University of Bristol

Early national comparison of robotic versus conventional hip replacements for arthritis using National Joint Registry data: target trial emulation study

Abstract Objectives To evaluate the early comparative effectiveness of robotic versus conventional total hip replacement (THR) in the UK. Design Target trial emulation study. Setting Public and private hospitals using data from the National Joint Registry of England, Wales, North...

Long-Distance Trade and Long-Term Persistence

Do changes in the location of trading opportunities cause changes in the location of economic activity? I explore this question using a lifting of restrictions on trade across the Spanish Empire in the eighteenth century. I combine a difference-in-differences approach with a dyna...

Investigating precipitation growth and decay due to orography using radar rainfall observations in Great Britain

Abstract This study investigates precipitation growth and decay (GD) characteristics across Great Britain (GB) using a five‐year (2007–2011) weather radar dataset. It aims to enhance radar‐based precipitation forecasting, which typically struggles with decreasing accuracy over le...

Beyond Pain: The Impact of Physical Pain on Conformity

ABSTRACT Physical pain is a pervasive feature of everyday life, yet little is known about how it shapes consumer decision‐making in socially influenced contexts, i.e., consumer decisions that are shaped, at least in part, by information about the preferences, judgments, or behavi...

Faculty Uses and Perspectives on Generative AI: Experiences From Two UK Veterinary Schools

Abstract The relatively recent emergence of generative AI (GenAI) tools and their potential to influence many aspects of faculty and student experiences requires rapid insight into these tools’ current uses, perceived challenges, and opportunities. A survey-based study was carrie...

Does ‘Moral Reframing’ Impact Support for Supervised Drug Consumption Facilities in the UK? An Experimental Vignette Study

The provision of supervised drug consumption facilities (SDCF) is a recent development in the United Kingdom (UK). The only currently operating facility opened in Glasgow in 2025. It has attracted extensive media and political scrutiny, often framed in moral terms. This experimen...

Nursing Vengeance in Euripides’ Medea and Dictys

This note shows how a newly-discovered papyrus containing a hypothesis of Euripides’ Dictys sheds light on an aspect of the tragic trilogy from which that play comes.

Identification of TMEM263 as an ER-resident protein that controls early stages of lipid droplet biogenesis

Abstract Cell and organismal growth is controlled not only by the availability of nutrients, but also the ability to dynamically sense and respond to changes in metabolic demand. We have identified a protein, TMEM263 (also known as C12orf23) as a mechanistic link between growth a...

Cross-platform, multi-cohort identification of a caries microbial signature

Objective To identify a robust salivary microbial signature associated with caries using a cross-platform, multi-cohort design.Design Full-length 16S rRNA gene sequencing (ONT) and shotgun metagenomics (MET) were performed in a derivation cohort with matched data (n = 463). Assoc...

Development and evaluation of a quality assessment tool for equality, diversity, and inclusion (QUALITY-EDI) within healthcare research

Implementing equality, diversity, and inclusion (EDI) in healthcare research is critical to ensuring findings are translatable and provide the greatest benefit to patients who need it most. A quality assessment scoring tool (QUALITY-EDI) was developed to evaluate the conduct of E...

Computing torsion for plane quartics without using height bounds

We describe an algorithm that provably computes the rational torsion subgroup of the Jacobian of a curve without relying on height bounds.Instead, the strategy is to find upper bounds for the torsion subgroup using reduction modulo primes and to search for torsion points, not jus...

Development of a complex intervention to optimise pre-operative healthcare and early recovery for people having knee or hip replacement: My Knee/Hip Plan

Abstract Background Approximately 250,000 total hip and knee replacements were performed in the UK in 2024. One in five patients who have a knee replacement and one in seven who have a hip replacement are dissatisfied with their outcome and/or have chronic pain after surgery. Som...

Conserved circadian membrane rhythms arise from divergent cellular mechanisms in pacemaker neurons of mice and Drosophila

Abstract Circadian clocks align physiology and behaviour with daily environmental cycles, requiring neuronal networks that encode and transmit time-of-day information. Whether conserved electrophysiological principles underlie circadian output across evolution remains unclear. We...

Dietary pattern and epigenetic aging: a longitudinal twin study

Diet is an environmental factor influencing aging and life expectancy. Age-associated DNA methylation and epigenetic clocks are primary hallmarks of aging and may be modified by diet. However, observed associations between diet and epigenetic clocks may be confounded by familial...

Data‐Driven Vertiport Site Selection: A Two‐Stage Framework With Multi‐Source Urban Data and Scalable Optimization

ABSTRACT Urban Air Mobility (UAM) is increasingly recognized as a promising solution to alleviate urban congestion and improve transportation efficiency, playing a key role in developing sustainable urban infrastructure. A central challenge for UAM deployment is the siting of ver...

Conjugate heat transfer and melting mechanisms of a metallic phase change capsule with an internal cavity under external forced convection

Conjugate heat transfer during charging of encapsulated metallic phase-change materials (PCMs) is controlled by external convection, shell conduction and transport within the melt. Previous studies commonly prescribe uniform shell temperatures or neglect the influence of internal...

Cooperatively breeding white-winged choughs use recruitment calls selectively in food-associated contexts

Many social animals produce vocalizations to attract others to food, with diverse benefits including improved foraging success, reduced predation risk and access to social and reproductive rewards. In some species, the production of such calls varies based on food divisibility, b...

Unwarranted variation in training in isolated coronary artery bypass grafting in the United Kingdom

OBJECTIVE: Several studies have reported comparable outcomes between trainees and consultants performing isolated coronary artery bypass grafting (CABG). However, the extent to which trainee operating opportunities vary between consultants and hospitals after accounting for patie...

Navigating dark kitchens in England: environmental health, planning, and public health perspectives

BACKGROUND: Dark kitchens, 'tech-enabled commercial kitchen(s) operating mostly for delivery, to fulfil remote on-demand consumer online orders of food for immediate consumption', are a global phenomenon. As part of a wider project exploring dark kitchens and the fast-moving onli...

Genetic risk factors for postoperative complications after major surgery and shared genetic aetiology with non-postoperative phenotypes

Abstract Background Up to 15% of patients worldwide experience serious postoperative complications after major surgery. We explored the genetic basis of five common postoperative complications and whether they share genetic aetiology with their non-postoperative equivalents. Meth...