University of Cambridge

Effectiveness of Interventions for Reducing Loneliness Among Adult Cancer Survivors: A Systematic Review and Meta-Analysis

Background/Objectives: Loneliness in adult cancer survivors is a frequent and disruptive psychosocial sequela with important consequences for overall health. Psychosocial interventions designed to address this issue are crucial. This systematic review and meta-analysis aimed to e...

Conduits of confidence and doubt

Abstract Oreskes and Conway’s (2010) paradigmatic cases for agnotology show how misplaced doubt can be deliberately produced in the minds of one’s audience, even when everything one asserts is strictly true. This phenomenon is well captured by a Gricean framework that places stre...

TrackStudio: An integrated toolkit for markerless tracking

Markerless motion tracking has advanced rapidly in the past 10 years and currently offers powerful opportunities for behavioural, clinical, and biomechanical research. While several specialised toolkits provide high performance for specific tasks, using existing tools still requi...

Disentangling local adaptation and phenotypic plasticity in traits associated with altitude and temperature in widespread tropical butterflies

Climatic stratifications, in particular differences in temperature, occur along altitudinal clines. Understanding divergence across these regions can give insight into speciation and diversification, as well as how species may respond to climate change scenarios. Most past resear...

Ekhard Karl Hermann Salje

Abstract Ekhard Salje used minerals as a Petri dish for solid state physics. He contributed across a vast range of problems, many of which reached beyond mineral science. His work covered ferroelasticity, domain wall physics, polarons, superconductivity, phase transitions and ava...

Diffusion Anisotropy Predicts Directional Progression After Complete Resection of Frontal Glioblastoma

BACKGROUND AND OBJECTIVES: Despite complete resection of contrast-enhancing tumor, glioblastoma frequently progresses due to microscopic invasion beyond surgical margins. In frontal glioblastoma, functional tolerance of anterior and lateral regions enables consideration of supram...

Building multi-stable structures based on Baranov truss part III: limit point (dead-centre) detection in linkage mechanism and non-rigid motion paths computation

Abstract Part I established a bilateration-based framework for programmable multi-stability in Baranov trusses, showing how discrete geometric configurations can be transformed into stable equilibria through elasticity. Part II extended this foundation into a general design toolk...

The exceptional set of the Goldbach problem

Abstract We study the estimates for the number of exceptions to the representation of integers as the sum of at most two prime numbers. Most of this article is a survey that gives an overview of existing results. We begin with the legendary Hardy–Littlewood circle method and show...

Small modular reactors and our ecosystems – engagement, transparency & trust; summary of a workshop held at McMaster University, Canada

Purpose: Globally, governments are launching national programs, demonstration projects and industrial partnerships to bring small modular reactors (SMR) to market as lower-carbon, more flexible forms of nuclear power. Current international assessments suggest the first wave of co...

Lionel Vivian Crawford

Abstract Lionel Crawford made outstanding contributions to our knowledge of DNA tumour viruses. His work had profound impact on understanding how tumour viruses subvert the cells they infect and on identifying cellular proteins, encoded by tumour suppressor genes, that protect ce...

Antibody-drug conjugate engineering: from design to efficacy and safety

Antibody–drug conjugates (ADCs) represent a rapidly expanding class of targeted cancer therapeutics that combine the high selectivity of monoclonal antibodies with the potent cytotoxic activity of small-molecule drugs. Their clinical success relies on the simultaneous optimizatio...

Small hosts, big appetites: unveiling rapid and early low-mass black hole growth in cosmological zoom-in simulations of dwarf galaxies

Abstract Dwarf galaxies are ideal laboratories to probe the interplay between galaxy formation and the growth of black holes (BHs) in the early Universe. Mounting observational evidence reveals the presence of BHs in low-mass galaxies across cosmic time, with JWST uncovering a li...

The biogeography of giant viruses and interactions with Eukaryotes across European lakes

Abstract Advances in genomics have revealed a diversity of nucleocytoplasmic large DNA viruses (phylum Nucleocytoviricota) that infect eukaryotes, but their ecology beyond the oceans remains poorly understood. We recover 208 Nucleocytoviricota genomes, including 205 putative new...

The role of fenestration in acute canine thoracolumbar intervertebral disc extrusion: Part 2—The biological and biomechanical effects of fenestration

Abstract Background Prophylactic fenestration is widely performed to prevent recurrence of canine acute thoracolumbar intervertebral disc extrusion (IVDE); however, there is a paucity of specific data regarding the biological and biomechanical effect of this procedure on the inte...

Digital Twin-Enabled Vehicle Routing in Logistics and Transportation

Vehicle routing in modern logistics increasingly depends on live sensing: GPS and Internet-of-Things telemetry, roadside perception, and vehicle-to-everything (V2X) data streams change the operational state faster than static route plans can absorb. Digital twins have been propos...

Is uniformitarianism still necessary for studying Earth-like planets?

Hutton's uniformitarianism has been an instrumental concept in establishing Earth sciences as a rigorous discipline. However, ever since Gould's famous paper in 1965, we have been wrestling with whether the concept has largely outlived its scientific relevance. Here, I ask this q...

N,N-Dimethyltryptamine and harmine formulation alters transient EEG topography sequences near the peak of the psychedelic state

BACKGROUND: Psychoactive serotonin 5-HT2A receptor agonists are potent modulators of awareness. Influential theories propose that psychedelics alter whole-brain dynamics by increasing neural signal diversity and dynamic flexibility. Beyond temporal variability, it is an open ques...

Exposure to remote work and probability of long-distance commuting: evidence from pandemic lockdowns

Abstract In this paper, we investigate how the lockdown-induced exposure to remote work affected the likelihood of switching to longer commutes using a longitudinal full-population register of Swedish employees. We find that employees with little experience of longer commutes wer...

Sequential evaluation of a robotic dry-bone resection system using virtual model control with integral control: an exploratory benchtop study

Abstract Virtual model control (VMC) provides compliant trajectory execution, but sustained contact loads can produce residual positional error. This study evaluated the sequential development of VMC augmented with integral control for powered dry-bone resection and assessed the...

Cataract GWAS meta-analysis and multi-omics Mendelian randomisation inform disease mechanisms and candidate target prioritisation

Background Cataract is a highly prevalent cause of visual impairment and blindness worldwide. Although genome-wide association studies (GWAS) have mapped multiple cataract risk loci, further work is required towards translating these signals and integrating multi-omics evidence f...