University of Michigan

Bayesian Ambiguity-Contraction-Based Adaptive Robust Markov Decision Processes for Adversarial Surveillance Missions

Collaborative Combat Aircraft (CCAs) are envisioned to enable autonomous intelligence, surveillance, and reconnaissance (ISR) missions in contested environments, where adversaries may act strategically to deceive or evade detection. These missions pose challenges due to model unc...

Machine Learning on Heterogeneous, Edge, and Quantum Hardware for Particle Physics

The next generation of particle physics experiments will face an era of challenges in data acquisition, due to unprecedented data rates and volumes along with extreme environments and operational constraints. Harnessing these data for scientific discovery demands real-time infere...

Joint Modeling of GD-1 and C-19 as Old Streams

Abstract DESI observational data for the GD-1 and C-19 streams are compared to stream simulations in an evolving multihalo potential of a Milky Way–like galaxy based on a cosmological Milky Way–like simulation. The number of subhalos decreases with time, and the subhalo-stream en...

Living With Known Unknowns: Prognostic Uncertainty in Congenital Cytomegalovirus Following Diagnosis

OBJECTIVE: To examine how parents experience and navigate prognostic uncertainty following a diagnosis of congenital cytomegalovirus (cCMV) and identify implications for clinical communication and newborn screening. METHODS: We conducted in-depth qualitative interviews with 41 bi...

Kynurenine Pathway Activation is Associated with Poor Sleep Efficiency in Men With HIV

Background: Sleep disturbances are common in people with HIV, yet the underlying biological mechanisms remain poorly understood. Chronic immune activation in HIV can induce the tryptophan-kynurenine (TK) pathway, which both reduces melatonin synthesis and increases production of...

Short Communication on Objects Found on Road

We have found some Objects on Road in Montreal City. Some Remarks are made.

Perceptions of Surgeons in Vietnam on International Medical Volunteers

Objective: Short-term surgical missions (STMs) have been used by various organizations to address gaps in the surgical workforce in low- and middle-income countries (LMICs). However, the literature is inadequate in documenting host communities' perceptions of STMs. We aimed to un...

Efficacy of Tenapanor in Patients With or Without Prior Use of IBS-C Prescription Medications: A Post-hoc Analysis of Phase 3 Clinical Trials

BACKGROUND: Tenapanor is approved for the treatment of irritable bowel syndrome with constipation (IBS-C) in adults. The impact of prior IBS-C prescription treatment(s) on the therapeutic efficacy of tenapanor is unknown. AIMS: To assess whether prior IBS-C prescription medicatio...

Pro-inflammatory and matricellular protein expression patterns associated with bronchopulmonary dysplasia severity

Abstract Background Pulmonary inflammation and dysregulated repair have been linked to the development of bronchopulmonary dysplasia (BPD), but disease severity varies widely, and the mechanisms leading to BPD heterogeneity remain unclear. We hypothesized that levels of pro-infla...

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

ABSTRACT Recent advancements in single‐cell RNA sequencing (scRNA‐seq) have greatly enhanced our ability to dissect cellular heterogeneity. However, unsupervised clustering often struggles to identify transitional or developmental boundary cells, as existing methods rely on highl...

The use of real‐world data in health services research for dementia care: A scoping review

Abstract Health services research (HSR) is critical to informing dementia care and often relies on real‐world data (RWD); however, RWD use in HSR has not been systematically mapped in the United States. Following previous researchers and Preferred Reporting Items for Systematic R...

Systemic RVX ‐208 Attenuates Experimental Periodontitis Through Inflammatory Host Modulation

AIMS: This study investigated whether systemic treatment of RVX-208, a selective BET protein inhibitor, could ameliorate experimental periodontitis in a prophylactic setting and examined transcriptomic changes associated with RVX-208 in vitro. METHODS: Porphyromonas gingivalis (P...

Prognostication in Amyotrophic Lateral Sclerosis: A Narrative Review of Pre-Diagnosis and Functional Outcomes

Amyotrophic Lateral Sclerosis (ALS) is a very heterogeneous disease, yet some of the most common questions received by physicians in the ALS clinic are “how much time do I have?” and “what can I expect to happen next?” This line of inquiry is not strictly limited to patients; cli...

Who is eligible for lung cancer screening, and where are they? National subpopulation estimates of people eligible for lung cancer screening

BACKGROUND: The utilization of lung cancer screening services is less than 20%. There are a myriad of barriers at the patient, provider, and health care system levels that account for such low uptake. One reason lung cancer screening rates remain low is that identifying who is el...

Primary Aldosteronism Severity Grading: Missing the Mark for the Moderate Majority

Elisabeth Ng, Adina F Turcu; Primary Aldosteronism Severity Grading: Missing the Mark for the Moderate Majority, The Journal of Clinical Endocrinology & Me

Cohomology of flag supervarieties and resolutions of determinantal ideals. II

We compute the coherent cohomology of the structure sheaf of complex periplectic Grassmannians. In particular, we show that it can be decomposed as a tensor product of the singular cohomology ring of a Grassmannian for either the symplectic or orthogonal group together with a sem...

Single-nucleus multi-omics reveals reversible molecular signatures in skeletal muscle of patients with heart failure with preserved ejection fraction

Heart failure with preserved ejection fraction (HFpEF) is a complex systemic syndrome characterized by severe exercise intolerance. In addition to cardiac dysfunction, abnormalities in peripheral skeletal muscle are key contributors to reduced exercise capacity in HFpEF. Multiple...

An analysis of emergency department visits for injuries among students at a large U.S. public university

Abstract Background Injuries are a significant source of morbidity and mortality among college students.While previous studies identified the most common causes of injuries among college students globally, none have examined electronic health record narratives through a qualitati...

Predicting the clinical course of advanced systemic mastocytosis on treatment with avapritinib or midostaurin

Abstract Advanced systemic mastocytosis (AdvSM) is driven by KIT D816V in approximately 95% of cases. Accurate assessment and prediction of clinical course and disease outcome before and during treatment with the KIT inhibitors midostaurin and avapritinib may facilitate optimizat...

Use of Anticoagulation Among Patients With Atrial Fibrillation or Atrial Flutter in the United States

BACKGROUND: Oral anticoagulation (OAC) remains underused in patients with atrial fibrillation or flutter at high risk of ischemic stroke. We aimed to characterize documented OAC prescribing at diagnosis and during 1-year follow-up and identify factors associated with baseline OAC...