Universität Hamburg

Precise predictions for trilinear Higgs couplings and Higgs pair production in extended scalar sectors with anyH3 and anyHH

Abstract A central objective of future collider experiments is to probe the structure of the Higgs potential, which requires access to trilinear scalar couplings, in particular the self-coupling of the observed Higgs boson. While this coupling is fixed in the Standard Model (SM),...

Structural dynamics during the three-ion Coulomb explosion of highly charged CS2 in intense soft x-ray pulses

Using intense femtosecond soft x-ray pulses above the sulfur 2p edge produced by the Free-electron LASer in Hamburg (FLASH), we investigate the multiple ionization and fragmentation dynamics of CS2. We focus on the three-ion fragmentation pathways of CS2 polycations with total ch...

Distinct lattice and charge excitations in AV3Sb5 kagome superconductors

The kagome superconductor family A V 3 Sb 5 ( A = Cs, Rb, K) provides a rich platform for exploring diverse electronic symmetry breaking phenomena, including superconductivity and various forms of density wave orders. Although these compounds share the identical lattice structure...

Brugada Syndrome in the Pediatric Population: Diagnostic Challenges and Clinical Outcome—Results of the German Multicenter Study COGIA

ABSTRACT Introduction Diagnosis and treatment of children and adolescents with suspected Brugada syndrome (BrS) is challenging. Aim of the study was to evaluate the applicability of current diagnostic criteria for pediatric patients with suspected BrS in the German multicenter st...

Tricuspid-Valve Intervention in Heart Failure

BackgroundThe effect of transcatheter tricuspid-valve repair on clinical outcomes, including death and hospitalization for heart failure, in patients with severe tricuspid regurgitation remains uncertain. MethodsWe randomly assigned patients with symptomatic severe tricuspid regu...

Cool Citizens? How Affectively Unpolarized Citizens View and Participate in Democracy

Abstract Does affective polarization change how citizens view and participate in democracy? We posit that the answer to this crucial question depends on how affectively un polarized citizens view and participate in democracy. Yet, the most common operationalization of affective p...

Robotic-assisted compartmental dissection for retroperitoneal sarcoma: a feasibility study on cadavers with the da Vinci Xi system

Abstract Purpose Retroperitoneal sarcomas (RPS) pose major technical challenges because of their size, anatomical complexity, and need for multivisceral resection. We evaluated the feasibility of a standardized robotic approach for right- and left-sided retroperitoneal sarcoma (R...

The Molecular Architecture of Somatic Spines of the Lateral Septum

ABSTRACT The lateral septum is a key subcortical structure and has been implicated in social memory. One aspect of social memory, the ability to recognize relatives, is conserved across vertebrate species and reflected in stable, lifelong memories. Synapses are considered to be t...

Metacognitive Training for Negative Symptoms (MCT-Minus) in schizophrenia: study protocol for a pragmatic randomized controlled trial

Abstract Background Negative symptoms are experienced by up to 60% of the individuals with schizophrenia and represent a stronger indicator of current and future functioning than positive symptoms. These symptoms respond poorly to pharmacological and existing psychosocial interve...

Prediction of Treatment Benefit With Internet-Based Cognitive Behavioral Therapy for Depression

Importance Treatment benefit prediction models may help identify which patients will benefit most from internet-based cognitive behavioral therapy (iCBT) for depression; it is unclear whether such models can support useful treatment allocation across programs. Objective To develo...

Pediatric intensive care follow-up in Germany is rarely established and highly heterogeneous: a nationwide survey of 20 PICUs

BACKGROUND: Survival after pediatric critical illness has improved substantially, but many survivors and their families experience long-term physical, neurocognitive, psychological and social sequelae, summarized as post-intensive care syndrome in pediatrics and in families. Stru...

Topology optimization considering contact and stress constraints

Abstract This work advances the field of stress-constrained topology optimization by addressing frictionless unilateral contact problems. The approach focuses on minimizing mass of a contact-constrained structure while enforcing stress-constraints using local or global stress mea...

Learning curve and target-based accuracy of diode laser versus scalpel incisions in a porcine skin model: a preclinical feasibility study with undergraduate dental students

PURPOSE: Despite the growing clinical application of diode lasers in oral surgery, laser training remains underrepresented in dental curricula. This study evaluated the feasibility of structured preclinical diode-laser training and characterized the early learning curve of underg...

Moiré‐Induced Symmetry Breaking of Charge Order in van der Waals Heterostructures

ABSTRACT Layered materials that stack different lattice symmetries are rare in nature. Misfit layered chalcogenides, which combine square and hexagonal lattices of rocksalt monochalcogenides and transition‐metal dichalcogenides, provide a platform to explore how incommensurabilit...

Robot in a crib: How a playing robot helps us understand sensorimotor contingency learning

Learning sensorimotor contingencies—that is, the link between one’s actions and their sensory effects—is fundamental to developing body knowledge, understanding causality, and developing a sense of agency. In developmental psychology, this process is classically studied using the...

State-dependent binding of the wedge domain controls inactivation of the mechanosensitive ion channel PIEZO1

Abstract The mechanically activated ion channel PIEZO1 transduces membrane tension into intracellular calcium signals and is critical for a wide range of physiological processes. Recent structural and functional studies have established a detailed framework for PIEZO1 activation,...

Effectiveness of an interactive music tablet intervention to reduce procedural anxiety in children: a randomized controlled trial

Abstract Procedural anxiety in children is common and associated with maladaptive behavior, reduced cooperation, and increased perioperative stress. Although music-based interventions show promise, few are designed for routine clinical care. We evaluated an interactive tablet-bas...

Daratumumab, lenalidomide, and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: MAIA final survival analysis

Abstract In previous analyses of MAIA, daratumumab plus lenalidomide/dexamethasone (D-Rd) significantly improved progression-free survival and overall survival (OS) versus lenalidomide/dexamethasone (Rd) in transplant-ineligible newly diagnosed multiple myeloma (NDMM). We report...

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

Oxygen minimum zones in the Indian Ocean and their response to changes in the Indian Ocean meridional circulation

Abstract. The Oxygen Minimum Zones (OMZs) in the northern Indian Ocean (i.e., the Arabian Sea and the Bay of Bengal) are among the most intense OMZs in the world's oceans. While there has been no clear evidence of a significant change in the Bay of Bengal OMZ (BoB OMZ), the Arabi...