Universität Hamburg

Soil redox potential and plant species identity likely affect root-associated fungi in salt marshes

Abstract Root-associated fungi (RAF) are important for plant performance because they form beneficial, neutral, or pathogenic relationships with their hosts, thus regulating nutrient uptake, stress tolerance, and overall plant fitness. At the transition from marine to terrestrial...

Prophylactic vs Therapeutic Anticoagulation in Hospitalized Patients With COVID-19

Importance Coagulopathy in the context of COVID-19 is a major threat due to deep vein thromboses and pulmonary embolisms. Objective To assess whether therapeutic anticoagulation on top of standard of care (SOC) compared with prophylactic anticoagulation as part of SOC can improve...

Family-centred psycho-oncological counselling for parents with cancer: a longitudinal secondary data analysis of psychological distress, family functioning and parental concerns

BACKGROUND: When a parent is diagnosed with cancer, it can place a significant burden on the entire family. The aim of this study is therefore to analyse the psychological distress experienced over time among cancer patients or their partners who are raising minor children and wh...

What Is the Observed Sensitivity of Arctic Sea Ice?

Abstract The observed sensitivity of the Arctic summer sea‐ice area (SIA) to changes in the external forcing is a key quantity for understanding and projecting sea‐ice loss. Here, we estimate this sensitivity and provide a robust analysis of its uncertainty considering the impact...

Diagnostic concordance of remote WSI-based thyroid cytology compared to conventional cytological diagnosis: a pilot study

Abstract Background Whole slide imaging (WSI) has emerged as a key component of digital pathology, enabling remote diagnostics and standardized evaluation. However, its diagnostic concordance in thyroid cytopathology, particularly under real-world conditions, remains insufficient...

Immune Interactions Unique to Intradermal Microtoxin: Insights From Aesthetic, Therapeutic, and Vaccination Studies

ABSTRACT Introduction Intradermal botulinum toxin type A (BoNT‐A; microtoxin) has been shown to improve skin texture, superficial rhytides, and sweat/sebaceous activity through neuronal (cholinergic) and non‐neuronal pathways. While discussions around immune system interactions f...

A multi-site loiasis dataset of whole blood videos

Loiasis is a blood-borne filarial infection under consideration for inclusion in the WHO’s priority list of Neglected Tropical Diseases. In addition to its direct impact on human health, loiasis frequently occurs as a co-infection with other filarial diseases, including onchocerc...

Construction and characterisation of the DarkSide-20k veto silicon photo-multiplier tiles

Abstract Silicon photo-multipliers (SiPMs) are state-of-the-art sensors capable of detecting a single photoelectron under cryogenic conditions, with potentially lower radioactivity than widely used photomultiplier tubes. The DarkSide-20k experiment, designed to perform direct dar...

Innovation dynamics across institutional environments: regulatory exposure and geopolitical shocks in nanotechnology

Nanotechnology represents a general-purpose technology with significant transformative potential across industrial sectors. Its commercialization, however, unfolds within regulatory systems that differ across application domains and countries, making institutional exposure a stra...

Psychotherapy remission prediction models show limited cross-clinic generalizability in routine outpatient care

Abstract Clinical prediction models for psychotherapy outcomes have the potential to assist therapists in planning a patient’s individual treatment, but their clinical utility depends on maintaining predictive performance across settings. We assessed prediction of post-treatment...

Summary of Research: HER2CLIMB-05: A Phase III Study of Tucatinib Versus Placebo in Combination with Trastuzumab and Pertuzumab as First-Line Maintenance Therapy for HER2+ Metastatic Breast Cancer

This is a summary of a research article reporting the findings of the HER2CLIMB-05 trial (NCT05132582), a randomized, double-blind, placebo-controlled, international, phase III trial. The HER2CLIMB-05 trial was conducted to compare the efficacy and safety of adding tucatinib vers...

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF ‐Tu for AMPylation

Fic enzymes mediate diverse post-translational modifications, including adenosine monophosphate (AMP) transfer and removal, referred to as AMPylation and deAMPylation, respectively. We identified the prokaryotic translation elongation factor Tu (EF-Tu) as an AMPylation target of...

Neural responses during natural vision are action-timed rather than locked to the onset of stable foveal input

Visual processing is traditionally studied using static viewing paradigms in which researchers analyse brain responses to the onsets of a sequence of randomly selected stimuli. Translating this “stimulus onset” approach to active vision paradigms that allow for free eye-movements...

A systematic review of ultrasound to predict severe disease in patients with dengue and other viral infections associated with hemorrhagic fevers

Background Viral infections associated with hemorrhagic fevers (VaHFs) cause millions of cases each year across a broad geography with severity ranging from asymptomatic cases to clinical disease with a high case fatality rate. Commonalities in pathophysiology across VaHFs includ...

In-Context Molecular Property Prediction with LLMs: A Blinding Study on Memorization and Knowledge Conflicts

Abstract The capabilities of large language models (LLMs) have expanded beyond natural language processing to scientific prediction tasks, including molecular property prediction. However, their effectiveness in in-context learning remains ambiguous, particularly given the potent...

Incidence and Predictors of Braid Deformations following Aneurysm Treatment with the DERIVO(2heal) Flow Diverter: A Single-Center Experience

BACKGROUND AND PURPOSE: Flow diverters (FDs) are established endoluminal devices for intracranial aneurysm treatment. Concerns have been raised regarding braid deformations (BDs) affecting braid stability. We investigated the incidence and potential predictors of BDs in DERIVO an...

Max Weight Independent Set in sparse graphs with no long claws

For graphs \(G\) and \(H\) , we say that \(G\) is \(H\) -free if it does not contain \(H\) as an induced subgraph. Already in the early 1980s Alekseev observed that the Max Weight Independent Set problem ( MWIS ) remains NP -hard in \(H\) -free graphs, unless every component of \...

Storage treatment and diluent cause inconsistencies in commonly used fluorometric microplate enzyme assays conducted with saltmarsh soils

Abstract Fluorometric enzyme assays are a tool for determining potential enzyme activity in soils. A wide array of methodological approaches is adopted by different studies, making comparisons difficult. An important consideration is whether assay conditions replicate the environ...

The Price of Resilience: Input-Cost Shocks in European Supply Chains under EU Sanctions on Russia

Version 1.1, 17.09.2026. Abstract Do broad-based sanctions break supply chains, or can open economies absorb geopolitical shocks through costly substitution? This paper studies the 2022 EU sanctions against Russia as a quasi-experimental input-cost shock to European manufacturing...

Integrated longitudinal analysis of ctDNA, radiologic response, and tumor volume reveals spatial and temporal heterogeneity in advanced melanoma

Abstract Background In advanced melanoma, longitudinal disease monitoring remains limited by infrequent biomarker assessment and predominantly categorical imaging readouts. Although circulating tumor DNA (ctDNA) correlates with tumor burden, its behavior under high-frequency samp...