptin continues to restrain feeding, although the neural substrates that remain sensitive and mediate this effect remain unknown. Combining spatial transcriptomics with single-nucleus RNA sequenci...

Comparative Analyses of the Type D ASEP: Stochastic Fusion and Crystal Bases

The Type D asymmetric simple exclusion process (ASEP), a particle system involving two classes of particles, was studied from both probabilistic and algebraic perspectives by Kuan et al. (2022). From a probabilistic perspective, we perform stochastic fusion on the Type D ASEP int...

Chemoenzymatic Synthesis of ( E,E,Z )-Humulene-Derived Natural Products

Abstract Meroterpenoid natural products derived from the 11-membered macrocycle humulene are of great interest due to their potent biological activities and intricate architectures. Whereas molecules derived from the most available (E,E,E)-humulene isomer have been thoroughly inv...

The landscape of allele-specific expression in human kidneys

Allele-specific expression (ASE), the preferential expression of one gene copy, is a key mechanism of genomic regulation. However, its role in human kidney disease remains poorly understood. In this study, we generated a high-quality, genome-wide ASE map using paired whole-genome...

Bigger between-language than within-language Stroop effects in young and older deaf American Sign Language-English bilinguals

OBJECTIVE: The present study investigated Stroop interference effects in young adult and older deaf American Sign Language (ASL) and English bilinguals with ASL and English stimuli. METHOD: Deaf ASL-English bilinguals (n = 108; aged 21-88) signed their responses in two computeriz...

A multicenter multistate modeling on the natural history of liver decompensation: Longitudinal analysis of 1777 patients.

BACKGROUND: Cirrhosis often remains silent until decompensation, after which survival deteriorates sharply. Contemporary, transition-aware estimates are limited, especially in Asian-predominant cohorts. We analyzed trajectories from compensated advanced chronic liver disease (cAC...

The Impacts of Marijuana Usage on Nerve Transfer Outcomes: A Retrospective Cohort Study.

BACKGROUND AND OBJECTIVES: Marijuana is often used by patients with peripheral nerve injuries for pain management, but its impact on nerve transfer surgery outcomes remains unexplored. METHODS: tests and analysis of variance. RESULTS: = .01). CONCLUSION: In patients undergoing ra...

Mild alkaline phosphatase elevation associates with increased mortality and major adverse liver outcomes in MASLD.

BACKGROUND: Alkaline phosphatase (ALP) elevation is commonly observed in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), but its clinical implications in MASLD are unclear. We evaluated whether longitudinal patterns of mild ALP elevation are associ...

The DESI Y1 RR Lyrae Catalog. I. Empirical Modeling of the Cyclic Variation of Spectroscopic Properties and a Chemodynamical Analysis of the Outer Halo

Abstract We present the catalog of RR Lyrae stars (RRLs) observed in the first year of operations of the Dark Energy Spectroscopic Instrument (DESI) survey. This catalog contains 6240 RRLs out to ∼120 kpc from the Galactic center and over 12,000 individual epochs with homogeneous...

Hierarchical resonators for localized charging in room-scale magnetoquasistatic wireless power systems

Abstract Magnetoquasistatic wireless power transfer can deliver substantial power to mobile devices over near-field links. Room-scale implementations, such as quasistatic cavity resonators, extend this capability over large enclosed volumes, but their efficiency drops sharply for...

The Childhood Liver Disease Research Network's prospective characterization of pediatric primary sclerosing cholangitis.

BACKGROUND: Primary sclerosing cholangitis (PSC) is a rare biliary fibrosing disease that leads to significant morbidity and the need for liver transplantation. The Childhood Liver Disease Research Network is conducting a prospective, observational longitudinal study to define th...

Viscosity and Minimax Solutions for Path-Dependent Hamilton–Jacobi Equations in Infinite Dimensions and Related Differential Games

Abstract We establish new results for path-dependent Hamilton–Jacobi equations with nonlinear monotone, and coercive operators on Hilbert space, which were initially studied in Bayraktar and Keller [2]. Under more general assumptions than in the cited paper (and more general than...

The DESI Y1 RR Lyrae Catalog. II. The Metallicity Dependency of Pulsational Properties, the Shape of the RR Lyrae Instability Strip, and Metal Rich RR Lyrae

Abstract RR Lyrae stars (RRLs) are valuable probes of both Milky Way assembly and stellar-evolution physics. Using a sample 6240 RRLs obtained in the first year of the Dark Energy Spectroscopic Instrument (DESI) survey, we investigate the metallicity of RRLs and its correlation w...

Grief in Neurosurgery: Reframing Loss and Identity Through Lived Experience.

Grief is an under-recognized yet pervasive experience in neurosurgery, arising not only from the death of patients and loved ones but also from losses related to professional identity, health, and personal relationships. Despite its relevance, grief is often conflated with burnou...

Enhancing FAIR data practices in China: An integrated strategy for biomedical research

The construction of scientific data compliant with FAIR (Findability, Accessibility, Interoperability, and Reusability) principles has become a consensus in the biomedical field. However, FAIR is often implemented at the data submission stage, leading to suboptimal outcomes, such...