University of Cambridge

Cataract GWAS meta-analysis and multi-omics Mendelian randomisation inform disease mechanisms and candidate target prioritisation

Background Cataract is a highly prevalent cause of visual impairment and blindness worldwide. Although genome-wide association studies (GWAS) have mapped multiple cataract risk loci, further work is required towards translating these signals and integrating multi-omics evidence f...

An additive reference correction scheme for the transcorrelated method

We introduce an additive reference correction for the transcorrelated (TC) method and its three-body mean-field approximation (xTC) to improve energy differences computed in small orbital basis sets. The correction is motivated by the observation that, for xTC atomization energie...

MATERIALITY AND HYLÊ IN LONGUS’ DAPHNIS AND CHLOE

Abstract This article reads the word ὕλη (‘woods’, ‘forest’) in the Greek novel Daphnis and Chloe as reflecting a philosophical tradition in which the word means ‘matter’. From Aristotle onwards, ὕλη gains the meaning of transformable matter, which admits fundamental changes of f...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

Integral modelling of weakly evaporating three-dimensional liquid film with variable-substrate heating

Analysing the dynamics of phase-changing liquid films is essential for enhancing the performance of thermal-management systems. Still, direct simulation of the full governing equations is computationally expensive. To circumvent this limitation, I derived a weighted-integral boun...

A GWAS META-ANALYSIS OF PSYCHOTIC DEPRESSION LEVERAGING HEALTH-RECORD, PRESCRIPTION AND SELF-REPORT DATA

Depression with psychotic features is poorly understood, and the extent to which its biology is shared with other psychosis disorders is unclear. There is evidence for a genetic basis for MDD, but there has not been a major GWAS of the phenotype. We are conducting the first GWAS...

Optically Tracked Reversible Single-Atomic-Monolayer Redox in Plasmonic Nanocavities

Abstract Controlling redox reactions at the atomic scale is key to enabling next-generation low-power memristive and neuromorphic devices. Ultrathin metallic layers, such as atomic monolayer palladium (Pd), offer tunable redox behavior well suited for switchable components in nan...

W5. DNA METHYLATION AS PROXY OF GENETIC AND PRENATAL PSYCHIATRIC RISK FACTORS

Background Genetic and prenatal risk factors contribute to neurodevelopmental conditions (NDCs). DNA methylation at birth may integrate their combined effects. Methods By leveraging data from two longitudinal birth cohorts, Generation R (Ntrain = 1856, Ntest = 476) and ALSPAC (Nv...

GPR35-positive mast cells are enriched in primary sclerosing cholangitis and show an enhanced secretory phenotype

OBJECTIVE: dependent mast cell biology relevant for cholangitis and biliary fibrosis. METHODS: knockdown were determined by DESeq2 and gene set enrichment analysis. Selected cytokines, TNFα and IL13, were measured by qRT-PCR and ELISA. Mast cell-cholangiocyte interaction was stud...

A cytogenetic analysis with chromosome painting in typical antbirds (Passeriformes, Thamnophilidae) and an inference on chromosome evolution in Passeriformes

Abstract The typical antbirds (Passeriformes, Thamnophilidae) are a monophyletic group comprising 225 species in 45 genera, primarily distributed in the lowland forests of the Neotropics. There is limited karyotypic information for this bird family, including chromosome morpholog...

Multimodal Perception through Synergistic Interface Fusion and Machine-Learning Decoupling in Vertically Integrated Flexible Sensors

Abstract Flexible integrated sensors have been constrained by signal crosstalk from planar layouts and material coupling, restricting the capability for high-precision multiparameter sensing. Here, we develop a biomimetic vertically integrated flexible sensor (BVIS) based on a po...

Power without Capacity? Despotic Centralism, Local Government, and the Contradictions of the English Council Tax Regime

The financing of English local government has become a critical aspect of centre-local relations during a period in which austerity has produced greater pressures on the former. The main means of funding local government is through Council Tax, a system of taxation based on resid...

Reciprocal connections dynamically build consensus between neocortical areas

Abstract The neocortex is organized into specialized areas. Although computations within individual areas have been well studied, it is unclear how these regions function collectively and reconcile potential conflicts to form coherent percepts and decisions. We investigated the j...

Self-Management as time management: exploring the temporal dimensions in school wellbeing discourses

This paper explores the role of temporal dimensions in shaping school-based wellbeing discourses, particularly emphasising self-management as a form of time regulation. It examines two prevalent discourses: achievement-driven temporal management and practices aimed at present-mom...

A Polynomial Improvement for the Odd Cycle–Complete Ramsey Numbers

Abstract We give a polynomial improvement to the cycle-complete Ramsey numbers $$\begin{aligned} r(C_{\ell },K_k) \geqslant k^{1+\frac{1}{\ell -2} + \varepsilon _{\ell } + o(1)}, \end{aligned}$$ r ( C ℓ , K k ) ⩾ k 1 + 1 ℓ - 2 + ε ℓ + o ( 1 ) , for all fixed odd $$\ell > 7$$ ℓ >...

Regularized interpolation in 4D neural fields optimizes geometric fidelity in 3D printing

While additive manufacturing (AM) enables unprecedented design freedom, process-induced geometric defects often limit its use in high-precision applications. Consequently, the ability to predict and correct these deviations by dynamically adjusting process parameters remains a cr...

BEFORE THE 1936 EXHIBITION: TENSIONS AND CONTRADICTIONS IN THE EXPORT OF ANTIQUITIES ON THE EVE OF THE KNOSSOS EXCAVATIONS

This paper revisits a seemingly straightforward question: why were the early excavations at Knossos not conducted under the auspices of the British School at Athens? It argues that a key factor lay in the exportation of antiquities, a practice with which the School was reluctant...

Workers shift their views and pay more when AI chatbots pander to their values

Abstract Large language models (LLMs) are increasingly embedded in knowledge work, raising the question to what extent they can systematically influence their users’ decisions—a question with commercial as well as societal stakes. Across an exploratory study and two pre-registere...

Nature‐Inspired Histidine and Guanidine Modification of Magnetic Nanoparticles for Urinary DNA Liquid Biopsy

ABSTRACT Urinary cell‐free DNA (cfDNA) is a promising substrate for non‐invasive liquid biopsy analysis and biomarker detection. However, the lack of standardized pre‐analytical workflows and the intrinsic challenges associated with isolating highly dilute and fragmented cfDNA li...

Lower Bounds for Set-Multilinear Branching Programs

Abstract. In this paper, we prove super-polynomial lower bounds for the model of sum of ordered set-multilinear algebraic branching programs, each with a possibly different ordering ([Formula: see text]). Specifically, we give an explicit [Formula: see text]-variate polynomial of...