Universität Hamburg

Suppression of meiotic double-strand break formation in somatic cells by DREAM factors TCX5/6 maintains genome stability

Meiotic recombination in reproductive cells is initiated by DNA double-strand breaks (DSBs) and requires the expression of meiosis-specific genes, yet how the transcription of those genes is regulated in either meiotic or somatic cells remains unclear. Here, using a representativ...

No justice for all! Green masculinity, extractivism, and global energy transitions

This article develops the concept of “green masculinity” as a socio-political order grounded in patriarchal structures that legitimizes car fetishism, large-scale technological control, extractive dominance, and violence against feminized bodies and territories as central strateg...

Challenges and pathways for renewable energy transition amid crisis: A case study on community perspectives during the Russian war against Ukraine

The ongoing war in Ukraine has exposed the vulnerability of centralised energy systems while increasing the importance of decentralised renewable energy for maintaining essential public services. Existing research has largely focused on infrastructure damage, national energy poli...

Culinary Chemistry as a Platform for Interfacial Materials Design

ABSTRACT This Review examines culinary systems as experimentally accessible models of interfacial materials design. Culinary operations, including emulsification, foaming, gelation, spherification, controlled heating, smoking, and dehydration, govern gas‐liquid, oil‐water, solid‐...

Diversity climate and experiences of discrimination in higher education: quantitative assessment of students’ perceptions

Purpose Demands for diversity recognition and equal opportunities are increasing in German higher education, accompanied by growing research interest in diversity climate and discrimination. Diversity climate refers to the collective perception of how diversity is acknowledged an...

Comparison of parental caregivers and associated factors with caregiver burden in rare paediatric diseases

Abstract Background Caregiving for children with rare diseases is associated with substantial psychosocial and practical burden, yet evidence on associated factors of caregiver burden across heterogeneous rare disease populations remains limited. Methods In this cross-sectional s...

Disease Duration Differentiates Freezing of Gait Response to Subthalamic and Nigral Stimulation for Parkinson's Disease in an Exploratory Multicenter Controlled Trial

BACKGROUND: Freezing of gait (FoG) belongs to most pressing unmet symptoms in the treatment of Parkinson's disease. OBJECTIVES: To explore whether combined subthalamic and nigral (STN + SNr) deep brain stimulation improves FoG compared with optimized STN stimulation alone; to ide...

Infinite Debt: The Happy Default: On the Day the Bill Went Unpaid, We Were Still Glad We Had Borrowed—and Somebody Lent Again

Version 1.0, 11 October 2026. Abstract Imagine a Tuesday in April 2087. A government announces that it will not repay its oldest bonds in full. Pensioners lose money, creditors take losses, and some citizens are furious. Yet the banks remain open, the infrastructure built with ea...

Longitudinal Functional Magnetic Resonance Imaging to Assess Lung Disease in Cystic Fibrosis

Abstract Rationale Matrix pencil decomposition magnetic resonance imaging (MP-MRI) enables quantitative assessment of lung ventilation and perfusion and was shown to correlate with contrast-enhanced (CE) perfusion MRI. Objectives To determine the longitudinal course of MP-MRI par...

A versatile Bacillus esterase reveals a carboxylesterase blueprint for PET intermediate degradation

Abstract The biodegradation of polyethylene terephthalate (PET), and its derived intermediate breakdown products, represents a core focus of multidisciplinary research. While Ideonella sakaiensis PETase (IsPETase) and leaf-compost cutinase (LCC) efficiently depolymerize PET, many...

A multiregional serosurvey of RNA virus-reactive antibodies in bats and rodents reveals the enzootic presence of flavi- and paramyxoviruses in African Pteropodidae

Bats and rodents have been identified as reservoir hosts of diverse RNA viruses that pose potential risks to humans. However, overall virus prevalence in wildlife and underlying factors determining the zoonotic potential of reservoir-borne viruses remain poorly characterized. Vir...

Exploring Family Interactions: Heterogeneity in Family Specific Network Models

ABSTRACT Daily family interactions have a profound impact on children's emotional and behavioral development. While extensive research highlights the detrimental effects of negative parenting practices and the benefits of positive parenting programs, less is known about the compl...

Indigenous environmental knowledge and flood resilience in Nigeria: a comparative study across ethnolinguistic communities

Purpose Indigenous Environmental Knowledge (IEK) remains central to disaster risk reduction in many African communities; however, its contribution to flood resilience, especially across different cultural groups, is under-examined in Nigeria. Previous Nigerian flood research has...

Automated Production of Gene-Edited CAR-T Cells for People Living with HIV

Adoptive transfer of gene-modified autologous T cells, for example, expressing chimeric antigen receptors (CARs), is a promising therapy option for a variety of malignant and nonmalignant diseases. Given their increased risk to develop certain cancer types, namely lymphoma, and t...

Cognitive impairment and danger to humanity, or personal assistant and learning tool? Exploring attitudes towards ChatGPT and their predictors

This study examines the factors shaping attitudes towards ChatGPT inclusive of personality traits, ideological orientations, AI literacy, gender, and cultural context. In Study 1 ( N total = 500; N valid = 472 Serbia), positive perceptions of ChatGPT as a learning tool and person...

Outcomes of front-line tagraxofusp in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN) in a real-world scenario

Abstract Tagraxofusp (TAG), a CD123-directed protein-drug conjugate, is approved in front-line and relapsed/refractory blastic plasmacytoid dendritic cell neoplasm (BPDCN). Multicenter real-world outcomes and the contribution of up-front consolidation post-TAG remain less defined...

Storm-modulated submesoscale dynamics over sloping topography in a wind-driven, non-tidal basin

While ocean surface submesoscales have been extensively studied, their counterparts in the bottom boundary layer (BBL) remain little explored. These subsurface features, however, appear to play a key role in (i) boundary-interior exchange, (ii) forward energy cascade, and (iii) t...

A cellular automata framework to study the diffusion in single and binary solvent systems

Abstract In this work, we present a two-dimensional cellular automata (CA) model to study mass transfer by diffusion of molecules in single and binary solvent systems. The method builds on Vanag’s probabilistic cellular automata (PCA), where diffusion is simulated through stochas...

GRETA: a results database for whole-genome sequencing studies

Whole-genome sequencing in large cohorts generates vast numbers of genetic association results, but integrating and querying them alongside public reference data remains a challenge for the diverse stakeholders involved. To address this challenge, we developed the Genetic REsults...

A Survey of Robotic Navigation and Manipulation with Physics Simulators in the Era of Embodied AI

Navigation and manipulation are core capabilities in Embodied AI, but training agents to perform them directly in the real world is costly, time-consuming, and unsafe. Therefore, sim-to-real transfer has emerged as a key approach, yet the sim-to-real gap persists. This survey exa...