The Ohio State University

Searching the Druggable Genome using Large Language Models

Summary: The druggable genome encompasses the genes that are known or predicted to interact with drugs. The Drug-Gene Interaction Database (DGIdb) provides an integrated resource for discovering and contextualizing these interactions, supporting a broad range of research and clin...

Intrawound Vancomycin Powder in Surgical Site Infection Prophylaxis: A Comprehensive Review of Mechanisms, Efficacy, Safety, and Clinical Controversies

Surgical site infections (SSIs) remain a critical postoperative complication that causes significant morbidity, mortality, and healthcare costs. To mitigate these risks, intrawound vancomycin powder has been increasingly adopted as a prophylactic option, particularly for high-ris...

Balancing efficiency and equity in classroom assignment under endogenous peer effects

This paper presents a three-step empirical framework for optimizing classroom assignments under endogenous peer effects, using data from the China Education Panel Survey (CEPS). We design \textit{PeerNN}, a neural network that mimics endogenous network formation as a discrete cho...

Inhibition of KDM5A/B promotes antitumor innate immune responses in HHV-8/KSHV-positive B-cell lymphomas

Histone methylation is a dynamic and reversible epigenetic modification that critically controls the progression of human diseases, including infections and cancers. Here we reported that histone lysine demethylases (KDMs) in the KDM5 family KDM5A/B play profound roles in suppres...

The paradox of human capital? Gendered precarious labor in the Korean Confucian gender regime

Purpose This study investigates the gendered dynamics of precarious labor in South Korea, an underexplored context in international scholarship. It examines how Confucian-influenced patriarchal norms relate to women's exposure to insecure employment despite rising educational att...

Ensemble agroecosystem modeling enhances predictions of crop yields and soil carbon across the United States

Abstract. Accurately estimating crop yields and soil organic carbon (SOC) dynamics is essential for agricultural planning, carbon accounting, and sustainable land management. However, process-based agroecosystem models often produce divergent estimates due to variations in model...

Conformal network link prediction with false discovery rate control under unstructured missingness

We propose a new method for predicting multiple missing links in partially observed networks while controlling the false discovery rate (FDR), a largely unresolved challenge in network analysis. The main difficulty lies in handling complex dependencies and unknown missing pattern...

Microbial inoculants for soil restoration: A Risk-Proportional Stewardship Framework Integrating Strain-Resolved Genomics and Adaptive Governance

Abstract Global soil degradation and increasing reliance on chemical inputs threaten agricultural sustainability, driving interest in microbial inoculants as tools for soil restoration. These biological products have the potential to enhance nutrient cycling, improve soil structu...

The Dialects of Lesvos and Adrianople: Similarities and Differences and What They Tell Us About Dialectal Variation in Greek

The Greek dialects of Lesvos and Adrianople (present-day Edirne) during the time of the Ottoman Empire have much in common. Both are northern dialects and show considerable influence from Turkish; moreover, both were documented in the early 20th century, before the fall of the Ot...

Development of a Tool to Assess Competency in Bronchoscopic Lung Volume Reduction Via Endobronchial Valve Placement

RATIONALE: Bronchoscopic lung volume reduction (BLVR) is an established treatment option for severe emphysema, improving lung function and quality of life. Despite its growing use, there are no standardized, validated tools to assess operator competency in performing BLVR, limiti...

Stretching the Applications of Simulator Rehearsal: Preparing Chemistry GTAs in Questioning Techniques

Graduate teaching assistants (GTAs) play an integral role in undergraduate STEM education. Investment in training initiatives equips GTAs with evidence-based teaching strategies. This study investigates chemistry GTAs’ responses to a questioning strategy, known as Stretch-It, dur...

Reasonable Exceptions From Unreasonable Policies: Requiring Treatment Agreements for Long‐Term Opioid Therapy and Exemptions for Cancer and Terminal Illness

Since drug overdose deaths began increasing in the United States, policy makers and the medical community have developed tools to try to address the crisis. Opioid Treatment Agreements (OTAs) are one such tool which purportedly seek to promote shared decision-making and informed...

Tramadol Co‐Administration with Oxycodone or Hydrocodone Increases Opioid Burden without Improving Postoperative Pain Control

Tramadol is frequently co-prescribed with oxycodone or hydrocodone after surgery under the assumption that its dual mechanism of action provides an opioid-sparing benefit. However, evidence supporting this practice is limited and inconsistent. We conducted a secondary analysis of...

Updated Practice Patterns for Adjuvant Treatment of Recurrent Laryngeal Papillomatosis

OBJECTIVES: Adjuvant medical treatments are used to reduce recurrence rates of recurrent respiratory papillomatosis (RRP). Prior consensus statements on initiation of adjuvants may not reflect current practices, particularly given safety data published in the interval. The object...

MERTK inhibition cooperates with immunomodulatory cyclophosphamide to induce CXCL9⁺ monocyte-macrophage programming and durable antitumor immunity in triple negative breast cancer

ABSTRACT Triple-negative breast cancer (TNBC) has high rates of recurrence despite chemotherapy and immune checkpoint blockade (ICB). Tumor-associated macrophages (TAMs) can either suppress or support anti-tumor immunity, but the mechanisms governing these states and therapeutic...

The Technology Dependence Index (TDI): Development and Validation in Neonatal and Pediatric Populations

The survival of infants and children with complex medical conditions continues to increase, underscoring the need to quantify technology dependence more effectively. Existing measures emphasize mortality risk and fail to capture the burden of ongoing technological support. To add...

The palliative care needs of adolescents and young adults with a life limiting condition: a systematic review

Adolescence and young adulthood is characterised by complex developmental and psychosocial changes. The diagnosis of a life-limiting condition adds complexity and stress to this already turbulent period of life. Provision of developmentally appropriate palliative care to this gro...

Examining smartphone-assessed executive function metrics and intrinsic resting-state functional connectivity in depression

<title>Abstract</title> Major Depressive Disorder (MDD) is a common and costly mental health condition that is often associated with deficits in executive function. Smartphone applications (“apps”) have emerged as promising methods for assessing mental health-related outcomes in...

Unleash $Q$! cohomology, localization, and interpolation in Parisi-Sourlas supersymmetry

Parisi—Sourlas supersymmetric models are known to undergo dimensional reduction; that is, their physics is captured by models in two fewer dimensions. In this work, we revisit dimensional reduction, providing new arguments and reformulating existing proofs in terms of the cohomol...

GDP-Loaded K-RasTransiently Binds to EffectorB-Raf RBD, Mirroring the Structure of the Active GTP-LoadedComplex

Abstract The Ras-Raf protein association initiates the downstream mitogen-activated protein kinase (MAPK) signaling cascade. This interaction depends on the Ras-nucleotide ligand, whereby Raf preferentially binds to the active guanosine triphosphate (GTP)-loaded state over the gu...