Universität Hamburg

Integrated longitudinal analysis of ctDNA, radiologic response, and tumor volume reveals spatial and temporal heterogeneity in advanced melanoma

Abstract Background In advanced melanoma, longitudinal disease monitoring remains limited by infrequent biomarker assessment and predominantly categorical imaging readouts. Although circulating tumor DNA (ctDNA) correlates with tumor burden, its behavior under high-frequency samp...

In-Context Molecular Property Prediction with LLMs: A Blinding Study on Memorization and Knowledge Conflicts

Abstract The capabilities of large language models (LLMs) have expanded beyond natural language processing to scientific prediction tasks, including molecular property prediction. However, their effectiveness in in-context learning remains ambiguous, particularly given the potent...

Effectiveness of concept map–based reflective learning for teaching peripheral intravenous catheterization to first-year nursing students: a cluster-randomized controlled trial

Traditional teaching methods in nursing education may not effectively integrate theory and practice. Concept map–based reflective learning may facilitate knowledge organization and support meaningful learning and critical thinking. This cluster-randomized controlled pretest–postt...

Robots and Jobs Revisited: A Bit-Exact Replication, Shift-Share Anatomy, and Capital-Stock Extension of Acemoglu and Restrepo (2020)

Version 1.01, 16 September 2026. This paper revisits the robot-exposure design of Acemoglu and Restrepo (2020). The first contribution is a bit-exact replication of a deliberately narrow benchmark: Table 7, columns 3 and 6. Starting from the underlying data sources, I reconstruct...

Efficacy, safety and circulating tumor cell dynamics in patients treated with Eribulin for HER2-negative advanced breast cancer – results from the phase II DETECT IVb trial

Abstract Background Eribulin is a non-taxane microtubule inhibitor that showed survival benefits for pretreated metastatic breast cancer (MBC) patients. Circulating tumor cells (CTCs) are a prognostic marker, but their role in predicting response to specific MBC treatments is les...

Impedance-based tracking of a cochlear implant electrode reliably detects successful array insertion

Abstract Introduction Continuous impedance measurements during cochlear implantation have been hypothesized to provide a reliable indication if the electrode is inside or outside the cochlea. Therefore they provide a valuable feedback mechanism for successful insertion to the sur...

Bridging the gap between genomic, phenotypic, and modeling data in picophytoplankton–virus interactions

Abstract We present a comprehensive synthesis of recent developments in methodological approaches to combine experimental and genomic studies of picophytoplankton–virus interactions. This synthesis will not only enhance our understanding of these relationships but also stimulate...

Problematic social media use among young people in Germany: frequency and associated psychosocial and behavioral factors – results from the COPSY study

Abstract Problematic social media use (PSMU) among young people has become an increasing public health concern. This study examined the frequency of at-risk and pathological social media use and factors associated with PSMU using data from T1 (wave 7; 2024) and T2 (wave 8; 2025)...

Belantamab mafodotin plus venetoclax in t(11;14)-positive relapsed or refractory multiple myeloma – the BELI(E)VE trial

Abstract Background Multiple myeloma (MM) is a widely incurable B-cell malignancy that predominantly affects older adults, representing 10% of hematologic cancers. Despite advancements in therapy that have significantly extended median overall survival (OS), MM remains a clinical...

Biomineralization-Assisted Valorization of Phosphogypsum

Abstract The sustainable management of phosphogypsum (PG), a solid waste generated during phosphate fertilizer production via the wet-process phosphoric acid route, remains a major environmental and resource challenge. Transforming this waste stream into functional resources is a...

“I’m talking about here and now”: self-reflexivity, history, and climate futures in contemporary lecture plays

Abstract Sabrina Mahfouz’s A History of Water in the Middle East begins with a self-reflexive passage that establishes the play’s peculiar form, a lecture. Her choice of aesthetic frame and discussion of climate change resonate with an earlier such lecture play at the Royal Court...

Comparing different pathways to primary mathematics teaching using teacher competence measurement of the TEDS research program

Abstract Teacher shortages are a major challenge worldwide, especially in mathematics. In response, many countries have implemented measures to recruit graduates from fields other than mathematics teaching for alternative pathways into the teaching profession, offering an alterna...

Biliary complications in pediatric living donor liver transplantation: An international multicenter analysis of risk and prognostic factors

Biliary reconstruction is often considered the Achilles’ heel of liver transplantation, yet risk factors and outcomes remain poorly defined, particularly in pediatric living donor liver transplantation (LDLT). This international multicenter study aims to identify predictors of bi...

Study of Supernova Neutrinos at ESSnuSB

In this paper, we have studied the sensitivity of the ESSnuSB far detector to supernova neutrinos. ESSnuSB is a proposed long-baseline neutrino experiment in Sweden, which will use a 538 kt water Cherenkov detector to probe the leptonic phase δCP by studying the second oscillatio...

Pluralising the economic knowledge of politics. Evidence from a German case study

Economic expertise in German policymaking has long been shaped by technocratic, market-liberal advisory bodies closely connected to mainstream economics. Over the past decade, however, an alternative knowledge ecosystem - the New Economy Space (NES) - has emerged, promoting heter...

Clinical usability of an explainable AI decision support tool and evaluation of multimodal models in NSCLC

Abstract Despite a decade in, immunotherapy (IO) treatment selection in non-small cell lung cancer (NSCLC) remains largely guided by subgroup analyses and imperfect programmed death ligand 1 (PD-L1) and clinical scores. To our knowledge, I 3 LUNG ( NCT05537922 ) is currently the...

Parvovirus B19 infections in paediatric sickle cell disease patients: Genotype and hydroxyurea treatment influence disease severity

Summary In patients with sickle cell disease (SCD), parvovirus B19 infection (B19V) leads to acute anaemia (aplastic crisis), but may also be associated with other serious complications. We retrospectively analysed clinical data from paediatric SCD patients with B19V infections b...

Multiple Argonaute complexes orchestrate epigenetic silencing in the Arabidopsis germline

Abstract Small RNAs (sRNAs) are widespread across diverse flowering plant species and play important roles regulating reproduction and environmental responses. However, how sRNAs exert their function is largely unknown, likely due to their typical origin in non-genic regions, the...

Methods for analyzing recurrent and terminal events considering composite and competing endpoints in clinical trials: a practical overview

Abstract Time to event endpoints like time to myocardial infarction, relapse, or death are often of primary interest in clinical trials. To describe the whole disease process and gain a complete picture of treatment effects, methods for recurrent time to event analysis considerin...

On the archaeological evidence of mansiones along the Roman roads of Hispania in the Antonine Itinerary: The case of Mellaria (Fuente Obejuna, Córdoba, Spain)

The functioning of the cursus publicus in Roman Hispania relied on a regular network of roadside stations ( mansiones ), whose archaeological identification remains a challenge due to the scarcity of visible surface remains. This article presents the discovery of a previously und...