Institution
University of Cambridge
Recent research
- Physics & SpaceOpen access
<ns5:p>The distributed architecture of the SKA Regional Centre Network (SRCNet) aims to provide scientific communities worldwide with efficient computational and storage resources to exploit the massive data volumes produced by the SKA Observatory (SKAO). Given the amount of SKAO...
- Physics & SpaceOpen access
In Situ High Shear Perturbation of Surface MolecularLayers with Neutron Reflectivity
Abstract We present the effect of in situ imposed shear on two adsorbed molecular layers using a flow cell that enables access to shear rates of up to 2 × 105 s–1 (shear stress: 2 × 102 Pa). The response of these molecular layers to shear is determined by the relative strength of...
- Health & MedicineOpen access
Background Clozapine reduces overall mortality and suicide risk in schizophrenia, but the specific causes and clinical contexts of death among clozapine-treated patients remain less well characterised. Aims We aimed to characterise causes of death in clozapine-treated patients wi...
- Climate & EnvironmentOpen access
People, Pasture and Plant Use: The Environmental Archaeology of Helgusel Shieling Site, SW-Iceland
Shielings were a vital part of the agricultural system in Iceland for a millennium. They were sites of seasonal habitation where people brought domestic animals for grazing and to spare the infields for haymaking. In this paper, the site of Helgusel shieling in Mosfellsdalur is t...
- BiologyOpen access
Early Longitudinal Brain Network Changes in Huntington's Disease Before Clinical Motor Onset
Abstract Background Longitudinal studies of seed‐based functional connectivity (SBFC) in young adult Huntington's disease gene‐expanded (HDGE) individuals are rare, and none, to our knowledge, have examined adult cohorts decades from predicted clinical motor diagnosis. Objectives...
- Society & EconomicsOpen access
Transdiagnostic symptoms of psychopathology interact with changes in environmental uncertainty
Abstract Uncertainty is a potential driver of poor mental health outcomes, and uncertainty is mounting across domains of daily life. It remains unclear how symptoms of anxiety and depression emerge in response to uncertainty in real-life contexts. The current study investigated h...
- Engineering & TechnologyOpen access
Reflex Charging for Anion‐Derived Solid Electrolyte Interphase Formation
ABSTRACT Lithium (Li) metal offers exceptional energy density but suffers from unstable interphases that lead to dendrite growth and poor reversibility. Because the interphase is established during the earliest stages of operation, controlling its formation is critical for stabil...
- BiologyOpen access
Abstract N-acetyltransferase 10 (NAT10) is a multifunctional enzyme that harbors RNA acetyltransferase and RNA helicase domains and has emerged as a therapeutic vulnerability in solid and hematological malignancies. By coupling Proteolysis Targeting Chimera-mediated degradation o...
- Engineering & TechnologyOpen access
Reflex Charging for Anion‐Derived Solid Electrolyte Interphase Formation
ABSTRACT Lithium (Li) metal offers exceptional energy density but suffers from unstable interphases that lead to dendrite growth and poor reversibility. Because the interphase is established during the earliest stages of operation, controlling its formation is critical for stabil...
- Health & Medicine
Background: Young people with first-episode psychosis experience high rates of disruption in work and education and consistently describe vocational participation as a core priority of recovery. This meta-analysis aimed to evaluate the effectiveness of evidence-based intervention...
- Health & MedicineOpen access
Mapping basal ganglia circuitry in altered states of consciousness: from pathology to pharmacology
The precise neuromodulatory mechanisms underlying consciousness and its disorders, despite growing evidence in both animals and humans, remain poorly understood at the subcortical level. The basal ganglia, a key component of the cortico-basal ganglia-thalamo-cortical loop, are kn...
- BiologyOpen access
Abstract Although human pluripotent stem cells (hPSCs) can generate all tissues of the body, hPSCs in vitro frequently exhibit differentiation biases or failure that pose substantial challenges for disease modeling and regenerative medicine. The origins of these biases remain inc...
- Health & MedicineOpen access
Abstract Minimally invasive surgery (MIS) for spontaneous supratentorial intracerebral hemorrhage (sICH) includes endoscopic evacuation and catheter-based evacuation (aspiration or drainage ± thrombolysis), but comparative performance remains uncertain. We performed a systematic...
- Society & EconomicsOpen access
Abstract We present a scalable artificial intelligence (AI)-assisted framework for rapidly generating ‘pre-bunking’ articles against election misinformation. Our approach uses a stable template structure that, once finalized through human review, can be quickly adapted to counter...
- Climate & EnvironmentOpen access
The German media debate on taxing meat and other animal-based foods: a framing analysis
OBJECTIVE: Consumption of meat - red and processed meat in particular - exceeds recommended levels in most high-income countries. Higher taxes on meat have been proposed as a response, but have proven difficult to implement due to political controversy. We examined the role of fr...
- Physics & Space
The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...
- BiologyOpen access
BACKGROUND: National guidelines recommend English women between 30 and 49 years with moderate/high risk of breast cancer (BC) be offered screening and prevention interventions. Identification largely relies on family history-based criteria amongst women self-presenting in primary...
- BiologyOpen access
BACKGROUND: The National Institute for Health and Care Excellence (NICE) recommends that women at above-population-level risk of breast cancer (BC) are offered enhanced screening and risk-reducing interventions. Identification of these women largely relies on referral through pri...
- Health & Medicine
Low-risk pragmatic trials improve clinical services. Informed consent is gold standard to ensure ethical research. However, its implementation can impact participation of underserved groups who face disproportionate barriers around communication, health and research literacy, and...
- Climate & EnvironmentOpen access
The Past, Present, and Future of Online Biodiversity Knowledge Systems
In recent decades, the availability and accessibility of biodiversity data and the profusion of portals, tools, and platforms through which to utilize them have increased rapidly. This reflects the extensive variety of challenges biodiversity data are being used to address and th...