Shanghai Jiao Tong University

Exploring the hydrogen abstraction pathway in HOM formation from α -pinene photooxidation systems under varying NO conditions

Abstract. Highly oxygenated organic molecules (HOM) are formed via autoxidation during ⚫OH-initiated oxidation of α-pinene. We investigated the relative contributions of OH-addition and hydrogen (H)-abstraction to HOM formation from α-pinene photooxidation under varying nitrogen...

Systematic pathway engineering of Escherichia coli for enhanced 3’-sialyllactose production

3’-Sialyllactose (3’-SL), the simplest sialylated human milk oligosaccharide (HMO), is widely incorporated into infant formula due to its roles in shaping the gut microbiota, inhibiting pathogen adhesion, and supporting neurodevelopment. In this study, we developed an efficient m...

From policy intent to equitable reach: a qualitative study of the hybrid community-based rehabilitation service in China

Community-based rehabilitation (CBR) is promoted to improve rehabilitation access and social participation for persons with disabilities. In China, Self-Help and Peer Support for Persons with Disabilities (SHPSPD) service is the hybrid CBR service intended to complement clinical...

Technologies for Natural‐Synthetic Polymer Hybrids: Synergistic Biointerface Engineering From Fabrication to Devices

ABSTRACT This review summarizes natural and synthetic polymer hybrid materials for biointerface engineering. Natural polymers like chitosan, collagen, and hyaluronic acid (HA) provide biocompatibility and bioactivity but lack mechanical strength, whereas synthetic polymers such a...

Kinetic-Gated Signal Transduction Decouples Binding Affinity in a Dual-Pocket Riboswitch RNA

Abstract RNA has emerged beyond its traditional biological role to become a premier biorecognition element in biosensor design. While single-target RNA sensors demonstrate high specificity, multi-pocket variants, such as the tetrahydrofolate (THF) riboswitch, enable complex signa...

A divided nation, divided views? How South Koreans’ political and social orientations shape their view of North Korea?

This study investigates how South Koreans’ political and social orientations shape their perceptions of North Korea and North Korean defectors. Analyzing nationally representative survey data (N = 8251) from the 2024 Social Integration Survey, we employ ordinary least squares reg...

Noninvasive Detection of MASH and Fibrotic Burden Using Ultrasound‐Derived LIID and LSM in MASLD: A Multicenter Study

ABSTRACT Background and Aims Metabolic dysfunction‐associated steatohepatitis (MASH), the progressive form of metabolic dysfunction‐associated steatotic liver disease (MASLD), is associated with adverse hepatic and cardiometabolic outcomes. The study aimed to validate a novel qua...

Macrophage-derived IL-1β drives endothelial-mesenchymal transition in diabetes mellitus erectile dysfunction

Diabetes mellitus erectile dysfunction (DMED) is frequently accompanied by corpus cavernosum (CC) fibrosis and endothelial dysfunction; however, the cellular drivers and molecular mechanisms underlying these pathological changes remain incompletely understood. Endothelial-to-mese...

Real-world evidence of self-managed weight loss enhancing skeletal muscle rate in individuals with overweight/obesity via mHealth app

Weight loss is essential for obesity management but may be compromised by skeletal muscle loss. This study evaluated the increase in skeletal muscle rate (SMR) and fat loss among individuals with overweight/obesity who achieved weight loss through self-management using a mobile h...

CELLServe: An SLO-Aware and Cost Efficient LLMs Serving System for Serverless Computing Environments

Large Language Models (LLMs) have enabled diverse AI applications. However, LLMs inference impose unprecedented computational and memory overhead, creating an inherent trade-off between latency Service Level Objectives (SLOs) and resource constraints. Serverless computing, with o...

Deformable and transformable nitinol alloys enable enhanced strain hardening in aluminum

Secondary rigid fillers reinforce the metals, yet usually at the cost of strain localization and reduced plasticity/toughness. Nitinol (NiTi) alloy, as a representative of shape memory materials, exhibits reversible phase transformation ability and considerable deformability upon...

Architecting optimized heterostructure for exceptional strength-ductility synergy in Mg-Gd-Y-Zn-Mn alloy

Achieving a superior combination of strength and ductility in magnesium (Mg) alloys remains challenging. Heterogeneous microstructures have been demonstrated as an effective strategy to overcome this dilemma. In this study, a remarkable strength-ductility synergy is sustained in...

AnEnergy-Sustainable and Oxidative-Tolerant Nanofactoryof Therapeutic Proteins for Long-Acting Therapy of Inflammatory BowelDisease

Abstract The ability to continuously generate bioactive therapeutics at the diseased site is an appealing and crucial advantage for the treatment of chronic relapsing diseases such as inflammatory bowel disease (IBD). Current in situ therapeutic factory strategies mainly rely on...

Xtream: A Production-Level VM Cross-Cloud Disk Migration System with Stripe-Oriented Prefetching

Virtual machine (VM) cross-cloud migration refers to the transfer of VMs between different cloud environments, enabling users to deploy their business with greater flexibility. However, VM cross-cloud migration faces many challenges in production due to the high latency and limit...

Wintertime organic carbon export provides a potential food source for zooplankton in the High Arctic

Abstract Pulsed particulate organic carbon export plays a vital role in sustaining Arctic marine ecosystems and the biological pump. Wintertime particulate organic carbon export in ice-covered Arctic waters is generally considered negligible due to light-limited local primary pro...

AI-Assisted Viable Digital Array for Rapid Quantification of Bacteria in Pediatric Urinary Tract Infections

Abstract Urinary tract infections (UTIs) are among the most common bacterial infections in neonates and infants, and delayed diagnosis can lead to severe complications. Rapid, quantitative detection of viable bacteria at the point of care remains a critical unmet need. Here, we p...

Advancing Energy Efficiency in Smart Windows via Dual‐Responsive Electro‐Thermochromism

ABSTRACT Implementing dynamic smart windows is imperative toward the construction of net‐zero buildings. However, the prevailing ion (de‐)embedding‐based electrochromic (EC) or thermosensitive hydrogel‐based thermochromic (TC) windows fail to achieve large optical modulation acro...

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

ABSTRACT Diabetic foot ulcers are a major complication of diabetes characterized by persistent inflammation and impaired tissue repair, in part driven by aberrant activation of the cGAS‐STING innate immune pathway. Precision immunomodulation in the protease‐rich wound microenviro...

Bioinspired Large-AreaPolymeric Cucurbituril Monolayerswith Ultrahigh-Density Nanopores Enabling Reversible Charge-Gatingof Ion Transport via Host–Guest Recognition

Abstract Achieving precise control over ion and molecular transport under subnanometer confinement, especially beyond passive sieving, remains challenging in nanofluidics and membrane science. Here, we present a bioinspired strategy that enables the formation of subnanometer chan...

An N-acetylated daropeptide modulates nematode development

The symbiotic bacterium Photorhabdus is a rich source of bioactive secondary metabolites that mediate tripartite interactions with nematodes and insect hosts. However, natural products of ribosomal origin remain largely underexplored within this ecological niche. Here, we report...