The Ohio State University

Defining priorities for care among young adults diagnosed with breast cancer

Abstract Introduction Breast cancer is a leading cause of cancer‐related mortality among young adults (YAs) aged 18–39 years. Although the National Comprehensive Cancer Network recommends that YAs be treated at centers with age‐specific expertise, standardized care pathways are l...

Minimally Invasive Surgery for the Treatment of Lumbar Spinal Stenosis: A Comprehensive Review

Abstract Introduction Lumbar spinal stenosis (LSS) is a prevalent and debilitating condition characterized by the narrowing of the spinal canal, leading to pain and neurogenic claudication. While open laminectomy is the gold standard for severe cases, it carries significant risks...

On the Cost of Conforming to Reviewers’ Expectations and the Potential Benefit of Prediction Competitions

Although academic peer review offers many important benefits, it can also impede scientific exploration. For instance, when reviewers share restrictive working assumptions, researchers may be incentivized to conform to them, even when alternative conjectures could better advance...

Identifying potential factors influencing family-building perspectives in adults with SCD

Abstract Purpose The study aimed to identify factors influencing family-building perspectives among adults with sickle cell disease (SCD) overall and by sex, and to examine attitudes toward discussing SCD genetic transmission with partners and doctors by sex and relationship stat...

Co-creation with older adults in undergraduate design education: illustrative evidence from two Chilean cases in the Global South

This study explores the role of co-creation with older adults in undergraduate design education in Chile using a multi-case illustrative design. Two educational experiences that incorporated participatory design approaches are examined: a short-term User-Centered Design (UCD) wor...

Caspase-11–mediated hyperinflammation impairs CD8+ T cell immunity and viral clearance in severe SARS-CoV-2 infection

Severe SARS-CoV-2 infection is characterized by lung hyperinflammation, impaired IFN responses, and defective T cell activation, yet the molecular drivers of these immune dysregulations remain incompletely understood. Caspase-11 (CASP11), a key effector of the noncanonical inflam...

A Sequence-to-Scaffold Platform Enables Programmable Carrier-Supported Biocatalysis for Nucleoside Analog Synthesis

Abstract Industrial biocatalysis increasingly requires strategies that convert enzyme discovery into robust catalyst systems for process implementation. Here, we report Spatially Programmable Assembly of Computationally Mined Enzymes (SPACE), a sequence-to-scaffold workflow coupl...

Advancements in Managing Bone Defects with Limb Length Discrepancies with a Motorized Intramedullary Combined Transport and Lengthening Nail

Summary: Large bone defects that coexist with limb length discrepancy present a challenging problem in limb reconstruction. Historically, management has required complex circular fixation constructs, staged procedures, or separate devices to independently address each problem. Ho...

Looking back to look ahead: a BERTopic-assisted scoping review of Medical Humanities (2000–2025)

This study provides a scoping review of the periodical BMJ Medical Humanities in order to identify thematic changes evident in the journal between 2000 to 2025. Metadata for the review, including abstracts, publication years, authors and PubMed Identifiers (PMIDs), were gathered...

Comparison of Wavefront-optimised Refraction Determined Pre- and Post-cycloplegia in Individuals with Down Syndrome

Abstract Purpose To compare metric-optimised refractions determined from wavefront aberration measures with the COAS-HD wavefront aberrometer pre- and post-dilation and the resultant visual acuity through each refraction in participants with Down syndrome (DS). Methods Twenty-one...

MOCVD Growth of (011) β-Ga2O3 Films: Defect Control and Device Implication

Abstract β-Ga2O3 is a promising ultrawide-bandgap semiconductor for high-power electronics; however, the realization of thick, low-defect drift layers at high growth rates remains challenging. In this work, metalorganic chemical vapor deposition (MOCVD) growth of (011) β-Ga2O3 dr...

Validating and creating a short-form of the persisting effects questionnaire: A measure of positive and negative outcomes from psychedelic experiences

BACKGROUND: The persisting effects questionnaire (PEQ) is a measure of self-reported positive and negative effects from psychedelic and other experiences. While this measure has been used in many studies on psychedelic substances, the scale has not been formally validated. The PE...

A Causal Model for Prehospital Blood Transfusion and Mortality in Traumatic Hemorrhagic Shock

OBJECTIVES Utilization of prehospital blood transfusion (PBT) as a treatment for traumatic hemorrhagic shock (THS) has been expanding nationally, yet evidence supporting the practice in some operational environments remains limited. Development of strong scientific evidence to su...

Reproducibility of battery state of health estimation using short discharge tests across independent experimental platforms

Accurate estimation of battery state of health (SOH) is essential for practical battery diagnostics and for screening retired lithium-ion batteries for second-life applications. Although short-duration discharge-based data-driven approaches show promising performance, their repro...

PriME: Privacy-Aware Membership Profile Estimation in Networks

Abstract. This paper presents a novel approach to estimating communbity membership probabilities for network vertices generated by the degree corrected mixed membership stochastic lock model [ 36 ] while preserving individual edge privacy. Operating within the [Formula: see text]...

Structure of Li3YCl6 and Its Effect on Lithium Ionic Conductivity

Abstract Halide-based Li+ solid-state electrolytes have garnered renewed interest in recent years, mainly because of their significantly improved Li+ ionic conductivity and excellent stability against high-voltage cathodes. Numerous studies have reported that synthetic conditions...

Cross-Sectional Differences in Self-Harm Methods Across Childhood and Adolescence

This cross-sectional study compares self-harm methods across developmental stages from childhood through emerging adulthood.

The Positive and Adverse Childhood Experiences (PACE) Framework for Counseling Youths

ABSTRACT Youth mental and behavioral health are significantly shaped by both adverse childhood experiences (ACEs) and positive childhood experiences (PCEs). Yet, counseling scholarship and training often address these domains separately, limiting their translation to counseling p...

Continuous Glucose Monitoring Hypoglycemia Alarms in Critical Care: Clinical Utility and Workflow Integration

Background: Continuous glucose monitoring (CGM) has been associated with reductions in inpatient hypoglycemia; however, little is known about the performance and integration of CGM hypoglycemia alerts and alarms in the intensive care unit (ICU). We evaluated hypoglycemia signal f...

Can Knowledge Counteract Conflict? A Partial Replication Study of PFAS Science Communication

ABSTRACT On the basis of two surveys embedded with a 3 × 2 full‐factorial experiment, we examine whether exposing participants to a message about the process of scientific inquiry prepares them to deal with conflicting risk information more effectively. Study 1 suggests initial e...