University of Michigan

Exercise as a Complementary Intervention for Adults with Attention Deficit Hyperactivity Disorder: A Neurobiological Analysis

Objective: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention and/or hyperactivity-impulsivity that interferes with functioning or development. Stimulant medication remains its first-line treatment, but perceiv...

Diagnostic advantages of local versus nonlocal definitions of uropathogenic E. coli (UPEC) in semi-rural Ecuador

Urinary tract infections (UTIs) are among the most common outpatient morbidities globally and can progress to invasive infections, including sepsis. Uropathogenic Escherichia coli (UPEC) is the most common cause of UTIs and third-generation cephalosporin-resistant (3GCR) UPEC are...

“…If the Doctor Didn't Suggest it, Then I Would Probably Push the Idea Farther in My Head.”: Centering the Diverse Voices of Black Women to Understand PrEP Awareness and Access in the United States South

CONTEXT: In Atlanta, Georgia Black women account for most of new HIV diagnoses among women and 30% of Black women may benefit from pre-exposure prophylaxis (PrEP). Yet their PrEP knowledge, awareness, and access are low. METHODS: This study centers the voices of an economically d...

Challenges in establishing epidemiological cut-off values for the Burkholderia cepacia complex

ABSTRACT The Burkholderia cepacia complex (BCC) is comprised of 24 species of gram-negative bacteria that cause opportunistic infections. While antimicrobial susceptibility testing (AST) has historically been used to guide treatment for BCC infections, recent work highlighting pr...

Optical microscopy predictions of focal recurrence in glioblastoma

A hallmark of glioblastoma (GBM) is disease recurrence that occurs in all patients despite resection, radiation, and chemotherapy. A critical challenge in GBM treatment is the management of recurrent disease for which no standard of care exists. Predicting the location of GBM rec...

Many-to-one mapping of locomotor mode: a case study in the pelvic morphology of two basal hyaenodonts

Abstract Extant carnivorans are often used as ecological analogs for hyaenodonts because of their similar size and diet. However, it is unclear whether this comparison extends to locomotor mode. Unlike carnivorans, hyaenodonts have relatively short limbs and revolute lumbar artic...

Safety and Efficacy of Left Atrial Ablation After Percutaneous Left Atrial Appendage Occlusion in High-Bleeding-Risk Patients with Atrial Fibrillation: A Multicenter Analysis from the PROCEED-AF Ablation Registry

BACKGROUND AND AIMS: Patients with left atrial appendage (LAAO) devices are increasingly referred for AF ablation, yet anticoagulation strategies remain uncertain. The goal of this study was to evaluate the safety and efficacy of catheter ablation for atrial fibrillation (AF) in...

Application to Dalhousie University September 2026 : A Quick Note About Information System Classifications

We have started an Application into The Dalhousie University English Program. We notice for the first time a very intelligent information system. Some documents that we did save in our Google Drive Account [but not published elsewhere*] have contributive value in the system. As f...

Evolution of Mycobacterium tuberculosis Population Structure in Arkansas, 2009–2022, and Its Public Health Implications

The evolution of the Mycobacterium tuberculosis (M.tb) population structure in each population over time can help elucidate the drivers of tuberculosis (TB) epidemics. However, few previous studies have examined recent changes in M.tb population structure in low-incidence setting...

Long-term reprogramming of classical monocytes with altered ontogeny mediates enhanced lung injury in sepsis survivors

Patients who survive sepsis are predisposed to new hospitalizations for respiratory failure, but the underlying mechanisms are unknown. Using a murine model in which prior sepsis predisposes to enhanced lung injury, we previously discovered that classical monocytes persist in the...

Early metal-enriched baryon cycling before the midpoint of cosmic reionization

Abstract Models predict that chemical enrichment and gas redistribution should begin rapidly once star formation starts, but direct constraints at the earliest epochs have been scarce. Here we show that metal-enriched gas in multiple ionic phases was already present around galaxi...

How Many PM2.5 Sensors are Needed to Estimate Daily and Annual Deployed-Network Mean Concentrations in City-Scale Sensor Networks?

Abstract Low-cost PM2.5 sensors make it possible to deploy dense networks, but the density required depends on the monitoring objective and local variability. We examined how well smaller subnetworks reproduce deployed-network daily and annual or study-period mean concentrations...

A new half-life for 146Sm: Implications for lunar chronology

The timescales and mechanisms of early mantle-crust differentiation on the terrestrial planets and the Moon are often investigated using the 146 Sm- 142 Nd chronometer. Ages derived for the formation of lunar basalt source regions from this system based on the traditional 103 Ma...

Reporting Non-Consensual Intimate Imagery: An Audit Study of Deepfakes

Non-consensual intimate imagery (NCII) inflicts significant harm. Currently, victim-survivors can use two mechanisms to report NCII online—as a non-consensual nudity violation or as copyright infringement. We conducted an audit study of takedown speed of NCII reported to X (forme...

A causal machine learning framework for treatment personalization in clinical trials: application to ulcerative colitis

Randomized controlled trials estimate average treatment effects, but treatment-response heterogeneity motivates personalized approaches that identify which patients benefit most from specific interventions. Causal machine learning methods offer a principled framework for estimati...

Exploring young adult cancer survivors’ perspectives on generative AI chatbots for symptom support

BACKGROUND: Young adult cancer survivors (ages 18-39) often experience persistent treatment-related symptoms that negatively affect daily functioning, psychosocial well-being, and quality of life, yet report unmet educational needs for symptom management. Generative artificial in...

A Scoping Review of Queer Health and Well-Being Technology Research

Technology has and will continue to have a significant impact on queer people’s health and well-being; however, it is not guaranteed that these implementations lead to meaningful advancements. Through a scoping review of 69 queer health technology papers in the ACM Digital Librar...

Design Principles to Promote Acid–Base Interactions with a Weak Second-Sphere Lewis Acid

Abstract Boronic esters such as BPin are underutilized in secondary-sphere chemistry due to their weak acidity. We report a design strategy to enable cooperative binding with a BPin-appended NHC scaffold. Employing a shortened tether enhances preorganization and facilitates subst...

Managing through Closed Loops: the (Im)Possibility of Scale in China's Data-driven Governance

This paper examines what we call the (im)possibility of scale in China’s data-driven governance: while the promises of volume and growth of data suggest the possibility of governance at scale, our ethnography shows that it is impossible to realize in practice. Instead, on-the-gro...

Enabling Sensitive Conversations with Consent Boundaries: Moa, a Platform for Discussing PhD Advising Relationships

When an individual is harmed by someone in power, such as a workplace manager, it can help to identify allies—people who would offer advice or supportive action. However, ally discovery is fraught because the very people who might be most relevant—e.g., someone who reports to the...