The University of Sydney

Implementation and Management of Cancer Clinical Quality Registries in Australia: A Qualitative Study

ABSTRACT Background In Australia, clinical quality registries (CQRs) for cancer care are becoming increasingly common, requiring integration across multiple sectors of the health system. This study sought to identify the means to successful implementation of CQRs in Australia by...

ANZTCT cytomegalovirus practice survey for allogeneic haemopoietic stem cell transplant and cellular therapy recipients in Australia and New Zealand

BACKGROUND: Despite pre-emptive treatment (PeT), cytomegalovirus (CMV) disease and reactivation remain a clinical concern. In Australia and New Zealand (ANZ), variability exists in the management of CMV for haematopoietic stem cell transplantation (HSCT) recipients. AIMS AND METH...

Enhancing advertising novelty through celebrity cameo endorsement

Celebrity endorsement is a widely used tool in strategic marketing, yet questions remain about how to enhance its novelty and ad effectiveness. We introduce and test a novel executional tactic: celebrity cameo endorsement: a brief appearance by a new known figure alongside an exi...

Trajectory of macrotroponin in a community cohort

BACKGROUND: Cardiac troponin I (cTnI) is a biomarker for myocardial injury. However, macrotroponin, a complex of cTnI and endogenous cardiac troponin autoantibodies, may artefactually elevate cTnI levels with potential to mislead clinicians, leading to inappropriate investigation...

Adaptation and pilot implementation of the WHO guideline on digital intervention to strengthen mental health systems in Lagos state, Nigeria

Abstract Background The uptake and implementation of cost-effective interventions and programs for mental health problems are often threatened by weakened health systems (HS) in low- and middle-income countries (LMICs). Digital technologies provide concrete opportunities to tackl...

Combining Implementation and Data Sciences to Accelerate Evidence Integration into Healthcare – ImpleMATE

Background The translation of research evidence into routine healthcare practice is often slow and inconsistent, even timely implementation can significantly improve patient outcomes. While implementation science offers strategies to close this gap, current approaches are frequen...

Towards Improved P2X7R Cellular Models for Alzheimer’s Disease Drug Discovery

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with no disease-modifying therapeutics. The P2X7 receptor (P2X7R) presents as a promising target for AD drug discovery due to its pathogenic role in the onset and progression of neuroinflammation, a hal...

Management of Soft Tissue and Visceral Leiomyosarcomas

Importance Leiomyosarcoma is a rare and heterogeneous malignant mesenchymal neoplasm associated with substantial morbidity and mortality. Given recent advances in biologic understanding and the complexity of leiomyosarcoma, a consensus-driven approach is needed to harmonize manag...

In Situ TEM Study of the Size-Dependent Solubility of Metals in Liquid Metal Nanodroplets

Abstract Characterizing metal solubilities in post-transition-based liquid metals remains challenging due to their inherent opacity to conventional light-based analytical techniques. In this work, we present an in situ heating methodology within a transmission electron microscope...

International consensus guidance for general population screening for islet autoantibodies to diagnose early-stage type 1 diabetes: a nominal group technique process

Type 1 diabetes is an autoimmune disease that targets and destroys insulin-producing beta cells in the pancreatic islets. The incidence of type 1 diabetes is rising globally. At the clinical diagnosis of type 1 diabetes, between 20% and 67% of children and adolescents present wit...

Implementing a patient decision aid about selective dorsal rhizotomy in clinical practice: pre-post pilot study

PURPOSE: To evaluate whether implementing a patient decision aid about Selective Dorsal Rhizotomy (SDR) for carers of children with bilateral spastic cerebral palsy (CP) improves carer decision-making outcomes and is acceptable to healthcare providers, and to explore carers' expe...

Housing displacement experiences following major flooding in regional Australia: A qualitative study of online news articles

Background The health impacts of flood displacement are increasingly acknowledged within broader literature. However, there remains limited research on the challenges of accessing post-flood accommodation and how these influence health and wellbeing, particularly mental health. T...

Combined Idiopathic Intracranial Hypertension score, an integrated severity and treatment-oriented tool for idiopathic intracranial hypertension: a retrospective cohort study

IIH has evolved into a multidisciplinary condition managed across neurology, ophthalmology, interventional neuroradiology, and surgery. Existing tools address only partial aspects of disease severity; no unified, treatment-oriented classification exists to support multidisciplina...

Assessment of organizational readiness for implementing an online pain education program for chronic musculoskeletal pain in Brazilian public health context: a cross-sectional study

Understanding the organizational readiness for behavior change is paramount for implementation success of new interventions and to avoid waste of resources. To assess organizational readiness of primary healthcare providers to refer users with chronic musculoskeletal pain for an...

Localized Covariant Quantities Appear to Underlie Quantum Circuits

Although entangled state vectors cannot be fully described in terms of variables localized in space and time, any given entanglement experiment can be built from basic quantum circuit components with well-defined locations. We analyze such quantum circuits and present evidence th...

Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials

BACKGROUND: Narcolepsy type 1 is characterized by excessive daytime sleepiness, cataplexy, disrupted sleep, sleep paralysis, and hypnagogic or hypnopompic hallucinations. Oveporexton (TAK-861), an oral orexin receptor 2-selective agonist, reduced symptoms of narcolepsy type 1 in...

Clinicians' Perspectives and Experiences of Barriers, Enablers and Implementation of a Child and Adolescent Mental Health Crisis Service: A Qualitative Evaluation of the Safeguards Team Program

BACKGROUND: Presentations of children and young people (CYP) to Emergency Departments (ED) for acute mental health (MH) issues have increased globally and in Australia. The Safeguards Teams Program (STP) was implemented to provide acute, rapid response, recovery-focused, trauma-i...

Metal–Metal Interactions in Hexagonal Perovskites Containing Bimetallic Face-Sharing Bioctahedra

Abstract Recent studies have revealed metal-to-metal and intervalence-charge transfer transitions in cation ordered 6H perovskites with Cs3M+M2+M3+Cl9 stoichiometry. The structure and properties of two new members of this family, Cs3NaMnVCl9 and Cs3NaMnCrCl9, are reported here. I...

Oxygen vs Air at Birth for Moderate- to Late-Preterm Infants

Importance The optimal initial fraction of inspired oxygen (F io 2 ) for delivery room resuscitation of neonates born at 32 to 35 weeks’ gestation is unknown. Objective To compare outcomes for neonates born at 32 to 35 weeks’ gestation when initiating resuscitation with F io 2 0....

Health beliefs and health seeking behaviour among families of children with a respiratory illness in Cape Town, South Africa: lessons learnt from the COVID-19 pandemic

Globally, acute respiratory infections(ARIs)are one of the leading causes of mortality and morbidity in children and the most common causes of visits of children to health facilities. Pandemics can unintentionally negatively impact on health beliefs and health-seeking behaviour,...