University of Bristol

Sea Level Emulator Intercomparison Project (SLEIP) Phase 1: Assessing emulated multi-century global mean sea level projections

Abstract. Simplified sea level modelling approaches calibrated against reference data, also referred to as sea level emulators, can explore future sea level rise and associated uncertainties with low computational cost. Here, we introduce the Sea Level Emulator Intercomparison Pr...

Pharmacological Targets for Periodontitis: A Systematic Review of Drug‐Target Mendelian Randomisation Studies

ABSTRACT Aim Drug‐target Mendelian randomisation (MR) studies investigate whether genetically proxied modulation of druggable proteins affects the risk of periodontitis, thereby identifying potential pharmacological targets. Methods A systematic review was conducted following PRI...

Robust inference and correlates from genetic associations with personality

Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustne...

Plasticity in collective behaviour helps fish shoals mitigate limited visual information from water turbidity

Group living can make animals more resilient or more susceptible to human-induced rapid environmental change. Freshwater and coastal habitats are becoming increasingly turbid because of human activity, which limits the availability of visual information and hence responses to cri...

Patient, surgeon, and institutional variation in dual-mobility component use in primary total hip arthroplasty

Aims The aim of this study was to quantify the contribution of patient-, surgeon-, and institution-level factors to variation in dual-mobility component use in primary total hip arthroplasty (DM-THA) in England. We sought to determine whether current patterns reflect appropriate...

Sleep as a window into thalamocortical pathology: generative modeling implicates NMDA receptor hypofunction in 22q11.2 deletion syndrome

Abstract 22q11.2 deletion syndrome (22q11.2DS) is a strong genetic risk factor for neuropsychiatric conditions, including schizophrenia, yet the underlying synaptic mechanisms remain unclear. Sleep EEG suggests thalamocortical dysfunction, but scalp data alone lack mechanistic re...

Oral health and systemic health outcomes: A call for interdisciplinary action

Abstract Objectives To make the case, from periodontology and dental public health, for interdisciplinary action on oral and systemic health, and to set out recommendations for practice, policy, education, and research. Materials and Methods A joint working group of the European...

Early definitive fracture fixation (EDFF) does not alter circulatory neutrophil activation status in physiologically restored polytrauma: a 72-h porcine observation study

Abstract Dysregulation of the cellular innate immune system, particularly involving leukocytes and mainly neutrophils, underlies post-traumatic inflammatory complications. Early definitive fracture fixation (EDFF) triggers immune activation and may exacerbate inflammatory complic...

Zeros of L-functions and large partial sums of Dirichlet coefficients

Abstract Let $$L(s,\pi )=\sum _{n=1}^{\infty }\lambda _{\pi }(n)n^{-s}$$ L ( s , π ) = ∑ n = 1 ∞ λ π ( n ) n - s be an L -function that satisfies a weak form of the generalized Ramanujan conjecture. We prove that large partial sums of $$\lambda _{\pi }(n)$$ λ π ( n ) strongly rep...

A critical (and) realist(ic) examination of psychology students’ perspectives on engaging with curriculum decolonisation initiatives

Higher education institutions globally are trying to decolonise their curricula, aiming to make them more inclusive and representative. Some departments are also seeking to redress the colonial structures engrained within higher education. Students are central to this work. Howev...

Exploring the psychosocial needs and nutritional status of older adults with alcohol use disorder: a mixed-methods study (The OLA Study)

Abstract Background Alcohol-related hospital admissions are rising in England, particularly among individuals aged 65 and over. While alcohol intake and nutritional status are important factors in health outcomes, they are often overlooked. Loneliness, also common in this age gro...

The outcomes of surrogate pregnancy using donor egg compared to surrogate’s egg: a systematic review

Abstract Purpose Surrogacy is either gestational (GS) using donor egg or traditional (TS) using surrogate’s own egg. GS is increasing, partly from assumptions over less difficulty in transferring the baby to intended parents. This systematic review investigates obstetric outcomes...

Purpose-built WAAM 316L benchmark walls for thermo-mechanical calibration and strain-based hardness prediction

Wire Arc Additive Manufacturing (WAAM) of 316L generates complex thermal cycles, distortion and work hardening that are difficult to validate in 3D. Hence, in this paper, we design, build and fully characterise two benchmark walls (two-layer and three-layer) expressly for calibra...

Polygenic score for sleep duration in relation to the risk of Alzheimer’s disease: results from the UK biobank

Abstract INTRODUCTION Studies have suggested sleep duration may be associated with Alzheimer’s disease risk, but findings based on self-reported sleep duration are likely to be influenced by reverse causation and residual confounding bias. METHODS A polygenic score (PGS) for devi...

Unpacking spatial dependence: a new experimental design for spatial autoregressive simulation

Abstract Simulating spatial patterns with varying levels of spatial autocorrelation is essential for evaluating models, estimators, and diagnostics. The spatial autoregressive (SAR) process is widely used for this purpose, but its main parameter affects both spatial autocorrelati...

9 Development of a Rapid Lateral Flow Assay for Early Identification of Glioblastoma and Brain Metastases Using a Circulating Serum Biomarker

Abstract Introduction Rapid diagnostic tools could improve the early detection of glioblastoma (GBM) and brain metastases (BM). Lateral flow assays (LFAs) offer a simple, point-of-care testing platform. Glial fibrillary acidic protein (GFAP) has previously been reported as a circ...

Implementation of health independent Domestic Violence Advisors (hIDVA): a qualitative study in five NHS Trusts

Abstract Background People who experience domestic abuse report increased use of healthcare services, compared to those not experiencing abuse. Independent Domestic Violence Advisors (IDVA) are evidence-based programmes that provide emotional and practical support to people exper...

Cumulative surgeon volume is associated with improved outcomes following hip arthroscopy: A national registry study

Abstract Purpose This study assessed the association between (1) annual and (2) cumulative surgeon volume and patient‐reported outcome measures (PROMS) after hip arthroscopic surgery for femoroacetabular impingement syndrome (FAIS) using data from the UK Nonarthroplasty hip regis...

The Mother Nature Programme: a single-arm mixed-methods feasibility study of a group nature-based intervention for mothers experiencing postnatal mental health difficulties and their infants

Abstract Background Postnatal mental health difficulties are common and often under-treated. Nature-based interventions have potential mental health benefits, but little research has focussed on their applicability postnatally. This study examined the acceptability and feasibilit...

Antidepressant Prescribing Trends for Adults With and Without Autism in the United Kingdom From 1997 to 2023: A Population‐Based Cohort Study Using Clinical Practice Research Datalink Aurum

Antidepressant prescribing and autism diagnoses have increased in recent years. We aimed to describe and compare trends in antidepressant prescribing, indications, doses and durations in autistic and non-autistic males and females in the United Kingdom (UK) from 1997 to 2023. Usi...