The Ohio State University

Clinical characteristics and outcome of a cohort of CLL patients with BTK T474 gatekeeper mutation

BTK T474 gatekeeper mutations confer resistance to both commercially approved covalent and non-covalent BTK inhibitors (BTKis) in chronic lymphocytic leukemia (CLL), yet their clinical implications remain poorly characterized. While pirtobrutinib was developed to overcome resista...

LAI-PrEP willingness among people who inject drugs in Appalachian Ohio: applying the Information-Motivation-Behavioral Skills Model

HIV remains a critical public health challenge in rural areas of the United States. Yet pre-exposure prophylaxis for HIV (PrEP) access is limited. Long-acting injectable PrEP (LAI-PrEP) could overcome barriers among people who inject drugs (PWID), but PWID’s willingness to engage...

Mental Health Ghost Networks in Commercial Insurance Plans

Importance Whether network directories in commercial insurance plans, which cover the majority of insured US residents, reliably connect patients to mental health care has only seen limited testing. Objective To assess network directory accuracy, appointment availability, wait ti...

Talking Turkey: Residential Food Waste and Thanksgiving

The act of wasting food is embedded within consumer food culture. However, little is known about how cultural events, such as the Thanksgiving holiday in the United States, relate to the amount and pattern of residential food waste. We analyze the self-reported food discards of a...

Diversification and coexistence amid widespread and persistent gene flow in Andean trees

Hybridization and introgression are increasingly recognized as important in plant evolution, yet their prevalence and consequences remain poorly understood in tropical Andean trees, where species coexist at low densities and turn over rapidly across elevation gradients. Here, we...

Cosmological Constraints from Full-scale Clustering and Galaxy–Galaxy Lensing with DESI DR1

Abstract We present constraints on cosmic structure growth from the analysis of galaxy clustering and galaxy–galaxy lensing with galaxies from the Dark Energy Spectroscopic Instrument (DESI) Data Release 1. Our analysis includes four samples drawn from the Bright Galaxy Survey (B...

Engineering ordered two-dimensional defect phases to strengthen structural alloys

Defects in crystals are usually considered to be consequences of deformation, but they can also be engineered as strengthening features. Planar defects can strengthen structural alloys but usually form only during deformation or service, limiting control over their density, stabi...

Occurrence of Norovirus and Hepatitis A Virus RNA in Agricultural Soil from Produce Farms in Ohio and Georgia

Although foodborne viruses are considered ubiquitous in the environment, studies on their presence in soil are largely lacking. In this field study, 168 agricultural soil samples were collected from farms in Georgia and Ohio over seven and eight months, respectively. A total RNA...

A scoping literature review of factors associated with burnout among student pharmacists in the United States

Objectives Burnout is an increasing challenge among student pharmacists. Individual studies have examined burnout among student pharmacists; however, faculty and college administrators lack a consolidated understanding of the educational, personal, and contextual factors associat...

Chronic Ultrasound (‘Emotional’) Stress in Mice Exacerbates Colitis Through GSK3β-Mediated Neuroimmune Dysregulation and Is Ameliorated by Probiotic Intervention

Background: Growing evidence supports a bidirectional relationship between ‘emotional’ (psychological) stress and intestinal inflammation. ‘Emotional stress’, a form of stress that is triggered by negative information and experiences of non-physical nature, is an established risk...

A second chance? Outcomes of immunotherapy retreatment after prior checkpoint inhibitor exposure in endometrial and cervical cancer

OBJECTIVE(S): As immunotherapy (IO) is increasingly utilized for treatment of endometrial cancer (EC) and cervical cancer (CC), optimal treatment strategies after IO remains poorly defined. We evaluated clinical outcomes, treatment patterns, toxicity, and survival among patients...

Crystalline-amorphous architectures modulate martensitic transformation and mechanical response in NiTi

Abstract NiTi shape memory alloys (SMAs) exhibit outstanding pseudoelasticity, yet the strongly first-order nature of their martensitic transformations (MTs) produces autocatalytic strain avalanches and large hysteresis that limit controllability and energy efficiency. Recent exp...

Near-random behavior in strategic games

Humans struggle to produce random behavior when asked to do so, leading some to suggest that our ability to randomize is attenuated (or even absent). Here, we demonstrate that the capacity for random behavior is much greater than previously acknowledged: Humans can behave in (nea...

Are Socioeconomic Status and Time in Preschool Mediators of Shared Environment Variance in Reading Ability?

While socioeconomic status (SES), time in preschool (TiP) and their interaction are related to reading ability, the results have been mixed. This study assessed whether the shared environment mediated these associations using a longitudinal behavior genetic design. Further, this...

Biofilm‐Mediated Persistence of Salmonella in Poultry Processing: A Comprehensive Review of Isolate Heterogeneity, Stress Adaptation, and Antimicrobial Resistance

ABSTRACT Salmonella enterica remains a major foodborne pathogen in poultry‐processing environments, where its persistence is largely attributed to biofilm formation on food‐contact and non‐food‐contact surfaces. Despite extensive research on Salmonella control, persistent contami...

Gradient Estimates for the Insulated Conductivity Problem with Partially Flat Inclusions

Abstract. We study the insulated conductivity problem with inclusions embedded in a bounded domain in [Formula: see text]. It was known that in the setting of strictly convex inclusions, the gradient of solutions may blow up as the distance between inclusions approaches 0. The op...

Mapping the Molecular Universe

Abstract The success of large-language-models highlighted the importance of datasets, whose quantity, quality, and diversity dictate the accuracy and creativity of artificial intelligence (AI) systems in learning and inferring. However, in scientific domains, such datasets requir...

Finite Element Analysis of Programmable Chemical Actuators

Spatiotemporal modulation of electrochemical gradients to control enzyme activity in biological systems has been achieved using programmable chemical actuators (PCAs). The electronic‐ionic coupling by polypyrrole is the operational physics foundation of PCAs. In a previous study,...

Self‐Powered, Ultra‐Sensitive InGaAs/ITO Nanowire Radial Junction Infrared Photodiode for Low Flux Imaging at Room Temperature

ABSTRACT Shortwave infrared (SWIR) photodetection and imaging are of increasing importance for many emerging applications, such as optical and quantum communications, night vision, biomedical imaging and sensing. While planar InGaAs and Ge‐based SWIR photodetectors are the curren...

The overlooked role of food and cultural dimensions in recreational fisheries

Our study examines the diversity of values within a superficially homogeneous recreational fishery and its relationship to angler diversity. We collected data on fishing preferences, behaviors, catch usage, and sociodemographics from 443 shore anglers across 10 cities in the lowe...