University of Cambridge

Heterochronicity shapes brain network formation

Brain network formation unfolds on a nonuniform developmental timetable, with different cortical regions generating connections at different developmental phases. Generative network models (GNMs) aim to uncover the principles underpinning the organization of connectomes by creati...

Closed‐form solutions for dynamic punching shear assessment in flat slabs subjected to sudden column removal

Abstract Simplified closed‐form equations are commonly used in structural design to prevent punching shear failures of concrete flat slabs supported on columns in permanent and transient situations, whereas more advanced methods are generally used in verifications at accidental d...

Clinical and genetic risk factors for apolipoprotein L1-mediated chronic kidney disease in people of African ancestry with HIV

PURPOSE OF REVIEW: To summarize current understanding of the epidemiology, pathogenesis and management of HIV-Associated Nephropathy (HIVAN) and other forms of Apolipoprotein L1 (APOL1)-mediated chronic kidney disease (CKD) in people of African ancestry with HIV. RECENT FINDINGS:...

Surgical waiting times in patients with high‐ and low‐risk renal cell carcinoma in England

Objectives To assess to what extent hospitals meet the uniform English National Health Service ‘timely’ treatment standard, what happens after a breach, and determinants of delay for patients with high‐risk renal cell carcinoma (RCC). Patient and Methods Population‐based study us...

Bridging policy and implementation science: operationalising political and structural determinants for health policy implementation evaluation

Abstract Background Despite their critical role in shaping public health policy implementation, key political and structural determinants within implementation frameworks are often poorly defined, underreported, or treated as background rather than as core implementation variable...

Data-driven identification of small molecules inducing brown adipocyte activation and differentiation

Promoting the recruitment and function of human brown adipose tissue (BAT) holds significant promise for preventing and treating obesity and related metabolic complications. While identifying genes to enhance BAT recruitment and thermogenic activation is crucial, traditional upre...

Protocol for genome-wide differential methylation using long-read DNA sequencing in the cortex of a mouse model of Alzheimer’s disease

Third-generation sequencing enables direct detection of genome-wide 5-methylcytosine without bisulfite conversion. Here, we present a protocol for generating long-read DNA sequencing from mouse cortex and performing genome-wide differential methylation analysis. We describe steps...

Multivalued forbidden numbers of two-rowed configurations -- the missing cases

The present paper considers extremal combinatorics questions in the language of matrices. An $s$-matrix is a matrix with entries in $\{0,1,\ldots, s-1\}$. An $s$-matrix is simple if it has no repeated columns. A matrix $F$ is a configuration in a matrix $A$, denoted $F\prec A$, i...

There are different shades of green: heterogeneous environmental innovations and their effects on firm performance

While an established literature highlights the variety of firms' eco-innovation strategies, systematic evidence on the heterogeneous effects of different environmental innovations on different dimensions of firm performance is lacking. This study contributes to filling this resea...

A multiregional serosurvey of RNA virus-reactive antibodies in bats and rodents reveals the enzootic presence of flavi- and paramyxoviruses in African Pteropodidae

Bats and rodents have been identified as reservoir hosts of diverse RNA viruses that pose potential risks to humans. However, overall virus prevalence in wildlife and underlying factors determining the zoonotic potential of reservoir-borne viruses remain poorly characterized. Vir...

A Bayesian prevalence incidence cure model for estimating survival using electronic health records with incomplete baseline diagnoses

Retrospective cohorts can be extracted from electronic health records (EHRs) to study prevalence, time until disease or event occurrence, and cure proportion in real-world scenarios. However, EHRs are collected for patient care rather than research, and thus typically have comple...

In vivo DNA damage protection during cell migration across confining embryonic tissue environments

Abstract Cells migrating through confined spaces can experience nuclear deformation, nuclear envelope damage and DNA lesions, but the physiological consequences of confinement in vivo remain unclear. Using the zebrafish neural crest as a model of developmental migration, we show...

Reciprocal, reiterative pleasures in Jacques Rivette’s Céline et Julie vont en bateau

The year 2024 marked the fiftieth anniversary of Jacques Rivette’s Céline et Julie vont en bateau/Céline and Julie Go Boating (1974), a delightful odyssey about two women playing dress-up, roller-skating, eating bonbons and drifting in and out of a boudoir melodrama. The film’s m...

Noncentrosymmetric Manganese Bismuth Thiocyanate Perovskites

Abstract Symmetry-lowering orderings in perovskites can produce a wide range of functions. Thiocyanate based perovskites, AM(SCN)3, have orderings distinct from those of the atomic oxides, enabling new functional behavior. We report four new defect-ordered manganese thiocyanate p...

Ultrarobust, Rapidly Recoverable Superhydrophobic Coatings with Self-Similar Micro/Nanostructures and Reinforced Interface for Aluminum Alloy Protection

Abstract In the field of aluminum alloy protection, constructing durable superhydrophobic coatings through a simple strategy is always a great challenge. Here, we report a functional coating with high mechanical robustness and superhydrophobic recoverability, composed of 1H, 1H,...

The AML-Associated A338V Mutation Rewires GPR183 Signaling through C-Terminal Ensemble Redistribution

Abstract G protein–coupled receptors (GPCRs) rely on dynamic conformational ensembles to coordinate G protein activation and recruitment of regulatory transducers such as GPCR kinases and β-arrestins. The oxysterol receptor GPR183 has been implicated in hematological malignancies...

Antarctic sea ice over the past 130 000 years – Part 2: A review of its role in the Earth system

Abstract. Antarctic sea-ice cover reached historically low levels in 2023, consistent with the simulated decrease in sea-ice extent in response to anthropogenic warming. Antarctic sea ice is closely linked to multiple components of the Earth system, thus its demise could precipit...

Herpes simplex virus pUL56 abolishes neuronal activity by removing voltage-gated ion channels from the plasma membrane

Herpes simplex virus 1 (HSV-1) infections of the central nervous system cause encephalitis and are associated with increased risk of neurodegeneration, yet the molecular consequences of lytic infection in human neurons remain incompletely defined. We map the transcriptomic, prote...

Dynamics of human cardiogenesis and its disruption in trisomy 21

Abstract Developmental dynamics involve the specification of diverse cell types and their spatial organization into multicellular niches 1 . Here we combine single-cell and spatial multiomics to define 21 distinct tissue niches in the developing heart, which we use to develop a c...

Epigenetic insights into extreme longevity in the world’s oldest terrestrial animal, Jonathan

Aldabra giant tortoises ( Aldabrachelys gigantea ) are exceptionally long-lived. We sequenced the genome and methylome of Jonathan, a 194-year-old Aldabra, to explore the molecular basis of his longevity. Relative to other giant tortoises ( A. gigantea and Chelonoidis abingdonii...