The Ohio State University

Continuous Glucose Monitoring Hypoglycemia Alarms in Critical Care: Clinical Utility and Workflow Integration

Background: Continuous glucose monitoring (CGM) has been associated with reductions in inpatient hypoglycemia; however, little is known about the performance and integration of CGM hypoglycemia alerts and alarms in the intensive care unit (ICU). We evaluated hypoglycemia signal f...

Landscape of approaches for streamlining pre-analytical and early analytical variables for solid tumor next-generation sequencing: A Genomics Organization for Academic Laboratories consortium report

The scope of pre-analytical and early analytical methods used in clinical molecular laboratories can have vast effects on the quality and turnaround time for solid tumor next-generation sequencing assays. To learn more about various approaches, a survey of 24 academic laboratorie...

Can Knowledge Counteract Conflict? A Partial Replication Study of PFAS Science Communication

ABSTRACT On the basis of two surveys embedded with a 3 × 2 full‐factorial experiment, we examine whether exposing participants to a message about the process of scientific inquiry prepares them to deal with conflicting risk information more effectively. Study 1 suggests initial e...

AI Accelerated Chemical Screening Integrates ChemBERTa to Identify Repositionable CASP4 Inhibitors via MD Simulations and MM/PBSA Analysis

Abstract This study employed an integrated ligand-based virtual screening pipeline to identify potential CASP4 inhibitors from the DrugBank database, leveraging docking-score prioritization, SMILES-derived ChemBERTa embeddings, and key physicochemical descriptors. Building on thi...

Linking public and private neuroimaging data with decentralized analysis via NeuroFLAME Vaults

Large-scale datasets and global collaborations are increasingly enabling exciting discoveries in neuroimaging research; however, barriers such as data privacy regulations and unequal access to computational infrastructure continue to hinder progress. Federated analysis offers a p...

Epidemiology of Postoperative Pneumonia in Pediatric Inpatient Surgery: An ACS NSQIP-P Analysis

OBJECTIVE: Postoperative pneumonia (POP) is a serious surgical complication associated with increased morbidity, mortality, and health care costs. Although well described in adult surgical populations, the epidemiology of POP in children remains less clearly defined. Our objectiv...

Endocrine, Skeletal, and Circadian Biomarker Profiles Across Operational Phases in Elite Special Forces Operators

Abstract Kraemer, WJ, Volek, JS, Stephenson, MD, Szivak, TK, Saenz, C, Buga, A, Lee, EC, Ratamess, NA, Post, EM, Caldwell, LK, Hagen, JA, and Maresh, CM. Endocrine, skeletal, and circadian biomarker profiles across operational phases in elite special forces operators. J Strength...

Longitudinal plasma neurofilament light chain and patient-reported outcomes as complementary markers of vincristine-associated peripheral neuropathy in adults with lymphoma: a cohort study

Abstract Chemotherapy-induced peripheral neuropathy (CIPN) is a common neurotoxicity of cancer treatment with limited diagnostic, monitoring, and treatment options. Neurofilament light chain (NfL) is an axonal cytoskeletal protein released during neuroaxonal injury and a promisin...

Anomalies in regional cortical morphology and associations with neurocognitive function in children with prenatal cannabis exposure and unexposed comparisons

Prenatal cannabis exposure (PCE) is associated with neurocognitive impairments in childhood, but the underlying neurodevelopmental process remains unclear. In analysis of a subset of data from a prospective cohort of children (age 7–8 years, n = 56) with and without PCE in the US...

Utility of IL ‐18 Immunohistochemistry in Distinguishing Dermatomyositis and Lupus Erythematosus in Skin Biopsies

ABSTRACT Background Distinction of dermatomyositis ( DM ) and cutaneous lupus erythematosus ( LE ) in skin biopsies is often difficult due to significant histopathologic overlap. Prior transcriptional analysis has identified upregulation of IL ‐18 in DM compared with LE . We aime...

Optimizing daily spontaneous breathing trial timing to expedite extubation

Background Spontaneous breathing trials (SBTs) are a crucial tool used to assess patients who are being mechanically ventilated for extubation readiness. Objectives As a quality improvement initiative, we have conducted a pre-post implementation study to evaluate whether changing...

Inflammatory Cytokines as Biologic Signatures of the Effect of Dietary Supplementation With Omega Fatty Acids on Autism-Related Behaviors and Features Among Young Children: A Randomized Controlled Trial

Abstract Purpose Evidence for the efficacy of dietary omega fatty acid supplementation as a supportive intervention for autism is mixed. Mechanisms by which supplementation may offer benefit are unclear. Inflammation may contribute to autism-related behaviors and features. This d...

Long-term Career Outcomes and Associations With Academic Careers, Leadership, and Publication Volume After Hand Fellowship

Background: We aimed to characterize career outcomes among fellowship-trained hand surgeons in the United States with a focus on academic careers and factors associated with leadership roles and post-fellowship publication volume. Methods: Of 94 programs in the American Society f...

A peer-based reflexive study on counselor educator social justice advocacy

This study explored the lived experiences of counselor educators who strive to integrate social justice advocacy (SJA) amidst systemic challenges. While SJA is an important function in the field, actualizing this vision often involves tension, resource strain, and professional ri...

In Search of Subtypes of Children With Developmental Disabilities Using the WISC-V: A Latent Profile Analysis

Abstract Purpose Identifying subtypes within autism spectrum disorder (ASD) has often been attempted to better understand the significant heterogeneity within the spectrum. Profiles of cognitive functioning have frequently been investigated as possible subtype definitions, but mo...

“You Gotta Eat It to Survive”: A Mixed-Methods Study of the Perceived Food Environment and Food Choice Among Youth Experiencing Homelessness

Background/Objectives: This study aimed to examine how the perceived food environment influences food choice among youth experiencing homelessness. Methods: A convergent parallel mixed-methods design was used with 14 youth experiencing homelessness (aged 18–23 years; 64% Black/Af...

Quenching Kinetics of Triplet-State Photosensitizers in Environmental Photochemistry

Abstract Triplet-state photosensitizers (3Sens*) are central to carbon cycling and pollutant degradation in sunlit surface and atmospheric waters, but their environmental roles remain only partly understood. Although the photophysical and photochemical properties of 3Sens* have b...

The Python simulations of chemistry framework: 10 years of an open-source quantum chemistry project

Over the past decade, the Python-based Simulations of Chemistry Framework (PySCF) has developed into a widely used open-source platform for electronic-structure theory and quantum chemical method development. This article reviews the major advances since the previous overview in...

Development and Validation of the Stress Burden of Electronic Cigarette Smoking Scale (SBECSS) Among Adult Dual Users

BACKGROUND: The present study aimed to develop and evaluate the preliminary validity of the Stress Burden of Electronic Cigarette Smoking Scale (SBECSS), a new measure designed to assess the level of stress burden associated with the co-occurring perceptions of electronic cigaret...

Metal–Metal Interactions in Hexagonal Perovskites Containing Bimetallic Face-Sharing Bioctahedra

Abstract Recent studies have revealed metal-to-metal and intervalence-charge transfer transitions in cation ordered 6H perovskites with Cs3M+M2+M3+Cl9 stoichiometry. The structure and properties of two new members of this family, Cs3NaMnVCl9 and Cs3NaMnCrCl9, are reported here. I...