Universität Hamburg

Reconstruction-Free EIT for Injection-Pattern Classification and Superficial Gas Velocity Regression as Proxies for Local Gas Holdup in Bubble Columns

Abstract Electrical impedance tomography (EIT) as a noninvasive tomographic technique is increasingly applied to multiphase reactor monitoring; however, conventional image reconstruction is ill-posed and regularization-dependent and may be redundant in applications where the prim...

Barriers, challenges, and facilitators in oral health care for older adults in home-based care: stakeholder perspectives from germany

Abstract Background With the growing number of people requiring long-term care in Germany, not only is the prevalence of chronic diseases increasing, but oral health is also deteriorating. Many older adults with functional impairments who live at home can no longer maintain their...

Disease-activity-linked complement-coagulation interactions and persistent platelet activation in treatment-naïve systemic lupus erythematosus

Background Thrombosis is a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). Although multiple prothrombotic pathways have been identified, most have been studied individually or after treatment initiation. We aimed to characterize interactions between...

MooBench: A micro-benchmark for performance overhead measurement of observability tools

MooBench: A micro-benchmark for performance overhead measurement of observability tools EventType Research Software Publication Abstract Understanding the runtime behavior of software is inherently difficult due to the unpredictability of the software's behavior itself and the no...

Comparative Pharmacokinetics of Trientine Dihydrochloride Capsules: A Randomized, Open-Label, Reference-Controlled, Two-Period Crossover Study in Healthy Volunteers

Trientine dihydrochloride (TETA-2HCl) is an oral copper chelator used for Wilson disease. Because available formulations differ in marketed strength and may have formulation-specific pharmacokinetic properties, this study compared a 250 mg test capsule and a 300 mg reference caps...

Advanced Micromolding Approach toward Scaling-Up Smart Hydrogel Microvalves

Abstract Smart hydrogel valves are a promising technology for autonomous process control. At the macroscale, hydrogel valves offer high flow rates with slow response times, whereas hydrogel microvalves offer low flow rates with fast response times. This contradiction limits the p...

A general physiologically driven representation of leaf turnover in grasslands in the QUINCY land surface model (revision: 974a6b7f)

Abstract. Terrestrial vegetation plays an important role in shaping the Earth's climate due to its control on the global carbon cycle. Understanding and predicting vegetation phenology and biomass turnover into soil organic matter is therefore of great importance for our understa...

Multiple Bleaching of Hair: Fatigue Failure Investigations and Weibull Analyses

The fatigue failure (F/F) test is an important method for evaluating hair strength. In this study, we evaluate commercial European hair after up to four bleaches. F/F-data were directly fitted using a two-parameter cumulative Weibull distribution (CWD) function, described by life...

Noninvasive and objective near-real-time detection of pain changes during tonic fluctuating noxious heat stimulation

ABSTRACT: Chronic pain involves natural intensity fluctuations that patients cannot control, contributing to learned helplessness and functional impairment. Detecting spontaneous pain decreases could enable precisely timed interventions that enhance perceived control. However, ex...

Unilateral vitreoretinal proliferation and retinal vessel tortuosity in Proteus syndrome

Fig. 1 Full size image Multimodal retinal imaging of a 29-year-old woman of African descent with Proteus syndrome [ 1 , 2 ], showing tortuous retinal vessels with vitreoretinal proliferation along the superior vascular arcade in the left eye ( A , B ). The left half of the head w...

Invited perspectives: Towards usable compound event research

Abstract. Supporting stakeholders with science-based decision-making to mitigate and adapt to climate change impacts is a central mandate of the climate research community. In particular, mapping out scenario-dependent climate risk landscapes is one of the most pressing challenge...

Optimizing MRI sequence selection for glioma classification: a radiomics-based analysis of WHO CNS grade, final pathological diagnosis, and IDH status

Abstract Background Multi-sequence MRI protocols for glioma classification are resource-intensive, prompting the need to identify optimal, potentially reduced imaging protocols. Purpose To evaluate the diagnostic utility of individual MRI sequences (ASL, DWI, FLAIR, SWI, T1w, T2w...

Negotiating uncertainty and responsibility after a vestibular schwannoma diagnosis: a qualitative study of meaning-making and surgical decision-making

Abstract Background A diagnosis of vestibular schwannoma (VS) confronts patients with complex treatment decisions under conditions of uncertainty. While previous research has focused on treatment outcomes, symptom trajectories, and predictors of treatment choice, less is known ab...

COCaDA-web: an interactive web server for exploratory analysis of interatomic contacts in proteins

Protein contacts often serve as prerequisites for characterizing molecular interactions and bonds. Traditional implementations remain computationally expensive, posing significant scalability and usability challenges. We present COCaDA-web, an interactive and user-friendly Web Se...

Transforming Science with Large Language Models: A Survey on AI-assisted Scientific Discovery, Experimentation, Content Generation, and Evaluation

With the advent of large multimodal language models, science is now at a threshold of an AI-based technological transformation. An emerging ecosystem of models and tools aims to support researchers throughout the scientific lifecycle, including (1) searching for relevant literatu...

Morphology-Based Surgery for Chronic Pancreatitis Across Europe: Toward the Next Generation of Unified Guidelines

OBJECTIVE: To evaluate the use and impact of current surgical guidelines for chronic pancreatitis (CP) across Europe. SUMMARY BACKGROUND DATA: Current guidelines recommend morphology-based surgery for CP, but international studies evaluating their use and impact are lacking. METH...

Building a One Health mobile laboratory workforce: strengthening public health preparedness across Europe and Africa

Abstract The emergence and re-emergence of infectious diseases remain a major public health threat in Europe. The Horizon Europe-funded MOBILISE project addresses this challenge by establishing a One Health Mobile Laboratory capable of handling risk group 3 and 4 pathogens, while...

Mesenchymal stem cells as cellular factories for targeted P2X7 blockade after traumatic brain injury

Abstract Background Traumatic brain injury (TBI) causes long‐term disability, with inflammation contributing to both primary and secondary brain damage. Extracellular adenosine triphosphate (ATP) and its receptor purinergic receptor X7 (P2X7) drive neuroinflammation and represent...

Human cortical networks trade communication efficiency for computational reliability

Brains are often described as cost-efficient communication networks, optimally balancing the cost of long connections with the benefits of fast communication. Here, inspired by the "use it or lose it" principle, we present a novel game-theoretic model of self-organizing neural un...

Efficacy of dolutegravir or bictegravir-containing therapy in a real-life cohort of people with HIV-1 sub-subtype A6

OBJECTIVE: The objective of the study was to establish whether HIV-1 sub-subtype A6 (HIV-1A6) is a risk factor for virological failure in people with HIV (PWH) treated with the high genetic barrier integrase strand transfer inhibitors (INSTIs) dolutegravir (DTG) or bictegravir (B...