Sun Yat-sen University

A clinical scoring system for the early identification of superinfections in patients with severe fever with thrombocytopenia syndrome: An ambispective multicentre cohort study

Background Superinfection is a major contributor to mortality in patients with severe fever with thrombocytopenia syndrome (SFTS). However, early identification remains challenging because detection of the pathogen causing the superinfection is often delayed. Objective This study...

Human testis-specific TTRP regulates circadian clock as an evolutionarily young natural antisense transcript of PER2

The circadian clock orchestrates a variety of physiological and behavioral processes, endowing the ability to adapt to the cycling environment. Here, we report the identification of TTRP, a TDP-43 pseudogene that emerged in higher Hominoidea species ~8.6 Mya. TTRP is a human test...

A Novel Technique of Traction Pre‐Bladder Suturing in Single‐Position Robot‐Assisted Nephroureterectomy: Simplifying the Management of the Intramural Ureter

OBJECTIVE: To evaluate the feasibility and preliminary perioperative outcomes of a traction pre-bladder suturing technique for managing the intramural ureter during single-position robot-assisted laparoscopic nephroureterectomy (RALNU) in patients with early-stage upper tract uro...

Revision and phylogeny of the genus Loxoneptera Hampson, 1896 (Lepidoptera, Crambidae, Pyraustinae), based on morphology and molecular data

species.

Synthetic nanoplatforms for multiscale imaging in living organisms

Abstract The rapid advancements in nanotechnology have promoted transformative breakthroughs in biomedical imaging, with global research in this field exhibiting exponential growth and numerous cutting-edge achievements widely reported. This review systematically summarizes the e...

Integrative multi-omics profiling of insomnia-related molecular features reveals microbiome, immune, and therapy-relevant heterogeneity in colorectal cancer

Emerging evidence implicates insomnia as a potential risk factor in carcinogenesis, potentially involving systemic inflammation, circadian disruption, and microbiome alterations. However, the molecular associations linking insomnia-related features to colorectal cancer (CRC), par...

AR/PARP Dual‐Targeting Bioactive Photosensitizer for Photo‐Immunotherapy of Prostate Cancer

Prostate cancer poses a severe threat to men's health worldwide, and conventional therapeutic modalities are associated with various limitations. Photodynamic therapy (PDT) offers distinctive advantages such as minimal invasiveness, mild side effects and repeatable treatment. How...

Bis-Nitrene Prevails: Ligand-Controlled Divergence from the Conventional Mononitrene Pathway in Dirhodium Catalysis

Abstract Dirhodium paddlewheel complexes are widely used in C–H amination, yet whether bis-nitrene intermediates participate in catalysis remains an open question. Through systematic DFT calculations at the M06L/dgdzvp/SMD level, we show that both axial and bridging ligands exert...

Disordered eating attitudes in hospitalized schizophrenia patients of Guangdong, China: prevalence, associated factors, and the exploratory mediating role of insight in the depression-eating attitude link

This study aimed to examine disordered eating attitudes and their associated factors among hospitalized patients with schizophrenia. The primary objective was to identify sociodemographic, clinical, and psychological factors associated with eating attitudes. The secondary objecti...

Self-Sustaining Ce(IV)/Ce(III) Cycle for Spontaneous Surface Hydroxyl Radical Generation

Abstract Advanced oxidation processes are indispensable for water remediation yet face a fundamental activity–selectivity trade-off, where reactive species are competitively quenched by complex aqueous matrices. While surface-confined chemistry, specifically utilizing surface-ads...

High tryptophan 2,3-dioxygenase expression promotes lenvatinib resistance in hepatocellular carcinoma

Background Lenvatinib (LEN) is a key first-line therapy for advanced hepatocellular carcinoma (HCC), but intrinsic and acquired resistance limits its long-term efficacy. We aimed to identify novel mechanisms underlying LEN resistance and to explore clinically relevant biomarkers...

Ethical tensions in AI-mediated clinical communication: a mixed-methods study of nursing students’ perspectives

The increasing use of artificial intelligence (AI), particularly large language models (LLMs), is reshaping clinical communication by influencing how patients access, interpret, and act upon clinical information. Recent conceptual work has suggested that AI-mediated communication...

Non-coding RNA 7SK drives tumor resistance by coupling local oncogenic activation with global transcriptional repression

The conserved non-coding RNA 7SK is a well-established global transcriptional repressor, yet its context-specific functions in cancer and therapy resistance remain paradoxical. Here, we resolve this paradox by uncovering a dual-axis mechanism through which 7SK drives colorectal c...

HNRNPK Lactylation Amplifies Inflammation and Exacerbates Myocardial Ischemia/Reperfusion Injury by Regulating Jag2 Splicing

BACKGROUND: Myocardial ischemia/reperfusion injury triggers profound metabolic reprogramming and lactate accumulation. However, how this metabolic stress regulates inflammatory gene expression remains poorly understood. We hypothesized that lactylation, a lactate-derived posttran...

Multimodal automated diagnosis of lymphovascular invasion in breast cancer on contrast-enhanced MRI: ResUNet + + segmentation and transformer-based classification

Abstract Objectives To develop and evaluate an automated, multimodal Transformer model for preoperative prediction of lymphovascular invasion (LVI) in invasive breast cancer using contrast-enhanced MRI. Materials and Methods A retrospective study analyzed 288 patients with pathol...

Mixed-Connectivity GeS4 Framework for Wavelength-Dependent Linear Dichroism in Layered GeS2

Abstract Polyhedral connectivity offers a crystal-chemical route for understanding anisotropic properties in low-symmetry solids. Here, layered monoclinic GeS2 is investigated as a mixed-connectivity tetrahedral system composed of corner-sharing Ge−S−Ge bridges and edge-sharing G...

Exploitation discouragement: gender differences in entrepreneurial opportunity identification and exploitation intention

Purpose This study aims to examine whether gender dynamics vary across two distinct stages of entrepreneurial decision-making: opportunity identification and exploitation intention. Given the masculine stereotype of entrepreneurship and the socially evaluative nature of the explo...

An AI-driven reconstruction of global surface temperature with emphasis on refining the Antarctic record

Abstract. Accurate estimates of long-term surface temperature (ST) changes are fundamental not only for assessing observed warming, but also for improving the reliability of future climate projections. However, substantial missing information in global ST datasets, remains a majo...

PTTG1-driven self-amplifying loop with SP1 and ENO1 promotes IRF4-mediated myeloma progression and bone destruction

Abstract Multiple myeloma (MM) is a neoplastic disorder of plasma cells within the hematopoietic system and is characterized by osteolytic lesions. Despite significant advances, the molecular underpinnings of myeloma and its associated bone pathologies remain elusive, and there i...

Construction-Land Expansion and Economic Intensification Shape Land-Use Carbon Emissions in the Yellow River Basin Provinces

Land-use change affects regional carbon accounting through ecological conversion and the concentration of energy-intensive economic activity. We combined 30 m China Land Cover Dataset maps for 2010, 2015, 2020, and 2025 with provincial socioeconomic and energy statistics to quant...