The University of Sydney

Cognitive Behavior vs Bright Light Therapy for Insomnia in Women Undergoing Chemotherapy for Breast Cancer

Importance Women receiving chemotherapy for breast cancer experience insomnia and fatigue, which impair quality of life. To date, no randomized clinical trial (RCT) has evaluated the use of cognitive behavior therapy for insomnia (CBT-I) and bright light therapy (BLT) both alone...

dioscRi enables transferable prediction of clinical outcomes in multi-parameter cytometry data

Abstract Multi-parameter cytometry technologies enable high-dimensional analysis of immune cell populations at single-cell resolution. Deep learning has emerged as a transformative tool for analyzing these datasets, but existing methods often struggle with transferability across...

The effect of augmented protein intake on nitrogen balance: A nested cohort study of the TARGET protein trial

Purpose The impact of augmenting enteral protein delivery on nitrogen balance, urea generation, and kidney function in critically ill patients remains poorly defined. This study aimed to investigate these effects in a nested cohort within the TARGET Protein trial. Methods We cond...

Compassion in Mental Health Nursing: A Scoping Review

Compassion is widely recognised as a core component of mental health nursing, yet its meaning and application within this specialty remain underexplored. This scoping review examined how compassion is conceptualised, experienced, and enacted in mental health nursing practice, and...

Prevalence of Healthy Eating Initiatives in Australian Primary Schools: A Cross‐Sectional Survey

ABSTRACT Issue Addressed Schools are recommended settings for promoting healthy eating, but to achieve population‐level impact, initiatives must be widely implemented. Limited data are available to assess the implementation of Australian school‐based healthy eating initiatives. T...

Modeling the influences of non-local connectomic projections on geometrically constrained cortical dynamics

The function and dynamics of the cortex are fundamentally shaped by the specific wiring configurations of its constituent axonal fibers, also known as the connectome. However, many dynamical properties of macroscale cortical activity are well captured by instead describing the ac...

Why sexual violence and harassment are not addressed: comparative insights from Cambodia's construction sector

Purpose This article assesses whether workplace formality determines how sexual violence and harassment (SVH) complaints are interpreted, understood and addressed by workplace intermediaries in three cement factories and on 39 construction sites in Cambodia. Design/methodology/ap...

Effects of mandibular advancement device versus continuous positive airway pressure on cardiac remodeling in obstructive sleep apnea: a randomized CMR substudy

Obstructive sleep apnea (OSA) is associated with adverse cardiac remodeling, including diffuse myocardial fibrosis. Continuous positive airway pressure (CPAP) is the standard treatment for OSA, while mandibular advancement devices (MAD) may represent an alternative. However, thei...

Concentrations of polychlorinated biphenyls and toxic metals in short-tailed shearwaters following a mass mortality event

In 2013, a mass mortality event resulted in the deaths of approximately three million short-tailed shearwaters ( Ardenna tenuirostris ) along the east coast of Australia. As pelagic apex predators within their marine ecosystems and extensive migratory routes, these seabirds may s...

A serum protein–to–bilirubin ratio predicts immune-mediated hepatotoxicity in lung cancer patients treated with immune-checkpoint inhibitors

Immune checkpoint inhibitors (ICIs) have transformed outcomes for patients with advanced non-small cell lung cancer (NSCLC) but are associated with immune-related adverse events, including hepatotoxicity. Immune-mediated liver injury can necessitate treatment interruption and imm...

Integration of lipidomic and polygenic risk scores within contemporary clinical cardiovascular risk assessment pathways: a multi-cohort development and validation study

Background Guideline-recommended clinical risk scores such as AusCVDRisk underestimate cardiovascular disease (CVD) risk in a substantial proportion of individuals who later experience events, with up to 65% initially classified as low or intermediate risk. This limitation is mos...

Beyond Knowledge Transfer: Caregivers’ Evolving Medication Information Needs Across Paediatric Oncology Treatment

AIM: To identify and describe the medication information needs and preferences of caregivers of children with cancer, and the factors that support or impede those needs being met. DESIGN: Qualitative descriptive study guided by reflexive thematic analysis. METHODS: Between Novemb...

Digital Intermediation in Skilled Health Worker Migration: Platforms for Peer Support and Brokerage

Digital infrastructures have become important elements of the sociotechnical assemblages that mediate contemporary migration trajectories. Although digital platforms, tools and networks can be used to surveil and control migrants, they also afford migrants possibilities to self-o...

The impact and evolution of environmental/occupational, behavioural, and metabolic risk factors on CVD burdens in the Asia–Pacific region from 1990 to 2023: a secondary analysis of the Global Burden of Disease Study 2023

Background Understanding epidemiological trends of the cardiovascular risk factors is integral in designing effective countermeasures in tackling cardiovascular diseases (CVD) in the Asia–Pacific. The study aims to examine the cardiovascular risk factor burden in the Asia–Pacific...

Unlock the Potential of Pichia in Coffee: Knowledge Transfer From Fermented Beverages

ABSTRACT Considerable research has focused on non‐ Saccharomyces yeasts to explore their biochemical potential and genetic diversity beyond the capabilities of the conventional starter culture, Saccharomyces cerevisiae . Among these, species of the genus Pichia have emerged as pr...

Increasing humidity progressively reduces sweating efficiency similarly in males and females during exercise-heat stress

This study compared the impact of increasing relative humidity (RH) on sweating efficiency (SE) in males and females exercising in the heat. Twenty recreationally active adults (10 females) completed four experimental trials (15, 35, 55, or 75% RH) in an environmental chamber (35...

Temporal frictions in Australian horticultural value chains: Nature's time, power asymmetries and environmental consequences

The interdisciplinary agrifood literature has paid significant attention to power imbalances between supermarkets and suppliers, identifying fresh produce growers as particularly vulnerable to exploitative procurement practices. However, less work has examined the temporal charac...

Language impairments in behavioural variant frontotemporal dementia: a comparative study with semantic dementia

Abstract Introduction Recent evidence suggests that individuals with behavioural variant frontotemporal dementia (bvFTD) may experience language changes in a similar, but less severe manner, than what is observed in semantic dementia (SD). Few studies, however, have specifically...

Partitioning secreted sweat in the measure of sweating efficiency during exercise

Sweating efficiency (SE), defined as the proportion of total secreted sweat that evaporates from the body, is a critical determinant of evaporative heat loss and fluid requirements during exercise. Despite its physiological importance, direct assessments of evaporated sweat loss...

Oxygen minimum zones in the Indian Ocean and their response to changes in the Indian Ocean meridional circulation

Abstract. The Oxygen Minimum Zones (OMZs) in the northern Indian Ocean (i.e., the Arabian Sea and the Bay of Bengal) are among the most intense OMZs in the world's oceans. While there has been no clear evidence of a significant change in the Bay of Bengal OMZ (BoB OMZ), the Arabi...