Sun Yat-sen University

Characteristics, treatment patterns, and outcomes of patients with transthyretin amyloidosis: a large-scale, observational, retrospective study in China (OverTTuRe China)

Abstract Background Evidence remains limited on disease journey for transthyretin (ATTR) amyloidosis in China. This study aims to analyse China data from OverTTuRe, an observational, retrospective, multi-country cohort study. Methods Data were extracted from medical records (2013...

Multisystem involvement in extramedullary plasmacytoma: diagnostic challenges and clinical implications—a case report

Extramedullary plasmacytoma (EMP) represents 3–5% of plasma cell tumors and is commonly found in the head and neck region, upper respiratory tract, and gastrointestinal tract. Cardiac and primary lung parenchymal involvement are extremely rare. This case report describes an unusu...

Periodontitis and adverse outcomes in atrial fibrillation: prospective evidence from the UK Biobank

Abstract Background Periodontitis (PD), a prevalent chronic inflammatory disease, has been implicated in the pathogenesis of various cardiovascular conditions. Although prior evidence suggests an association between PD and incident atrial fibrillation (AF), its influence on the c...

An assessment of blended learning of Stomatology for non-stomatology medical students

Abstract Introduction and aims The COVID-19 pandemic accelerated the adoption of blended learning in medical education, highlighting its potential to address challenges in traditional pedagogy. This study evaluates the effectiveness of blended learning for non-dental medical stud...

The dawn of RAS-targeted therapy: a landmark breakthrough of daraxonrasib in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies. More than 80% of patients are diagnosed at an advanced stage, and the 5‑year survival rate remains approximately 13% [ 1 , 2 ]. For patients with metastatic PDAC (mPDAC), first-line chemotherapy...

Holocene summer and winter temperature trends and excursions in East-Central Europe from Carpathian pollen records

This study reconstructs summer and winter temperatures for East-Central Europe (ECE) over the last 12 ka using pollen records from five mid-altitude sites in the Carpathian Mountains. Seasonal reconstructions were combined into composite records and statistically evaluated to ide...

scTransMIL bridges patient-level disease states and single-cell transcriptomics for cancer screening and heterogeneity inference

Single-cell sequencing offers profound insights into tumor complexity. However, reliably linking individual cellular profiles to overall sample-level phenotypes remains computationally challenging, particularly when cell-specific annotations are absent. This disconnect limits the...

Safety and satisfaction of voluntary medical male circumcision among men who have sex with men in China

PURPOSE: To investigate the safety and satisfaction of circumcision among men who have sex with men (MSM), as voluntary male medical circumcision (VMMC) may be an innovative and acceptable tool for HIV prevention among this population in the future. METHODS: Participants who volu...

Library strategies differentially shape microbial, functional, and host signals in clinical metagenomic sequencing

Metagenomic next-generation sequencing (mNGS) is increasingly used in infectious disease diagnostics, yet how library preparation shapes the microbial, functional, and host signals recovered from clinical samples remains poorly defined. Here, we performed a within-sample parallel...

Site-Selective Fe Incorporation in Layered Polar α-In2Se3: Crystal-Chemical Control of Localized Spin States and Ferroic Responses

Abstract Site-selective transition-metal incorporation provides a crystal-chemical route for tuning local bonding, spin states, and ferroic responses in layered inorganic chalcogenides. Here, Fe-incorporated α-In2Se3 is investigated to clarify how Fe site preference and spatial d...

UA-30 ameliorates motor deficits through RalA-mediated mitophagy in ALS mice

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, skeletal muscle atrophy, paralysis, and eventually death. Mitochondrial dysfunction plays a pivotal role in ALS pathogenesis, although the precise pathogenic mechani...

HyperLayout: A decoupled and planning-oriented framework for parcel-level building layout generation

Urban development is increasingly shifting from outward expansion toward the renewal and optimization of existing urban areas. This transition has created a growing demand for building layout generation methods that can satisfy complex planning requirements while maintaining soun...

Mean apparent propagator MRI of distributed brain microstructure in anxiety-related heterogeneity among children with autism spectrum disorder: associations with thyroid hormones and trace elements

Anxiety-related symptoms contribute substantially to clinical variability in autism spectrum disorder (ASD), but the extent to which peripheral endocrine and trace-element measures map onto brain microstructure remains insufficiently defined. We investigated whether thyroid-relat...

A Cover-based Enhanced Direct Search Approach for Contact Detection of Convex Polyhedral Blocks and Its Application with 3D DDA

In implicit numerical simulation of block systems, the establishment of complete inequality constraints and the accurate enforcement of contact constraints are fundamental issues. However, the conventional direct search (DS) method is usually based on a local type identification...

Deubiquitinase USP48 Promotes Gastric Cancer Peritoneal Metastasis by Stabilizing S100A9 to Drive Neutrophil Extracellular Traps Formation

ABSTRACT Peritoneal metastasis (PM) represents the primary cause of death in patients with advanced gastric cancer (GC), yet its underlying mechanisms remain poorly understood. Neutrophil extracellular traps (NETs) have emerged as key mediators of tumor progression, but how cance...

A method for optimizing catalyst preparation conditions based on machine learning and genetic algorithm

ABSTRACT Multiphase catalytic oxidation is effective for volatile organic compound (VOC) treatment, but traditional catalyst optimization suffers from inefficiency and local optima. This work proposes an integrated strategy for Mn-Ca/γ-Al 2 O 3 catalysts that targets xylene break...

Surface Plasmon Polaritons Enable Reaction‐Specific Energy Transduction for Molecular Ionization and Isomer Discrimination

ABSTRACT Efficient and controllable conversion of optical energy into chemical energy at interfaces remains a fundamental challenge in photochemistry and catalysis. Here we show that surface plasmon polaritons (SPPs) enable reaction‐specific energy transduction for molecular ioni...

Structural and Biochemical Analysis of Human Schlafen5 Reveals the Molecular Basis of Its Anti-Tumor Function

Background: Schlafen5 (SLFN5) is an IFN-inducible member of the SLFN protein family involved in immune regulation, viral inhibition and tumor control. Recently, SLFN5 was suggested to inhibit the invasion of many kinds of malignant cells, and its expression positively correlates...

Intranasal delivery of BDNF-enriched small extracellular vesicles ameliorates cognitive impairment and Alzheimer’s disease-like pathology in APP/PS1 mice

Alzheimer’s disease (AD), the leading cause of dementia, still lacks broadly effective disease-modifying therapies. Here, we engineered brain-derived neurotrophic factor (BDNF)-enriched small extracellular vesicles (BDNF-sEVs) from human induced pluripotent stem cell-derived mese...

Discordant Interleukin-27 (IL-27) Subunit Transcription in Human Sepsis Exposes a Molecular-Attribution Gap

Background/Objectives: Interleukin-27 (IL-27) is an obligate EBI3–p28 heterodimer, yet sepsis studies commonly measure and target the axis as a single entity. We tested whether both subunit transcripts are coordinately induced in septic monocytes and whether the axis has function...