Universität Hamburg

Gut resilience and clinical homeostasis following administration of neomycin and albendazole in soil-transmitted helminth-infected adults living in Lambaréné, Gabon

Abstract Purpose Gut resilience and systemic homeostasis are interrelated dynamic functions. A gut that fails to regulate intestinal barrier integrity, metabolite production, and immune regulation will lead to systemic pathogenic invasion and susceptibility to infections. Gut res...

A Survey of Robotic Navigation and Manipulation with Physics Simulators in the Era of Embodied AI

Navigation and manipulation are core capabilities in Embodied AI, but training agents to perform them directly in the real world is costly, time-consuming, and unsafe. Therefore, sim-to-real transfer has emerged as a key approach, yet the sim-to-real gap persists. This survey exa...

Quantifying aggregation bias in marsh carbon flux estimates caused by rhizosphere oxygen heterogeneity

Oxygen (O 2 ) in marsh rhizospheres varies strongly at millimetre scales due to radial oxygen loss (ROL), re-oxidation of reduced compounds, hydrology, and sediment structure. Yet many models estimate heterotrophic (microbial) respiration at a single mean O 2 , which can bias CO...

A scene-mapped framework for deriving clear-sky surface longwave downward radiation from remotely sensed measurements

Accurate estimation of clear-sky surface longwave downward radiation (LWDR) is fundamental to surface energy budget studies, yet widely used parameterizations and conventional lookup-table (LUT) searches often suffer from regional biases and limited transferability. This study de...

Radiation damage in serial femtosecond crystallography studied in hemoglobin.

) and fixed photon energy (7.15 keV). Structural refinement produced very similar models and resolution-dependent data-quality indicators remained comparable. Both datasets also retained sufficient anomalous signal for phasing. These observations support the conclusion that high-...

Nucleosynthesis in the fast ejecta of a neutron star merger

Abstract Neutron star mergers are today considered a major production site for rapid neutron capture elements. While the bulk of the matter escapes at fast, but non-relativistic velocities (~0.2 c), a small amount of the dynamically ejected mass reaches mildly relativistic veloci...

High‐Order Projection‐Based Upwind Method for Simulation of Transitional Turbulent Flows

ABSTRACT We present a scalable, high‐order implicit large‐eddy simulation (ILES) approach for incompressible transitional flows. This method employs the mass‐conserving mixed stress (MCS) method for discretizing the Navier‐Stokes equations. The MCS method's low dissipation charac...

Tinnitus in urban settings: insights into lifestyle and medical factors from the Hamburg City Health Study

PURPOSE: Tinnitus is a common and multifactorial auditory condition associated with considerable psychosocial burden. Evidence regarding its relationship with demographic, lifestyle, and medical factors remains inconsistent. This study aimed to determine the prevalence and correl...

3D Nanoprinted Structures Promote Robust Integration of Brain Organoids into Topography‐Guided Neuronal Networks

ABSTRACT Two‐photon polymerization‐based 3D nanoprinting (3DN) is a potent tool for the fabrication of highly specialized cultivation platforms that enable guided neuronal networks. However, despite the design freedom offered by 3DN, specialized cultivation platforms that activel...

Demulsification kinetics of water-in-oil crude oil emulsions using peracetic-oxidized rice husk lignin

Crude oil water-in-oil (W/O) emulsions present persistent operational challenges during petroleum production and processing because of their resistance to droplet coalescence and phase separation. Although lignin-derived materials have emerged as promising sustainable demulsifier...

A comparative study of causal machine learning models for personalized treatment of acute ischemic stroke

Abstract Background Accurate estimation of the individualized treatment effect (ITE) is critical for supporting personalized decision-making in acute ischaemic stroke, while the average treatment effect (ATE) provides a cohort-level benchmark for method comparison and context. Ho...

Rheumatologists’ expectations and perceptions of T-cell redirecting therapies: results from a cross-sectional survey

Abstract T-cell redirecting therapies (TCRTs), including Chimeric antigen receptor (CAR)-T cells and T-cell engagers (TCEs), are emerging as transformative treatments for autoimmune diseases. However, clinical application is currently restricted to specialized centers, leaving mo...

Insights into the survival impact of delayed immunochemotherapy in newly diagnosed diffuse large B-cell lymphoma: results from a nationwide registry study

BACKGROUND: The prognostic impact of the diagnosis-to-treatment interval (DTI) in diffuse large B-cell lymphoma (DLBCL) remains controversial. We investigated the association between DTI and three-year all-cause mortality in a nationwide cohort. METHODS: We conducted a retrospect...

Clathrin adaptors drive phase separation in endocytosis and trafficking

Abstract Liquid–liquid phase separation (LLPS) underlies the formation of biomolecular condensates that organize processes, including endocytosis and membrane trafficking. Although LLPS has been implicated in clathrin-mediated pathways, the contribution of adaptor proteins to con...

AllShowers: One model for all calorimeter showers

Accurate and efficient detector simulation is essential for modern collider experiments. To reduce the high computational cost, various fast machine learning surrogate models have been proposed. Traditional surrogate models for calorimeter shower modeling train separate networks...

Mandatory sustainability reporting and corporate hiring: the impact of CSRD introduction in Germany

Abstract Adopting an institutional theory perspective, I study the impact of the introduction of mandatory sustainability disclosure regulation on corporate hiring efforts for new sustainability reporting personnel. Using a difference-in-differences (DID) methodology, I analyse t...

Variability of internal snow properties over Antarctic late summer sea ice on different spatial scales

Snow on Antarctic sea ice strongly affects thermodynamic processes, sea ice mass balance, and microwave remote sensing, yet its spatial variability and characteristic length scales remain poorly quantified. The aim of this study is to provide a spatially extensive, layer-resolved...

Microfoundations of Dynamic Capabilities for Eco‐Innovation in SMEs: Evidence From Industrial Case Studies

ABSTRACT This study examines the microfoundations, that is, skills, processes, structures and decision rules that underlie the dynamic capabilities enabling SMEs to achieve sustained eco‐innovation performance. Building on dynamic capabilities framework, we adapt it to the SME co...

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...

Pain characteristics in isolated cervical dystonia: comparison to orthopedic cervical conditions and assessment of botulinum toxin effects

Abstract The objective was to characterize pain and evaluate quality of life (QoL) in cervical dystonia (CD) by comparing pain profiles with patients affected by orthopedic cervical conditions (OCC) and evaluating differences between CD patients with and without head tremor (HT)....