The Ohio State University

Care Models for the Genetic Evaluation of Dilated Cardiomyopathy at Sites of the DCM Consortium

Abstract Background Clinical genetic evaluation for patients with dilated cardiomyopathy (DCM) is minimally implemented and models of care are not defined. To understand current genetics care for DCM, a systematic needs assessment was conducted. Methods Principal Investigators (P...

Multiscale characterization of cortical signatures in positive and negative schizotypy:a worldwide ENIGMA study

Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these...

Profiles of stressful life experiences in pregnancy: a latent class approach linking early childhood adversity, intimate partner coercive control, and material hardship to adverse birth outcomes

Acute antenatal stressful life events (SLEs) during pregnancy are well-established risk factors for adverse birth outcomes. However, little is known about how distinct constellations of antenatal SLEs, shaped by early adversity, material hardship, and intimate partner coercive co...

A genomic catalog of Earth’s bacterial and archaeal symbionts

1 SUMMARY Microbial symbiosis drives the functional and phylogenomic diversification of life on Earth, yet remains underexplored due to culturing challenges. This study employed machine learning (ML) to predict symbiotic lifestyles in hundreds of thousands of microbial genomes fr...

Excessive Negative Surface Heat Flux Feedback in CMIP6 Models

Abstract Local surface heat flux feedback plays a critical role in modulating sea surface temperature (SST) variability. Here we estimate local surface heat flux feedbacks using an observational and a reanalysis data set, and outputs from 27 CMIP6 models. We find that CMIP6 model...

How precariously employed gay, bisexual, and queer immigrant and refugee men in Toronto make meaning of work, health, and wellbeing

Abstract Lesbian, gay, bisexual, transgender, and queer (LGBTQ+) people experience mental health and trauma outcomes as a result of systemic exclusion from the labour market in Canada, with less known about intersectional labour precarity for LGBTQ+ immigrants. How LGBTQ+ immigra...

Serologic Screening for Syphilis at Delivery: Mother or Infant?

Abstract Background Congenital syphilis remains a preventable cause of fetal/neonatal morbidity and mortality. The re-emergence of congenital syphilis (CS) in the U.S. has reinforced the need for optimal screening methods in mothers and infants. The Centers for Disease Control an...

Peer Talk in the Preschool Classroom: Are the Experiences of Children With Language Difficulties Distinctive?

Abstract Purpose The purpose of this study was to examine peer verbal interactions in the form of incoming and outgoing talk for children with language difficulties in preschool classrooms relative to their classmates. In addition, verbal interactions with teachers was also exami...

Using the Diffusion of Innovations Theory to Explore U.S. Horticultural Industry Stakeholders’ Adoption of Alternative Substrates

Peat is commonly used in container substrates; however, concerns about reliance on imported products, inconsistent availability, and environmental sustainability are increasing growers’ interest in transitioning to alternative soilless substrates. Several studies have explored gr...

On Increasing Sequences Formed by Points from a Random Finite Subset of a Hypercube

Consider $S$, a set of $n$ points chosen uniformly at random and independently from the unit hypercube of dimension $t>2$. Order $S$ by using the Cartesian product of the $t$ standard orders of $[0,1]$. We determine a constant $\bar x(t)

Scientific Ideals Versus Action: American Scientists’ Perspectives on Communicating With Policymakers

Despite increased scholarly attention to scientists’ role in policymaking, little is known about how scientists perceive and enact that role. We examine American scientists’ perspectives on and engagement with policymakers, recruitment into these roles, and possible influences of...

Decisions to Disclose Suicide Attempt History: A Qualitative Study

Individuals with a history of suicide attempt may face complex decisions about whether, when, and how to disclose their suicidal behavior history. However, little is known about how they navigate these decisions within family, social, and mental health care contexts. This qualita...

The Pediatric Hospitalist: A Survey of How We Are Doing

Physician well-being has important implications for clinicians, patients, and health care organizations. Burnout not only takes a human toll but is also associated with reduction in work hours, attrition, and medical errors.1 Conversely, career satisfaction is linked to improved...

The Pediatric Hospitalist: A Survey of What We Do and Where We Are Going

BACKGROUND: Pediatric hospital medicine (PHM) is undergoing structural transitions, including the discontinuation of the practice pathway to board certification and changes to pediatric resident training, decreasing inpatient exposure. In this context, understanding the compositi...

Compositional architecting by additive manufacturing enables hardenable titanium alloys

Titanium alloys (Ti-alloys) often suffer from limited strain-hardening capacity (typically <250 MPa), hindering broader adoption in demanding structural applications. This study reports a Ti-alloy with ultrahigh strain-hardening capability, enabled by a unique three-dimensional c...

Beyond benchmarking: an expert-guided consensus approach to spatially aware clustering

Spatial omics technologies have revolutionized the study of tissue architecture and cellular heterogeneity by integrating molecular profiles with spatial localization. In spatially resolved transcriptomics, delineating higher-order anatomical structures is critical for understand...

Predicting methylation-based replication timing from whole slide images

Abstract Replication timing is a costly but powerful tool for characterizing cellular mechanisms that underlie chromatin organization, cancer epigenetics, and genomic instability. Genome-wide replication timing profiles reflect the temporal order of DNA synthesis during S phase a...

Management of neonates born to mothers with reactive serologic tests for syphilis

PURPOSE OF REVIEW: The dramatic resurgence of maternal and congenital syphilis in the United States highlights the need for their optimal management as syphilis in pregnancy can result in substantial neonatal morbidity and mortality. This review summarizes current epidemiology an...

Navigating physician-scientist careers: insights from American Board of Internal Medicine Research Pathway graduates

The American Board of Internal Medicine Research Pathway (ABIM RP) is designed to train physician-scientists by shortening postgraduate clinical training and increasing research time. We surveyed ABIM RP graduates to understand career trajectories, research engagement, and barrie...

The gut microbiome in chemotherapy-induced fatigue: Exploring clinical associations and modulation via fecal microbiota transplantation in female mice

Background Fatigue is a common and debilitating side effect of chemotherapy, negatively affecting treatment adherence and survival. Chemotherapy alters gut microbiome composition, and accumulating evidence suggests that gut microbes contribute to chemotherapy-induced fatigue. Bec...