University of Cambridge

Significant heat-transfer enhancement via polymer additives in two-dimensional sheared convection

Heat dissipation is critical in modern engineering and polymer additives offer a potential route to improve fluid-based cooling. We study elasticity-enhanced heat transfer in two-dimensional, thermally stratified Poiseuille flow. At Reynolds numbers italic Re less than or equival...

Knotless Suture Repair For Chronic Lateral Ankle Instability: A Systematic Review and Single-Arm Meta-Analysis

Introduction There is a need to assess the use of knotless sutures in cohorts with chronic ankle instability (CAI). Methods A literature search of Embase, Ovid MEDLINE, Cochrane Library and Scopus was conducted from each database’s inception to August 15, 2025. Eligible studies r...

Cell-intrinsic steroidogenesis regulates mast cell function

Steroid hormones are well-known regulators of mast cell function, but whether mast cells themselves produce steroids de novo and influences their effector function has remained unknown. Here, we show that mast cells constitutively express the steroidogenic enzyme cytochrome P450...

Heat treatment technique and fuelwood density shape silcrete flake-edge geometry

Silcrete heat treatment was a transformative technological innovation in the Middle Stone Age, enabling toolmakers to improve the flaking properties of this raw material. Recent research has highlighted that silcrete heat treatment is not a uniform process, different silcrete sou...

Innovation adoption across regions: psychological openness and the early diffusion of digital platforms

Early regional adoption is crucial for platform-enabled innovations because their viability depends on enough people within a region adopting them to generate network effects. Existing research on regional innovation diffusion explains early adoption largely through demographic,...

Leveraging Large Language Model Token Probabilities for Literature Review Abstract Filtering

Code for using LLMs to sort through literature review abstracts

A broad-host-range Rhizobium rhizogenes strain enables transient expression across diverse crop species

Agrobacterium -mediated transient expression has revolutionised plant research, enabling numerous landmark discoveries across diverse areas of plant biology. Yet this powerful approach remains largely confined to solanaceous species, leaving most economically important crop famil...

Coevolutionary attack and avoidance strategies in predators and grouping prey

Abstract The formation of groups by prey is one of the most widespread evolutionary responses to predation. However, while the anti-predation benefits provided to prey within groups have been extensively explored in the literature, the subsequent response of predators to grouping...

Biomechanical analyses point to dense collagen fibre architecture in an Ediacaran frond

Ediacaran macrofossils record the earliest large and complex organisms on Earth. Despite extensive study, fundamental aspects of their internal anatomy and tissue composition remain poorly known, limiting understanding of how these organisms were constructed and functioned, as we...

Recurrent neural chemical reaction networks trained to switch dynamical behaviours through learned bifurcations

Both natural and synthetic chemical systems not only exhibit a range of non-trivial dynamics, but also transition between qualitatively different dynamical behaviours as environmental parameters change. Such transitions are called bifurcations. Here, we show that recurrent neural...

Exploration of the genetic architecture of ANCA-associated vasculitis

Background Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a complex autoimmune disease with distinct clinical and serological subtypes. Previous genome-wide association studies (GWAS) have identified several susceptibility loci, particularly within the major h...

Molecular mechanisms underlying the effectiveness of triiodothyroacetic acid (Triac) in patients with resistance to thyroid hormone β (RTHβ): a multicentre, international, retrospective cohort study

Background Disease features in resistance to thyroid hormone beta (RTHβ), caused by THRB mutations, arise from insensitivity to thyroid hormone in tissues expressing thyroid hormone receptor (TR)β and from lifelong thyrotoxic effects in TRα1-expressing tissues, posing substantial...

Symplectic Neural Flows for Modeling and Discovery

Abstract. Hamilton’s equations are fundamental for modeling complex physical systems, where preserving key properties such as energy and momentum is crucial for reliable long-term simulations. Geometric integrators are widely used for this purpose, but neural network-based method...

Clinical outcomes of primary anterior cruciate ligament reconstruction with concomitant lateral meniscal posterior root tear repair versus isolated anterior cruciate ligament reconstruction: a systematic review and meta-analysis

Introduction Lateral meniscal posterior root tears (LMPRTs) commonly occur with anterior cruciate ligament (ACL) injuries, but clinical outcomes after concomitant repair remain unclear. Aim This systematic review and meta-analysis compared postoperative outcomes after ACL reconst...

Automated Roadside Vegetation Management Using LiDAR-Based Geospatial Simulations

Abstract Effective roadside vegetation management is vital for safety, visibility, and infrastructure longevity. Traditional methods are often labor-intensive, time-consuming, and difficult to scale. This paper presents a novel approach leveraging light detection and ranging (LiD...

Generalisability of an adult-trained AI model to paediatric coeliac disease diagnosis: a multicentre external validation study

Background Coeliac disease diagnosis on duodenal biopsies is limited by interobserver variability. We have previously demonstrated pathologist-level performance with our artificial intelligence (AI) model for the histopathological diagnosis of adult coeliac disease, but not in pa...

Readers of the Living: Interpretive Mastery and Natural Thinking in Plutarch, Celsus, Origen, and Porphyry

Abstract This article examines the intersection between imperial writings on animals and post-Hellenistic debates about exegesis. It is the first study to argue that interpreters drawing on Aristotelian theories of voice and Hellenistic ideas of natural sympathy treated the meani...

Connectivity‐Dependent Mechanics of Main‐Chain Oligomers in Side‐Chain Liquid‐Crystalline Polyacrylate Networks

ABSTRACT Liquid‐crystalline elastomers (LCEs) combine orientational order with polymer‐network elasticity, yet the influence of molecular connectivity on their mechanics across different timescales remains poorly understood. Side‐chain polyacrylate LCEs containing main‐chain liqu...

Heterochronicity shapes brain network formation

Brain network formation unfolds on a nonuniform developmental timetable, with different cortical regions generating connections at different developmental phases. Generative network models (GNMs) aim to uncover the principles underpinning the organization of connectomes by creati...

Organizational Zemblanity: How Organizational Learning Can Reinforce Rigidity, Error, and Misalignment

Organizational learning can help organizations improve and adapt, but it can also reinforce error and misalignment. These negative outcomes are often interpreted as implementation problems or as signs of incomplete learning. We instead examine the possibility that dysfunction can...