University of Bristol

Optimal exercise dose in adults with chronic low back pain disorders: systematic review with dose-response network meta-analysis

Objective To quantify exercise dose-response relationships and estimate the optimal dose in adults with chronic low back pain disorders (CLBDs). Design Systematic review with random-effects model-based (non-linear) dose-response network meta-analysis. Risk of bias was assessed wi...

Phenanthrene disrupts calcium transients and inhibits INCX in zebrafish ( Danio rerio ) ventricular myocytes

Phenanthrene is a polycyclic aromatic hydrocarbon (PAH) that is derived from fossil fuels and is present in most PAH mixtures found in water, air and soil. It has been shown to affect cardiac function of vertebrates, including fish. We investigated the effects of phenanthrene on...

Sport, exercise, and physical activity in children with cardiovascular disease. A Clinical Consensus Statement of the European Association of Preventive Cardiology (EAPC) of the ESC, the Association of Cardiovascular Nursing & Allied Professions (ACNAP) of the ESC, and the Association for European Paediatric and Congenital Cardiology (AEPC)

Regular physical activity offers numerous benefits to children's health and well-being and is essential for reducing cardiovascular risk in children with cardiovascular disease. Despite increasing evidence supporting its benefits, many young patients remain insufficiently active...

Knowledge explosions: the evolution of ideas in volcanology in Western Europe from 1750–1925 and impacts on current practice

In this paper we explore some of the ways in which ideas on and around volcanic activity developed from the mid-18 th to early-20 th Centuries in western Europe. We focus on arguments around concepts relating to the formation of volcanic mountains and processes of eruption, and d...

Examining the direction of association between attendance-related difficulties and maternal depression symptoms in two UK birth cohorts

Abstract Purpose Poor school attendance is a high priority for schools. Parental mental health is associated with school attendance problems, however, the direction of this relationship is unclear. This study examines the longitudinal direction of association between school atten...

PRISM with a Pinch of Salt: Simple, Efficient, and Strongly Unforgeable Signatures from Isogenies

Abstract The problem of computing an isogeny of large prime degree from a supersingular elliptic curve of unknown endomorphism ring is assumed to be hard both for classical as well as quantum computers. In this work, we first build a two-round identification protocol whose securi...

Induced seismicity at the Quest Carbon Capture and Storage project, Alberta

The 1st April and 9th May 2026 M L ≥ 4.0 earthquakes in central Alberta were felt across the city of Edmonton. The events were located near to Carbon Capture and Storage (CCS) operations at the Quest site. In this study we use an established induced seismicity assessment framewor...

ASEAN, Brunei Darussalam, and the Interplay of Foreign Policy and Public Opinion

Background Acknowledging that past studies on the Association of Southeast Asian Nations (ASEAN) have focused on elite and state-centric viewpoints, this study centers on people’s perspectives. The case of Brunei Darussalam, as one of the region’s smallest nations, reveals unique...

Genetically Predicted Circulating Lipid Traits and Risk of Primary Open-Angle Glaucoma: A Mendelian Randomization Study

Background: Observational studies examining the relationship between serum lipids and primary open-angle glaucoma (POAG) have yielded inconsistent findings, limiting causal inference. Mendelian randomization (MR) offers a robust approach to evaluate causality by leveraging geneti...

Children's Rights to the Best Possible Care: Establishing Processes for Data Collection in Routine Care to Address Questions of Intervention Effectiveness for Children With Speech Sound Disorder

PURPOSE: The United Nations Convention of the Rights of the Child (CRC) recognizes that all children have a right to the best possible care, CRC Article 24 (health, water, food, environment). For children with speech sound disorder, this is vital in order to protect their rights...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

Phosphorus limits the growth of bacterial and eukaryotic primary producers in recently deglaciated High Arctic soils

Glaciers are receding at unprecedented rates worldwide, exposing large areas of barren sediment that are quickly colonized by microbes. Nutrient availability is a critical driver of early ecosystem succession, but in the High Arctic its role has remained uncertain. This limits me...

Effect of diet on cognition, mental health and wellbeing among adolescents: a systematic review

A healthy diet is crucial for adolescents’ health and wellbeing. Current literature on dietary intake and its association with cognition, mental health and wellbeing has mainly focused on younger children. The aim of this systematic review was to explore the evidence for these as...

Referential Indeterminacy and De Re Thoughts

ABSTRACT Referential indeterminacy may seem to leave little room for de re or singular thoughts about ordinary objects. I argue that this impression is misleading. We can direct our thoughts at particular objects, even though there is no fact of the matter as to which objects are...

Ex-situ replication of concrete pore solution: alkali-activated concrete

This study presents a reliable methodology for simulating the evolving pore chemistry of alkali activated materials. Using ex situ leaching, binder alkali profiles were established, and concrete specimens were characterized over one year under air and water exposures via porosity...

Scalable Fitting Methods for Multivariate Gaussian Additive Models with Covariate-dependent Covariance Matrices

We propose efficient computational methods to fit multivariate Gaussian additive models, where the mean vector and the covariance matrix are allowed to vary with covariates, in an empirical Bayes framework. To guarantee the positive-definiteness of the covariance matrix, we model...

Antihypertensive Treatment and Risk of Metabolic Associated Fatty Liver Disease: A Drug-Target Mendelian Randomization

BACKGROUND: Metabolic dysfunction-associated fatty liver disease, conventionally known as nonalcoholic fatty liver disease (NAFLD), affects over a quarter of the global population and lacks approved pharmacological treatments. We investigated whether elevated blood pressure (BP)...

Assessing the Impact of Alkali Post-Deposition Treatment on the Surface Properties of High-Efficiency Kesterite Absorbers.

The performance of kesterite solar cells has steadily improved over the past five years, driven by advances in molecular precursor composition and processing. Inspired by their success in high-efficiency chalcopyrite devices, alkali-salt post-deposition treatments (PDTs) have bee...

Mental health problems as mediators between childhood trauma and cardiometabolic risk behaviours in the 2004 Pelotas Birth Cohort

BACKGROUND: Childhood trauma is associated with greater engagement in health risk behaviours (HRBs) that predispose to cardiometabolic disease. However, the mechanisms underlying these associations remain poorly understood. Mental health problems are hypothesised to mediate links...

The Role of Transparency in Repeated First-Price Auctions with Unknown Valuations

Abstract. We study the problem of regret minimization for a single bidder in a sequence of first-price auctions where the bidder discovers the item’s value only if the auction is won. Our main contribution is a complete characterization, up to logarithmic factors, of the minimax...