The University of Sydney

BenchHub enables an inclusive and transparent ecosystem for community-focused benchmarking in computational biology

Abstract Background The rapid growth of computational methods for the computational biology field highlights the critical role of benchmarking in guiding method selection. However, there is no standardised data structure that effectively links and stores datasets, performance met...

Clinicians' Perspectives and Experiences of Barriers, Enablers and Implementation of a Child and Adolescent Mental Health Crisis Service: A Qualitative Evaluation of the Safeguards Team Program

BACKGROUND: Presentations of children and young people (CYP) to Emergency Departments (ED) for acute mental health (MH) issues have increased globally and in Australia. The Safeguards Teams Program (STP) was implemented to provide acute, rapid response, recovery-focused, trauma-i...

Performance of point‐of‐care tests for diagnosing feline immunodeficiency virus infection in captive African lions ( Panthera leo )

Point-of-care (PoC) antibody (Ab) testing forms an integral component of feline immunodeficiency virus (FIV) diagnosis in both domestic and non-domestic felids, with test kits designed for use in domestic cats frequently extrapolated for use in their wild counterparts. The SNAP®...

Assessing organisational commitment and readiness through the DANMM project: a mixed-methods study

Background Low representation and retention of Aboriginal and Torres Strait Islander nurses and midwives remain a persistent challenge for Australian health systems, constraining delivery of culturally safe, person-centred care. Building and sustaining this workforce is essential...

Combinations of stepping intensity and daily step counts against all-cause and cardiovascular disease mortality: insights from a device-based prospective study

Objective Understanding the joint role of stepping intensity and step counts could inform pragmatic step-based physical activity strategies for premature mortality prevention. We examined the joint association of stepping intensity and daily step counts with all-cause mortality (...

High-dimensional inverse design enables multiple synthesis routes to prescribed carbon nanotube array descriptors

Abstract Prescribed synthesis of carbon nanotube (CNT) arrays remains challenging because multiple processing stages jointly regulate array height (H), density (ρ), and orientational order (HOF), creating a nonlinear and non-unique relationship between structural targets and synt...

Small mammalian herbivores at moderate densities facilitate livestock growth by improving vegetation composition in grasslands

Small mammals and large herbivores have co-evolved in grasslands for millions of years, yet how they interplay remains unclear. Although large herbivores can significantly affect the smaller ones, the reversal effect is largely unknown. On the Qinghai–Tibetan Plateau, plateau pik...

Corals Versus the Crown-of-Thorns Sea Star in the Anthropocene

Coral reefs are experiencing rapid transformation under interacting pressures of climate change, direct human impacts, and biological disturbance. Outbreaks of the corallivorous crown-of-thorns sea star (COTS; Acanthaster spp.) are major drivers of coral mortality. In parallel, c...

A CRISPR‐Based Rapid Detection Assay for Crayfish Plague ( Aphanomyces astaci ) From Environmental Samples

Crayfish plague, caused by Aphanomyces astaci (Aa), is an infectious disease invasive in Europe, where its rapid spread has resulted in sharp declines of native crayfish species. Monitoring currently relies on a highly sensitive, but costly and time-consuming qPCR approach. Here,...

Soil Security Debt: The Hidden Liability Beneath Food, Water, Climate and Land Systems

Soil degradation is commonly quantified using state or trend indicators, but these measures do not show whether a shortfall has accumulated through time, created a deferred obligation, or transferred costs and risks across actors, places, sectors or generations. This Concept Pape...

Sclerotherapy in Orbital and Peri-Orbital Pathology: A Systematic Review of Current Applications and Emerging Frontiers

Aim To highlight current and emerging applications of sclerotherapy in orbital and peri-orbital pathology while identifying evidence gaps and future directions.Methods Systematic review of 108 studies identified through PubMed, Embase, Scopus, and Web of Science databases from in...

Level IA Nodal Involvement in Parotid Cutaneous Squamous Cell Carcinoma

ABSTRACT Background The frequency of Level IA metastasis in advanced cutaneous squamous cell carcinoma (cSCC) remains undefined yet determines the oncological safety of submental island flap (SIF) reconstruction. Methods A retrospective cohort study was performed on 131 adults wh...

Time as a cue for human hunger

Many people eat at around the same times each day. This may result in meal times becoming predictive of eating's potential to be rewarding at that time (i.e., hunger). Time as a predictor of food reward has received much attention in animals but less in humans, even though many p...

Silica secrecy: Navigating access to silica dust data under freedom of information legislation

Abstract Tunnel construction supports vital infrastructure development but can expose workers to serious health risks, including silicosis, from exposure to respirable crystalline silica (RCS). This study examines how Australia's freedom of information (FOI) legislation facilitat...

A divergent betacoronavirus with a functional furin cleavage site in South American bats

Abstract Bats are natural reservoirs for a wide range of RNA viruses. Members of the genus Betacoronavirus , including Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) and Middle East Respiratory Syndrome virus (MERS-CoV), have attracted particular attention due to their re...

Replication of sex differences in tobacco smoking-induced dopamine responses and extension to nicotine replacement therapy

Abstract Introduction Tobacco smoking is a major public health risk, and treatment efficacy differs by sex. Previous imaging studies reported sex differences in smoking-induced striatal dopamine release, but no PET study has independently replicated these findings. We applied a n...

Emergency Department Implementation of Care Models for Individuals Experiencing Family and Domestic Violence and Abuse: A Systematic Scoping Review

Family and domestic violence and abuse (FDVA) is a major public health issue. Emergency Departments (EDs) are critical points of contact: women affected by intimate partner violence attend EDs at triple the rate of unaffected women, and 44% of women killed by a partner presented...

Relationship between data bias and model fairness in machine learning

Ensuring fairness in machine learning (ML) applications remains a critical challenge, particularly in high-stakes domains such as healthcare, finance, and criminal justice. Bias in training data is widely considered a key driver of unfair outcomes. However, the relationship betwe...

Predictors and prediction models for complications of early medical abortion: a scoping review

Background Despite its overall safety and efficacy, early medical abortion (EMA) may result in complications. Understanding factors predicting these complications is essential for improving clinical risk assessment by healthcare providers and guiding effective management of compl...

Efficacy and safety of canagliflozin are consistent across polypharmacy burden in CKD: the CREDENCE trial

Abstract Background Polypharmacy in chronic kidney disease (CKD) is substantial. Clinicians and patients are often reluctant to add medications to already complex regimens, partly due to concerns about diminishing efficacy and increased adverse effects. We assessed whether effica...