University of Bristol

Challenges and opportunities for the construction of the next IntCal and SHCal radiocarbon calibration curves

Radiocarbon (14C) provides the most frequently used approach to dating the last 55 000 years. However, owing to fluctuations in past levels of 14C, all radiocarbon dating requires calibration to convert the 14C measurement obtained from a sample into a calendar age. This is achie...

Cefepime and Mortality

Importance Cefepime is recommended for the treatment of febrile neutropenia and gram-negative infections at moderate risk of ampicillin resistance locus C β-lactamase production. Concerns regarding cefepime’s safety have been raised in the literature without firm conclusions. Obj...

Approximate additivity in the solvent-mediated potential of mean force for ultrasoft particle systems

Recently, an approximate additivity principle has been successfully applied to molecular chemical potentials in ultrasoft particle systems [Hendrikse et al., Phys. Chem. Chem. Phys. 27, 1554 (2025)]. We articulate this additivity principle as one of two Ansätze and apply these to...

Building place-based capacity in an asymmetric system: supporting England’s devolution periphery or fuelling political spatial inequality?

In many national contexts, asymmetric decentralisation creates political spatial inequalities, as some places are given more power and resources than others. This can exacerbate underlying place-based disadvantages. Capacity-building programmes could offer an important counterwei...

Common variant contributions to neurodevelopmental risk in orofacial clefts

Abstract Background Children with cleft lip and/or palate (CL/P) experience increased rates of neurodevelopmental difficulties, including ADHD, autism spectrum disorder, and educational challenges. While rare neurodevelopmental copy number variants (ND-CNVs) are enriched in this...

Bio-interfacial engineering of electrophoretic coacervate microcapsules for cytocompatible on-skin displays

Electrophoretic ink (e-ink) holds significant potential for energy-efficient displays and sustainable alternatives to print media. However, their use in wearables is hindered by hazardous materials which are cytotoxic and sensitizing to human tissue. While commercial e-inks encap...

Robust, partially alive particle Metropolis-Hastings via The Frankenfilter

When a hidden Markov model permits the conditional likelihood of an observation given the hidden process to be zero, all particle simulations from one observation time to the next could produce zeros. If so, the filtering distribution cannot be estimated and the estimated paramet...

Parents' perspectives of schooling following the 2020-2022 Civil War in Tigray, Ethiopia: Insights from urban government schools

This study explores parents’ perspectives of schooling in Tigray, Ethiopia, in the aftermath of the Civil War (2020-2022). Hundreds of thousands of Tigrayan civilians died during the war, and educational infrastructure was devastated, with up to 90% of schools receiving varying l...

The Trade‐Off Between Sustainability Reporting Quality and Corporate Investment Activity: Does Political Stability Matter?

ABSTRACT This paper investigates the relationship between sustainability reporting quality (SRQ) and corporate investment activity, focusing on corporate investment intensity and corporate investment inefficiency, and the moderating role of national political stability. Using a m...

Silica Aerogel Microcompartments with On-Demand Reactivation Enable Mimicry of Natural Resurrection

Abstract Mimicking natural resurrection remains extraordinarily challenging. Herein, we report dormant aerogel-based synthetic microcompartments fabricated via a water-in-oil emulsion strategy to produce polyelectrolyte–surfactant complex membrane-coated mesoporous silica aerogel...

Working around rather than using it as intended: A think-aloud study of Differential Privacy library usability

Differential Privacy (DP) guarantees privacy-preserving data analysis, yet adoption remains limited. We conducted a think-aloud study with 22 Python developers of varied experience—they attempted two standard Differential Privacy analytics tasks across IBM DiffPrivLib, PyDP, and...

A qualitative exploration of further education college staff perspectives on the challenges and opportunities for using physical activity to support student mental health in England

Abstract Background The increasing prevalence of poor mental health amongst young people is a public health concern, and physical activity (PA) is a potential intervention that has both physical and mental health benefits. While education settings are important contexts for inter...

Impact of the HPV vaccination programme on anal HPV infection in gay, bisexual and other men who have sex with men: multi-site enhanced surveillance study in specialist sexual health services in England

ABSTRACT Background A national human papillomavirus (HPV) vaccination programme for gay, bisexual, and other men who have sex with men (GBMSM) in England began in 2016. We evaluated the impact of this programme by monitoring the prevalence of type-specific HPV infections over tim...

Young Autistic Children Spontaneously Take Others' Visual Perspectives

Spontaneous visual perspective-taking is fundamental to real-world social interactions but remains understudied in young autistic children, partly due to methodological limitations. The traditional dot-perspective task imposes substantial cognitive demands, limiting its suitabili...

NLTS Hamiltonians from Good Quantum Codes

Abstract. The no low-energy trivial state (NLTS) conjecture of Freedman and Hastings [ Quantum Inf. Comput., 14 (2014), pp. 144–180] posits that there exist families of Hamiltonians with all low energy states of nontrivial complexity (with complexity measured by the quantum circu...

Plotting the route from research engineering to policy: a Quarto geospatial analytics toolkit built with and for local government

Local authorities hold a wealth of geospatial transport data that has the power to provide critical insights intotransport networks in their constituencies. However, this data may not be research-ready or maximised to thefull due to constrained resources.Urban Ride Research is a...

PrEgabalin for Treatment Resistant generalised Anxiety disorder (PETRA): study protocol for a double-blind randomised controlled trial set in the UK

Generalised anxiety disorder (GAD) is common and increasingly recognised in primary care. Although antidepressants and psychological therapies are first-line treatments, many patients have residual anxiety and limited access to therapy. Evidence for effective next-step pharmacolo...

Current and Future Directions for Responsible Quantum Technologies: A ResQT Community Perspective

Abstract Quantum technologies (QT) are advancing rapidly, promising advancements across a wide spectrum of applications but also raising significant ethical, societal, and geopolitical impacts, including dual-use capabilities, varying levels of access, and impending quantum divid...

Exploring baryon semileptonic decays through polarization and entanglement

Abstract The unitarity of the Cabibbo–Kobayashi–Maskawa (CKM) matrix is a cornerstone of the standard model (SM). Precise tests of this unitarity require independent determinations of its elements, such as | V us |, which governs the transition between strange and up quarks. Curr...

The burden of suicide by paraquat poisoning in Taiwan (1987–2017): trends, geographic variations, and demographic characteristics

Pesticide self-poisoning accounts for 14%–20% of global suicides. Paraquat, a highly lethal pesticide, is involved in a considerable number of suicides in some countries. This study investigated the burden, trends, geographic variations, and demographic characteristics of pestici...