University of Bristol

Hydration Changes are Essential for Efficient Breakdown of Faropenem by the L1 Metallo-β-lactamase

Abstract Metallo-β-lactamases (MBLs) are key contributors to antimicrobial resistance (AMR). The L1 MBL, originally from Stenotrophomonas maltophilia, is a tetrameric, dizinc, subclass B3 MBL that efficiently hydrolyzes most β-lactam antibiotics and evades inhibitors that act on...

Parameter-efficient fine-tuning of SAM for SAR flood mapping: comparative performance and encoder–decoder representation analysis

Synthetic aperture radar (SAR) enables flood mapping under cloud and adverse weather, but segmentation remains challenging across heterogeneous environments. Deep-learning models can improve flood delineation, yet their dependence on task-specific training data limits transfer ac...

Viewpoint: the M-I-T-I framework for practice theory informed social marketing intervention

Purpose This viewpoint seeks to illuminate the utility of practice theory informed design in social marketing intervention development. It introduces the M-I-T-I framework (a four-stage approach comprising practice Mapping, insight Iteration, knowledge Transfer and co-created Int...

Chronotherapeutic considerations for antiplatelet therapy in cardiovascular risk prevention – A systematic review

Summary: Background: Cardiovascular physiology exhibits circadian rhythms, including a morning surge in platelet reactivity and cardiovascular events. Aligning the timing of antiplatelet therapy with these rhythms may be a simple, cost-effective approach to improve clinical effic...

Competing methods of divergence time estimation recover diverse evolutionary timescales

Abstract Molecular clocks convert evolutionary distances into geological times to infer time-scaled phylogenies. Methods differ in terms of fossil calibration strategy (node versus tip) and whether they use molecular and/or morphological data, but their relative performance remai...

Suppression of spectral gap and flat bands on a cuprate superconductor side-surface

Abstract Side surfaces of cuprate superconductors are expected to display a suppressed d -wave order parameter and zero-energy topological flat bands with a large density of states, making them susceptible to symmetry broken orders. Yet such surfaces have never been investigated...

The HEADSpAcE Data Center: An international data and biospecimen resource for head and neck cancer translational research

Head and neck cancer (HNC) comprises a heterogeneous group of malignancies with substantial variation in incidence, risk factors, and outcomes across populations. Existing studies are often limited by regional scope or lack integration of epidemiological, clinical, and molecular...

Where is the evidence? A global systematic review of sanitation system resilience to climate hazards

Despite sustained efforts over several decades, no region is projected to achieve universal sanitation access by 2030, according to international monitoring frameworks. Climate change is increasingly disrupting human and ecological systems, in turn deepening existing inequalities...

Find your village: a call for culturally coordinated understanding and action with migrant heritage families in the Global North

Refugees and forced migrants coming to the ‘Global North’ experience high rates of stress and isolation. Migrant communities are concerned about their young peoples’ long-term health, educational and social outcomes; there are reports of their children being referred at higher ra...

Greening cities to ensure biosphere functional integrity: Insights from Rotterdam and Lagos

The Earth Commission has proposed that 20-25% of every square kilometre of managed lands, including in cities, be reserved for nature to ensure its local functioning and human wellbeing -biosphere functional integrity boundary (BFI). This research adopted a multi-method justice-o...

Device-Measured Physical Activity, Sedentary Time, and Cardiometabolic Risk Markers in Youth

Importance The evidence for benefits of higher physical activity and lower sedentary time on the cardiometabolic risk profile in youth is based on cross-sectional and small prospective studies. Objective To determine the prospective associations between device-measured physical a...

Moving on Project: Explore the Transition to Adulthood With Young People With a Learning Disability Using Inclusive Research Methods

ABSTRACT Background For young people with a learning disability, transitioning to adulthood is a complex process, frequently resulting in limited choice and poor life outcomes. Existing research focuses on specific aspects of transitioning rather than young people's lives as a wh...

A diversified approach to the design of recombinant silk proteins for biomaterials

Silk offers a sustainable alternative to synthetic polymers, yet widespread industrial adoption has not been realised. Many current silk protein engineering efforts have focused on spider dragline silk; a pursuit made difficult by the metabolic burden of expressing high molecular...

Edge Multiway Cut and Node Multiway Cut are Hard for Planar Subcubic Graphs

Abstract It is known that the weighted version of Edge Multiway Cut (also known as Multiterminal Cut ) is -complete on planar graphs of maximum degree 3. In contrast, for the unweighted version, -completeness is only known for planar graphs of maximum degree 11. In fact, the comp...

An Inverse Design Workflow for Solvent Mixtures Based on Hansen Solubility Parameters

Abstract We present SolvPred, an open-source Python framework for inverse design of solvent mixtures based on Hansen solubility parameters (HSPs). SolvPred allows users to control the composition of solvent mixtures while setting essential experimental constraints. As a case stud...

Characterising the unequal supply of water in an intermittent water supply network in Lahan, Nepal

ABSTRACT Daily pressure traces used to calculate the median supply hours across the piped network. Intermittent water supply (IWS) affects over one billion people worldwide, resulting in unequal delivery of piped drinking water. Limited data from operational networks constrain ou...

Distinct roles for TANGO1S domains in maintaining ER-Golgi architecture

The endoplasmic reticulum (ER)-Golgi interface is a dynamic trafficking hub maintained in part by TANGO1, a scaffolding protein that coordinates proteins and membranes at ER exit sites (ERES). TANGO1 has two isoforms: TANGO1L, which has a lumenal SH3 domain, and TANGO1S, which la...

Content Moderation, the UK Online Safety Act, and the European Convention on Human Rights

The Online Safety Act 2023 (OSA) aims to protect citizens from online harms while also upholding freedom of expression. The task of this article is to confront the deep tension that those dual goals provoke through the lens of the European Convention on Human Rights (ECHR) by ask...

A flexible Monte Carlo quantitative bias analysis for unmeasured confounding

Quantitative bias analysis (QBA) for unmeasured confounding is essential for observational studies. A probabilistic QBA incorporates external information about the unmeasured confounders via prior distributions for certain parameters (known as bias parameters ) that specify the r...

Beyond-all-order asymptotics for homoclinic snaking of localised patterns in reaction-transport systems

Abstract Spatially localised stationary patterns of arbitrarily wide spatial extent emerge from subcritical Turing bifurcations in one-dimensional reaction-diffusion systems. They lie on characteristic bifurcation curves that oscillate around a Maxwell point as part of a homoclin...