University of Bristol

Biosynthesis and Genetic Tuning of Guanine Crystals via Metabolic Engineering of Yeast

ABSTRACT Purine crystals, such as guanine, generate diverse optical phenomena in animals and function as important nitrogen‐storage reservoirs in microalgae. Here, we demonstrate the formation of guanine crystals in Brewer's yeast. Whilst guanine crystals do not naturally contrib...

Optimal combination of composite likelihoods using approximate Bayesian computation with application to state-space models

Composite likelihood provides approximate inference when the full likelihood is intractable and sub-likelihood functions of marginal events can be evaluated relatively easily. It has been successfully applied for many complex models. However, its wider application is limited by t...

We Have Come to Be Destroyed: Growing Up in Cold War Britain

Asked to imagine her future life by the 1969 National Child Development Study, one 11-year-old girl described what she felt would be the difficulties of working motherhood: in the early morning she...

Patterns of practice and paediatric care

The question we raise in this paper is whether the notion of patterns of practice is useful in clinical ethics. The first part of the paper presents the notion of patterns of practice, describing what it reflects (including important themes from the philosophy of practice) and ho...

Bulldozing an immersed granular material in a confined channel

The motion of an immersed granular material in a channel is characterised by complex interactions among the grains, between the grains and the permeating liquid, and between the grains and the channel walls. Here, we develop a reduced-order continuum model for the bulldozing of a...

Teachers’ perceptions of physical activity in children and young people with type 1 diabetes: a qualitative systematic review protocol

Abstract Background Type 1 diabetes is a lifelong condition usually diagnosed in childhood. It requires daily management to control blood glucose and avoid complications. Physical activity brings important physical and emotional benefits, but children with the condition are often...

The importance of spatial structure in biology

Abstract Living things are highly complex and organised. This is often taken as an objection to reductionism and a point in favour of organicist views, which argue for the central role of the organism in all biological explanations. This paper argues that biological organisation...

Theoretical study into a novel design of oscillating water column with high broadbanded efficiency

This paper considers the theoretical operation of a novel wall-mounted oscillating water column wave energy device designed to be resonant over a broad range of frequencies. A curved duct with a submerged opening in a vertical wall is partitioned into a number of separate narrow...

Scalable Synthesisof a Masked Thiophenol as an Air-Stable,Odorless Intermediate to the Aurora Kinase Inhibitor Tozasertib (VX-680)

Abstract The use of thiophenols on process scales is fraught with challenges relating to their toxicity, malodor, and air sensitivity. We previously demonstrated that the Ni-catalyzed C–S coupling of aryl iodides and thiourea provides a discovery-scale route to S-aryl isothiouron...

Decoupling geometry and topography reveals contrasting ecomorphological signals in carnivoran carnassial teeth

Abstract The lower carnassial tooth (m1) is a key innovation underlying the ecological diversification of Carnivora. However, their exceptionally diverse phenotypes result from both functional adaptation and phylogenetic inertia which challenges ecomorphological inferences. We in...

Effects of maternal and paternal smoking on offspring cardiometabolic risk factors in adulthood: a multi-method intergenerational Mendelian randomization study

Abstract Background Parental smoking has been linked to several adverse offspring cardiometabolic outcomes; however, evidence is conflicting regarding the causal and long-term nature of these associations. Methods We investigated the effects of maternal and paternal smoking, capt...

William Johns, a Man Who Started as a Chemist and Druggist in London, Became a Baptist Missionary in India and Ended as a Medical Doctor in Manchester

William Johns (1787–1870) became a Baptist missionary in India in 1812 and eight months later was sent back to England on the order of the East India Company. His subsequent life involved working as a doctor for a short time in Birmingham, before returning to Calcutta under his o...

A clinical and experimental investigation of liraglutide effects on the brain-kidney axis

Glucagon-like peptide-1 receptor agonists elicit diuresis and natriuresis in humans and rodents. However, little is known about their interactions with the bodies hormonal systems that control fluid homeostasis. We performed a single center, open-label, before-and-after study and...

Greater Mediterranean Diet Adherence Is Associated with Lower Odds of Chronic Migraine: A Retrospective Observational Study

Background: Dietary factors may influence migraine burden, but the relationship between Mediterranean diet (MD) adherence and migraine chronicity remains unclear. This study aimed to investigate whether higher MD adherence is associated with a less severe migraine phenotype, part...

Iron-Catalyzed DealkenylativeBorylation of Alkenesvia Ozonolysis

Abstract Given the exceptional versatility of boronic esters as synthetic linchpins, strategies that directly transform naturally abundant motifs such as alkenes into boron-containing intermediates offer substantial value. Herein, we report the development of a dealkenylative bor...

Understanding possible differences between haemodialysis and haemodiafiltration which affect survival in end-stage kidney disease dialysis patients: the STITCHED study halted by the COVID-19 epidemic

<ns5:p>Background The mortality rate of kidney dialysis patients remains high, predominantly due to cardiovascular disease. The clearance of uraemic solutes with standard high-flux haemodialysis (HD) is mainly mediated by diffusion. More recently, haemodiafiltration (HDF), which...

Evaluating media equality in generative audiovisual composition using modality constraint and replay-based reveal

Abstract Coupled audiovisual instruments, in which sound and image are produced from a shared generative process, promise media equality by design. But does causal coupling actually deliver perceptual parity? This article asks how composers experience media equality and intermedi...

The Paradox of Political Consumerism: Neoliberal Natives and the Crisis of Political Imagination

Political consumerism is frequently celebrated as an expansion of youth political participation or critiqued for its structural ineffectiveness to advance young people’s political contestations. Moving beyond this evaluative binary, this article investigates its underexplored cul...

Periprosthetic joint infection

Infection is one of the most devastating complications following arthroplasty. The National Institute for Health and Care Research (NIHR) funded the multinational INFection ORthopaedic Management (INFORM) research programme to study this problem comprehensively, and then funded I...

Glucagon-like peptide-1 receptor agonists are associated with improved 90-day outcomes after total hip and knee arthroplasty

Aims Obesity and diabetes are risk factors for developing osteoarthritis and associated with worse outcomes following total hip (THA) and total knee arthroplasty (TKA). Glucagon-like peptide-1 receptor agonists (GLP-1as) improve glycaemic control and promote weight loss. The aim...