The Ohio State University

MicroRNA-driven regulation of immunosuppressive microenvironment in hepatocellular carcinoma

We investigated the role of tumor microenvironment (TME) in evolution of liver cirrhosis to hepatocellular carcinoma (HCC). Nonmalignant hepatic tissues, including chronic hepatitis and cirrhosis, retained expression of liver specific miR-122 and hepatocyte nuclear factor 4 (HNF-...

Boundary Control and Obtaining Care: Which Workplace Policies Are Associated with Obtaining Preventative Care During Work Hours?

CONTEXT: Because preventative care is often only available during standard business hours, workplace policies and work arrangements may play a central role in enabling people to obtain needed care. Yet it remains unclear which specific policies and practices are most effective in...

Investigating Variability and Malleability of Speech-Language Pathologists' Responsive Talk With Children: An Early-Efficacy Trial

Purpose: The purposes of this early-stage efficacy study were to examine speech-language pathologists' (SLPs') use of responsive talk with children and to determine the extent to which responsive talk can be modified through brief clinician education or an in situ, tablet-based f...

Microbial Surveillance of Commonly Encountered Clinical Surfaces Within a Veterinary Ophthalmology Service

ABSTRACT Objective To establish surveillance of organisms found on high‐touch clinical surfaces within a veterinary teaching hospital ophthalmology service and record trends that may foster additional studies investigating links between environmental microbiota and pathogenic bac...

Diabetes and Suicide Risk Among Black Males, Including Sexual Minority Males: A Narrative Review With Primary Care Implications

Abstract Purpose of Review Diabetes and suicide are intersecting public health concerns, yet evidence at this intersection remains sparse for Black males and especially Black sexual minority males (SMM). This focused narrative review synthesizes direct and adjacent evidence, with...

Influence of Positive Childhood Experiences Profiles on Bullying Victimization and Perpetration in Youth: A Latent Class Analysis

Bullying has enduring negative effects on development in adolescents. While research has focused on reducing risk factors such as adverse childhood experiences for bullying, growing evidence highlights the protective role of positive childhood experiences (PCEs) in fostering resi...

Place Character and the Local Welfare State: Counties' Social Services and Public Provisions Across Rural and Urban Communities

ABSTRACT Relatively little attention has been given to rural local governments' social safety net and public service provisions. We develop a framework to explain how the character of communities influence social and other public services provided by local governments and why rur...

In-situ remediation for arsenic-contaminated soils using iron and aluminum amendments under varying redox conditions

Arsenic (As) contamination can threaten groundwater quality and human health, particularly where redox conditions fluctuate. Although iron (Fe) and aluminum (Al) (hydr)oxides strongly adsorb arsenate under oxic conditions, flooding can promote As(V) reduction to more toxic and mo...

A Cautionary Tale – Every Set is an Interval Set and an Equiset

Given a metric space (X,d) with distinct points x,y∈X, we consider the interval set Id(x,y)={z∈X:d(x,z)+d(z,y)=d(x,y)} and the equiset Ed(x,y)={z∈X:d(x,z)=d(y,z)}. The topology and geometry of these regions have been studied, in particular when the metric arises from a norm. In t...

Living Well With Metastatic Breast Cancer: The Next Frontier for the Chronic Care Model?

Abstract Purpose of Review The overall survival of patients with metastatic breast cancer (MBC) is increasing, shifting it to a chronic condition for thousands of patients across the globe. We reviewed the literature to determine how to utilize the chronic care model for these pa...

Chronic Predation Risk Induces Sex‐Specific Effects in Behavior but Does Not Induce Long‐Term Oxidative Damage in the Threespined Stickleback

ABSTRACT Predation is a strong environmental and selective pressure that can favor rapid and plastic shifts in behavior and escape ability to increase an organism's immediate survival. However, maintaining antipredator responses under repeated predation stress can induce physiolo...

Reinventing human geography

David Harvey is the most significant contributor ever to the academic field of human geography as well as to how it might be practiced to advance progressive social causes. Among his contemporaries, he is easily the most cited, simply towering other human geographers. Through his...

Inhibition of PLK1 helps to restrict c-Met-induced growth and therapeutic resistance of renal cancer cells

Acquired therapeutic resistance is a major problem in the treatment of advanced renal cell carcinoma (RCC). The receptor tyrosine kinase (RTK) c-Met is hyperactive in RCC and plays a major role in the survival of tumor cells during therapy-induced oxidative stress. Although c-Met...

Metabolomic Changes in Biofilm of Pseudomonas aeruginosa Under Early-Stage Tobramycin Treatment Identified by 2D NMR-Based COLMARq

Abstract Biofilms are estimated to account for a large proportion of persistent microbial infections and are associated with substantial mortality in hospitals. Pseudomonas aeruginosa biofilms exhibit higher resistance to antibiotics compared to their planktonic growth form, maki...

Variations in diagnosis and management of hemodynamically significant patent ductus arteriosus across neonatal intensive care units in the Children’s Hospitals Neonatal Consortium

Abstract Objective Collate patent ductus arteriosus (PDA) guidelines among Children’s Hospitals Neonatal Consortium (CHNC) centers and identify variations in the diagnosis and management of hemodynamically significant PDA (hsPDA). Study Design: A descriptive survey requesting wri...

Randomized phase II trial of liposomal cytarabine and daunorubicin with or without pomalidomide in newly diagnosed acute myeloid leukemia myelodysplasia-related

Not available.

Anomalous Pigmentation in Depigmented Murine Hairs from Neutron Radiation Exposure

Abstract Depigmentation in mouse hair is a long-studied consequential effect of radiation exposure. In this study, changes in hair pigmentation in C57BL/6 mice are observed at time points more than 90 days following neutron irradiation. A mixed sex cohort of C57BL/6 mice (N = 40)...

Interoceptive Accuracy, Metacognition, and Facial Trustworthiness Perception Across the Adult Lifespan

Abstract Older adults often exhibit more positive impressions when forming trustworthiness impressions based on facial appearance. These judgements influence social decisions in later interpersonal interactions and are thought to put older adults at greater risk of victimization....

Defining priorities for care among young adults diagnosed with breast cancer

Abstract Introduction Breast cancer is a leading cause of cancer‐related mortality among young adults (YAs) aged 18–39 years. Although the National Comprehensive Cancer Network recommends that YAs be treated at centers with age‐specific expertise, standardized care pathways are l...

Minimally Invasive Surgery for the Treatment of Lumbar Spinal Stenosis: A Comprehensive Review

Abstract Introduction Lumbar spinal stenosis (LSS) is a prevalent and debilitating condition characterized by the narrowing of the spinal canal, leading to pain and neurogenic claudication. While open laminectomy is the gold standard for severe cases, it carries significant risks...