The University of Sydney

Prenatal Genomics for Sonographers: Enhancing Confidence, Communication, and Clinical Care

ABSTRACT Genomic medicine is advancing rapidly, bringing significant changes to prenatal care and expanding the role of health professionals. As clinicians responsible for performing prenatal ultrasounds which may detect fetal anomalies and ultimately lead to genetic diagnoses, s...

Dissolved organic matter composition and mineral surface chemistry modulate organic retention and formation of mineral associated organic matter

The interaction between dissolved organic matter (DOM) and minerals governs OM stabilisation in soils. Heterogeneous composition of DOM and diverse mineral surface characteristics in soils make it challenging to determine reaction mechanisms at mineral-organic interfaces. To dete...

Stochastic generation of velocity fields to reproduce the energy spectrum in wall turbulence

Leveraging experimental measurements in rough-wall turbulent boundary layers that provided the spatial distribution and statistics of uniform momentum zones (UMZs), we previously introduced a stochastic model to generate two-dimensional modal velocity fields representative of the...

Functional Assessment of a Constitutively Activating CASR Variant Causing Autosomal Dominant Hypocalcaemia

Abstract Context A rare cause of hypocalcaemia, autosomal dominant hypocalcaemia type 1 (ADH1) arises from a gain-of-function variant of the calcium sensing receptor gene (CASR). Objective Three patients from two unrelated families, presenting with hypocalcaemia and other biochem...

TrivalentAl Insertion into Layered-Oxide-DerivedPerovskite Oxynitrides for Defect-Controlled Dielectric Response

Abstract Al-containing perovskite oxynitrides, SrAl0.2M0.8O2.4N0.6 (M = Nb, Ta), were synthesized by ammonolysis of layered Sr5M4O15 precursors with α-Al2O3. This reaction demonstrates that the cation-insertion chemistry of layered-perovskite-derived oxynitrides can be extended t...

Maximising the ‘co’ in co-design through facilitator actions: co-designers’ perspectives on what makes their participation in co-design meaningful

Co-design is a participatory approach to service development and research that is increasingly expected within the mental health sector. It involves end users being involved throughout a design process, not simply by providing opinions, but through shared decision making. Evidenc...

Shifting the Paradigm: From ‘Best Practice’ to ‘Best Beliefs’ for Autism Within Inclusive Early Childhood Education

Abstract This study explores the role of early childhood teachers’ beliefs in shaping inclusive practices for autistic children within Australian early childhood education and care (ECEC) settings. While national frameworks such as the Early Years Learning Framework (AGDE, 2022)...

Optimizing Informed Consent for Australian Newborn Bloodspot Screening and Research: Consensus Workshop Insights and Recommendations

Informed consent is fundamental to Australian newborn bloodspot screening (NBS), but emerging genomic screening technologies pose new challenges to clinical care and research. Optimizing consent processes is necessary to support ethical practice and maintain public trust as NBS e...

I Will Listen to Your Emotions, But I Will Hide My Own: People’s Different Strategies to Regulate Their Own Versus Others’ Emotions

Abstract: We can regulate our own and other people's emotions, but it is not clear whether we use the same strategies to regulate others’ emotions as we do to regulate our own. In three preregistered studies, we compared participants’ preferences for eight different emotion regul...

Enhanced Reactivation of Non-Pyrophoric Lanthanum-Modified AB2 Alloys for Hydrogen Storage

Abstract AB2 as hydrogen storage materials could provide an alternative path to compressed and liquid hydrogen for stationary applications. However, applications of these alloys are limited by the highly pyrophoric nature of AB2 powders once hydrogen-activated. Self-ignition and...

Treatment Goals for Primary Biliary Cholangitis, an Australian Perspective

ABSTRACT Primary biliary cholangitis (PBC) is an autoimmune liver disease that targets the small intrahepatic bile ducts with diagnosis based on elevated serum alkaline phosphatase (ALP) levels and the presence of anti‐mitochondrial antibodies. Untreated, it may run a progressive...

Patient-Specific Sensitivity of Osteotomy Interface Modelling in Mandibular Reconstruction

This study systematically investigates the influence of different interface modelling assumptions on biomechanical predictions using patient-specific models and evaluates their agreement with postoperative configurations. Five mandibular reconstruction cases using vascularised os...

Transdiagnostic symptoms of psychopathology interact with changes in environmental uncertainty

Abstract Uncertainty is a potential driver of poor mental health outcomes, and uncertainty is mounting across domains of daily life. It remains unclear how symptoms of anxiety and depression emerge in response to uncertainty in real-life contexts. The current study investigated h...

Predictive validity of the Addenbrooke’s cognitive Examination III for on-road driving outcomes in a clinical fitness-to-drive population: a prospective cohort study

Background Evidence-based fitness-to-drive assessment must balance public safety and fairness. Cognitive screens are commonly used, but must be accurate in high-stakes contexts. The predictive utility of the Addenbrooke’s Cognitive Examination III (ACE-III) for driving outcomes r...

Issues in the clinical assessment and management of people living with motor neurone disease (MND): a survey of Australian healthcare professionals

Objective: To inform the development of the Australian MND Guideline, this study aimed to identify challenges Australian healthcare professionals (HCPs) face in the clinical assessment and management of people living with MND (plwMND) including where practice varies from evidence...

Factors associated with bowel cancer screening participation among First Nations Peoples receiving home health care services in New South Wales, Australia

First Nations Australians consistently exhibit lower bowel screening participation rates than non-First Nations Australians. However, limited studies have been conducted to understand the factors associated with bowel cancer screening participation among First Nations Australians...

Newcastle disease virus is a safe and immunogenic respiratory-delivered vaccine against SARS-CoV-2 in a ferret model

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused close to 800 million infections and over 7 million deaths worldwide. In addition to its impact on human health, the virus has shown cross-species transmission, including spillover into mustelids such as m...

Terminology for describing the 24-h cycle of physical activity, sedentary behaviour, and sleep: a scoping review

Abstract Background Physical activity, sedentary behaviour, and sleep are three behaviours which occupy the 24-h cycle and interact to influence a multitude of health outcomes. Different terms are currently used to describe these behaviours collectively (e.g., movement behaviours...

Why are there so many different guidelines? A qualitative study of the low back pain policy landscape in Australia

Low back pain is a major cause of disease burden around the world. The sheer number and variety of back pain guidelines developed in Australia suggests that there are drivers within the low back pain care landscape to promote development of guidelines which are produced by a wide...

Approved Monoclonal Antibody Therapies for Hidradenitis Suppurativa

Importance Biologic therapies are increasingly used for moderate to severe hidradenitis suppurativa (HS), yet their high cost presents challenges for health systems and payers. Comparative economic evaluations of these therapies are limited. Objective To evaluate the efficiency f...