Sun Yat-sen University

Ociperlimab and tislelizumab in advanced esophageal squamous cell carcinoma (AdvanTIG-203): a phase II study

Patients with esophageal squamous cell carcinoma (ESCC) have an unmet need for new therapies that improve survival. In this phase II trial, patients received ociperlimab and tislelizumab (A) or placebo and tislelizumab (B) (NCT04732494). The primary endpoint was objective respons...

Bridging electrochemical desalination and energy storage: Coordination chemistry of organic electrode materials for capacitive deionization and aqueous batteries

Organic materials are attracting attention as tunable electrodes for capacitive deionization (CDI) and aqueous batteries, owing to their structural designability, abundant redox-active sites, and resource sustainability. This review systematically presents progress on three class...

Emerging compound air-soil heatwaves amplify global vegetation losses

Abstract Compound air-soil heatwaves—periods in which extreme air and soil temperatures co-occur—pose a growing threat to terrestrial ecosystems, yet their occurrence and impacts remain poorly understood. Here, we show that compound air-soil heatwaves have become more frequent (0...

Short-term neonatal in-hospital associations following delivery room ETI versus PPV resuscitation: a multicenter retrospective cohort study

Abstract Background Endotracheal intubation (ETI) and positive pressure ventilation (PPV) are core neonatal resuscitation interventions. Baseline clinical imbalances confound gestational-age (GA)-specific associations between ETI and in-hospital adverse events. We evaluated GA-st...

Kidney fibrosis is mediated by GARP-restricted TGF-β activation in fibroblasts

TGF-β is a central driver of kidney fibrosis, a common pathological hallmark of chronic kidney disease (CKD). Initiation of TGF-β signaling requires not only its synthesis but also the conversion of latent TGF-β to its bioactive form. However, the mechanisms governing TGF-β activ...

Integrating bioinformatics and experiments to identify neddylation-related prognostic features in prostate adenocarcinoma

Targeting neddylation represents a promising treatment strategy for prostate adenocarcinoma (PRAD). This study integrated bioinformatics and experimental approaches to identify neddylation-related prognostic genes in PRAD, with the goal of providing new insights. Public datasets...

Conceptual Interpretation and Practical Teaching Design of Ideal Work and Lost Work: Comments on Chemical Engineering Thermodynamics Textbooks

Abstract Ideal work and lost work are key contents connecting the second law of thermodynamics and engineering practice, and they pose major teaching challenges in chemical engineering thermodynamics courses. Mainstream textbooks widely use a two-step model including adiabatic re...

Y and Zn co-doped Ba(Fe,Zr)O3−δ perovskite: A cobalt-free oxygen electrode material for the high-stable proton ceramic electrochemical cells

Developing active and durable oxygen electrodes for both oxygen reduction and oxygen evolution reactions at low temperatures remains a major challenge for proton ceramic electrochemical cells (PCECs). Herein, a cobalt-free Y and Zn co-doped Ba(Fe,Zr)O 3−δ perovskite (BFZYZ) is de...

Targeted NAD + Metabolic Reprogramming Enables Functional Endometrial Regeneration and Fertility Restoration in Intrauterine Adhesions

ABSTRACT Regeneration of the injured endometrium requires re‐establishment of a permissive microenvironment that supports coordinated epithelial renewal, angiogenesis, and matrix remodeling. However, this regenerative transition remains incomplete in intrauterine adhesions, sugge...

Litui and the Logical System of Qionglixue

Qionglixue (穷理学) is the only known text from the late Ming and early Qing periods that directly translates and introduces content related to logical reasoning. The term litui (‘理推’) is the key to understanding and interpreting Qionglixue, corresponding to Latin terms Syllogi...

Additive‐Induced Low‐Coordination Solvation and Interphase Regulation for Stable Zn Anodes in Ester‐Based Calcium Electrolytes

ABSTRACT Ester electrolytes are promising for calcium batteries; however, severe interfacial instability and sluggish redox kinetics limit anodes’ operating current density to the sub‐milliampere range, severely restricting their practical application. Herein, a phenyl iodine bis...

Achieve Medium‐Range SST Forecast by Rolling 1‐Day Deep Learning

Abstract Deep learning has revolutionized short‐term Sea Surface Temperature (SST) forecasting, but often struggles with cumulative error propagation and operational complexity in medium‐range predictions. To achieve lightweight and temporally continuous SST forecast, this study...

Coupling Mechanism and Driving Paths of the Spatial Differentiation of Tourism Attractions from the Perspective of Tourist Perception—A Case Study of Xinjiang, China

As the culture and tourism industry moves toward high-quality development, tourist perception has become a core dimension for measuring that quality. Most existing work on tourism spatial differentiation still looks at the supply side, and describes the pattern of tourism attract...

An interpretable multi-scale deep learning framework for dam displacement prediction and automated early warning of structural health monitoring

Accurate prediction of displacement and early warning are fundamental to dam structural health monitoring (SHM). Hydrostatic, thermal, and aging-related environmental drivers affect dam displacements at different response rates, leading to heterogeneous hysteresis effects. Existi...

High-precision temperature-strain composite sensing based on a single resonator-type surface acoustic wave sensor using machine learning algorithms

Surface acoustic wave (SAW) sensors are extensively employed for temperature/strain measurement. However, precise temperature/strain sensing remains challenging under complex conditions involving simultaneous mechanical strains and temperature fluctuations, due to the inherent cr...

Circumferential pulmonary vein isolation (CPVI) with adjunctive linear ablation vs. CPVI alone for long-standing persistent atrial fibrillation (SINUS): study protocol for a prospective, multi-center, randomized controlled trial

Previous studies have shown that circumferential pulmonary vein isolation (CPVI) alone has a relatively lower success rate for long-standing persistent atrial fibrillation (LSPAF). This study aims to compare the efficacy and safety between CPVI combined with modified linear ablat...

Digital echoes of death and dying distress among family members of intensive care unit patients: A qualitative study

Objectives To explore how ICU family members experience and articulate death and dying distress through social media narratives. Methods This study employed a qualitative design informed by the socioecological model and a constructivist epistemological perspective. Data were draw...

The NSDHL/c-Myc/PKM2 Axis Drives Glycolytic Reprogramming and Tumor Growth in Multiple Myeloma

Multiple myeloma (MM) remains largely incurable because of its complex biology and frequent disease relapse. Metabolic reprogramming is increasingly recognized as a critical contributor to MM progression. NAD (P)-dependent steroid dehydrogenase-like protein (NSDHL) has been highl...

Multisystem involvement in extramedullary plasmacytoma: diagnostic challenges and clinical implications—a case report

Extramedullary plasmacytoma (EMP) represents 3–5% of plasma cell tumors and is commonly found in the head and neck region, upper respiratory tract, and gastrointestinal tract. Cardiac and primary lung parenchymal involvement are extremely rare. This case report describes an unusu...

Donor‐Site Outcomes of the Superficial Circumflex Iliac Artery Perforator Flap Versus Radial Forearm Flap in Unilateral Tongue Reconstruction: A Propensity Score Matching Analysis

ABSTRACT Background We compared the superficial circumflex iliac artery perforator (SCIP) flap with the radial forearm flap (RFF) to identify limitations restricting its widespread use. Methods We retrospectively evaluated unilateral tongue reconstruction using propensity score m...