Universität Hamburg

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

Oxygen minimum zones in the Indian Ocean and their response to changes in the Indian Ocean meridional circulation

Abstract. The Oxygen Minimum Zones (OMZs) in the northern Indian Ocean (i.e., the Arabian Sea and the Bay of Bengal) are among the most intense OMZs in the world's oceans. While there has been no clear evidence of a significant change in the Bay of Bengal OMZ (BoB OMZ), the Arabi...

Critical impact of thermal management systems on on-board systems in hydrogen-powered aircraft

<title>Abstract</title> Hydrogen-powered aircraft offer a promising pathway to reduce the aviation sector's climate impact, with fuel cells providing high-efficiency power conversion at around 50%. However, producing considerable waste heat at around 80°C. Since this heat is gene...

Parent Mental Health From Preterm Birth Through the NICU Stay

OBJECTIVES: Preterm birth and neonatal intensive care unit (NICU) admission are not only extremely stressful for the infant itself but can also impact parental mental health. This Dutch national prospective cohort study aimed to describe the trajectory of parental mental health f...

Economic and behavioural policy coupling has divergent effects on electric vehicle adoption at individual and system scales

Abstract Policy mixes are key to accelerating low-carbon transitions. Yet, how combined policies impact electric vehicle (EV) adoption decisions and scale up to system-level diffusion remains unclear. Here we combine individual-level and system-level analyses to investigate how a...

Task-irrelevant stimuli robustly drive phasic pupil-linked arousal but only weakly affect memory formation

Abstract Brainstem arousal systems including the locus coeruleus noradrenaline system, respond transiently to behaviorally relevant events. This also drives dilations of the pupil, which are often observed during cognitive tasks. The strength of pupil responses during encoding of...

Comprehensive inter-comparison of generative AI models for super-resolution precipitation downscaling across hydroclimatic regimes

Abstract. High-resolution precipitation information is essential for hydrologic modeling, flood forecasting, and climate-risk assessment, yet global weather and climate models operate at spatial resolutions too coarse to resolve storm structure, intermittency, and extremes. Deep-...

Testing electron–photon exchange–correlation functional performance for many-electron systems under weak and strong light–matter coupling

We present results for a photon-free exchange–correlation functional within the local density approximation (pxcLDA) for quantum electrodynamics density functional theory (QEDFT), which efficiently describes the electron density of many-electron systems across weak to strong ligh...

Visual detection of flap tears on abrasive flap wheels using deep learning

Abstract During abrasive flap wheel grinding, flaps may fail and tear prematurely. Such flap tears increase local tool flexibility and can impair the uniformity of material removal in automated grinding processes. To ensure process reliability, this paper proposes a novel compute...

We don't care how much you sweat: An epistemic framework for behavioral and brain science laboratory infrastructure

For decades, behavioral and brain research has advanced by isolating single variables or brain regions to study behavior and performance. However, it has become increasingly clear that reductionist methods struggle to capture the complex, dynamic, and context-dependent nature of...

Challenges and opportunities of solar geoengineering for climate governance

Purpose This review characterizes the governance challenges arising from the potential deployment of solar geoengineering. The authors survey existing theoretical models that analyze the strategic incentives such technologies generate. In particular, this study examines the condi...

Extended service catalogue (NFDI4Earth Milestone MS3.1.3)

NFDI4Earth cooperates with re3data to ensure that repository information remains accurate, up to date, and comprehensive, as it is one of the primary sources of repository metadata for the NFDI4Earth Service Catalogue. This is an ongoing process, and, as in previous years, this w...

A Systematic Review and Meta-Analysis on 30-Day Readmission Rates After Endovascular Abdominal Aortic Aneurysm Repair and Open Repair

AIM: Endovascular aneurysm repair (EVAR) and open aneurysm repair (OAR) are established treatments for abdominal aortic aneurysm (AAA). This meta-analysis evaluated 30-day readmission, patient characteristics, postoperative complications, and length of stay after EVAR and OAR, an...

CMR-based aortic stiffness parameters in a symptomatic high risk obstructive sleep apnea cohort: results from the population-based Hamburg City Health Study

Abstract Background Aortic stiffness (AS) parameters as pulse wave velocity (PWV), aortic distensibility of the ascending and descending aorta (AD AoAsc, AD AoDesc) and pulse pressure (PP) are marker for vascular ageing, whereas data concerning obstructive sleep apnea (OSA) in po...

Crossing experiments suggest a simple genetic basis of complex male self-sacrifice phenotypes in widow spiders

Abstract Sexual cannibalism is among the most extreme outcomes of sexual conflict, and the Australian widow spider Latrodectus hasselti is well known for this behaviour. Curiously, males of L. hasselti actively facilitate cannibalism through self-sacrificial mating traits. During...

Technical note: reconstructing dose distributions from manually planned electron boosts in breast radiotherapy

Purpose In breast radiotherapy, delivery of manually-calculated electron boosts limits retrospective dose–response analyses as dose distribution is unavailable. This work evaluates the feasibility of reconstructing dose distributions from manually planned electron boosts in breas...

Complete left-tail asymptotic for branching processes with immigration

Abstract We derive a complete left-tail asymptotic series for the density of the martingale limit of a Galton–Watson process with immigration. We show that the series converges everywhere, not only for small arguments. This is the first complete result regarding the left tails of...

Female psychiatrists on screen: Cinematic stereotypes and therapeutic authority, 1935–2021

Throughout the 20th century, women entered psychiatry, yet cinematic representations remained structured by masculinised archetypes such as Dr Evil, Dr Wonderful, and Dr Dippy. This article interrogates depictions of female psychiatrists in nineteen films and one paradigmatic tel...

Evaluating clinical and neuroimaging predictors for cognitive-behavioral therapy outcome in obsessive-compulsive disorder

Abstract Cognitive-behavioral therapy (CBT) is the first-line treatment for obsessive-compulsive disorder (OCD), yet a significant number of patients do not achieve remission or substantial symptom relief. This study aims to enhance the prediction of CBT outcomes in OCD by integr...

On the Relationship between Polysemy and Type Frequency

Zipf and others in his wake examined the relationship between polysemy and token frequency but largely neglected the relationship between polysemy and type frequency. To redress this balance, an analysis was performed of seven samples from four languages, which can be classified...