Shanghai Jiao Tong University

Research on multimodal dense small object detection algorithms guided by cross-modal information

To address the challenges of modality heterogeneity, scale inconsistency, and background interference in dense small object detection under multimodal conditions, this paper proposes a novel detection framework based on cross-modality guidance and hierarchical scale refinement. B...

Exploration of Metabolic Alterations in Methylmalonic Acidemia across Distinct Genetic Backgrounds

Abstract Methylmalonic acidemia (MMA) is a rare recessively inherited disorder mainly caused by variants in the MMUT and MMACHC genes, leading to the accumulation of methylmalonic acid. The pathophysiological mechanisms of MMA remain poorly understood, and treatments are symptoma...

ARID1A Mediates ROS-Induced Osteoclast Activation in TMJ Osteoarthritis

Excessive osteoclast activation drives rapid subchondral bone destruction, serving as a critical early-stage event precipitating temporomandibular joint osteoarthritis (TMJ-OA). Although epigenetic remodeling is widely recognized as an important interface between pathological env...

Black Soldier Fly Gut Microbiota as a Green Alternative to Chemical Fungicides: Broad-Spectrum Biocontrol and Implications for Reducing Fungicide Environmental Loading

Abstract Plant diseases cause 20%–40% of global crop losses, a problem traditionally managed by chemical fungicides whose extensive use leads to widespread environmental contamination and potential human health risks. This underscores an urgent need for sustainable, low-environme...

Hierarchical Hybrid Assembly: Programming Structural Complexity in Crystalline Materials

Abstract The design of crystalline materials has evolved from the construction of periodic frameworks toward increasingly complex architectures featuring ordered heterogeneity and emergent functions. Despite substantial progress in hybrid crystalline materials, a general framewor...

Effect of Photobiomodulation‑Based LED on Myopia Control in Children: An Exploratory Randomized Clinical Trial

Laser-based repeated low-level red-light (RLRL) therapy may slow myopia progression, but evidence for lower-intensity noncoherent photobiomodulation-based light-emitting diode (PBM-LED) therapy remains limited. We evaluated its short-term efficacy and safety in children with myop...

Spatial transcriptional signatures linked to brain activity patterns in MECP2 transgenic monkeys and human autism spectrum disorder

Imaging transcriptomics studies in autism spectrum disorder (ASD) have identified relevant biological pathways, yet the specific laminar molecular signatures associated with functional abnormalities remain largely unexplored. We integrated resting-state fMRI (rs-fMRI) data from m...

Guided differential dilated convolutional network for fault diagnosis of hydraulic manipulators

Fault diagnosis for hydraulic manipulators plays a crucial role in ensuring operational safety but still faces challenges in fault localization. To address this issue, a guided differential dilated convolutional network (GDDCN) is proposed in this study. First, a novel interferen...

Cu-deficient Cu–Fe Prussian blue analogues enable phosphate/GSH-coupled redox remodeling for catalytic/sonodynamic cancer therapy

Cu–Fe Prussian blue analogues (PBAs) are promising platforms for nanocatalytic medicine owing to their redox-active Cu/Fe centers and open metal–cyano coordination frameworks. Nevertheless, the influence of Cu deficiency on their enzyme-mimetic catalytic behavior in tumor-relevan...

Insight into three -dimensional (3D) printing and bioprinting in oncology and neurology: Perspectives on diagnosis and therapy

Three-dimensional (3D) printing has become a life-changing technology in biomedical sciences, offers new possibilities for personalized and precise therapeutic interventions. In anticancer research, 3D printing provides a unique platform for tailored therapies. Enabling the fabri...

Navigating the Digital Leisure Landscape: The Relationship between Online Gaming, Short Video Consumption, and Marital Satisfaction

Amidst evolving digital leisure habits, research on their impact on marital satisfaction remains limited. This study investigates the mechanisms linking digital leisure (online gaming and short video consumption) to marital satisfaction using a representative sample of 396 Chines...

The Negative Impact of Digital Overload on Civil Servants’ Work Outcomes: The Moderating Role of High-Performance Human Resource Management Practices

As digitalization accelerates, digital overload is placing increasing pressure on civil servants. This study draws on the Job Demands–Resources model and analyzes 3 waves of survey data from 653 civil servants, along with a scenario-based experiment involving 138 participants. Fi...

A copula-based poisson-mixed multinomial logit model for joint analysis of vessel incident types and fatality counts: Evidence of tail dependence from commercial fishing data

Commercial fishing remains one of the most hazardous occupations worldwide, with high fatality rates and complex incident dynamics, making the joint understanding of incident type and fatality frequency critically important. This study addresses the limitation of conventional app...

A Bayesian refinement method incorporating geometric prior and LLM-guided hyperprior for measurement-grade overhang analysis in X-ray electrode inspection

Accurate electrode instance identification from X-ray images is essential for reliable overhang analysis in lithium-ion battery electrode inspection. However, industrial X-ray radiographs often exhibit blurred edges, contrast attenuation, and structural occlusions caused by layer...

Colloidal Synthesis of Monodisperse High-Entropy Rare-Earth Oxide Nanoplatelets

Abstract High-entropy rare-earth oxides (HE-REOs) offer a broad compositional space for tuning defect chemistry, lattice distortion, and local atomic environments, yet their controlled synthesis as monodisperse and structurally well-defined nanostructures remains challenging. Her...

Integrated machine learning and clinical validation identify COL21A1 as a potential biomarker for sarcopenia

Sarcopenia is a progressive skeletal muscle disorder characterized by loss of mass, strength, and function. However, reliable molecular biomarkers for early detection remain limited. This study aimed to identify and validate potential biomarkers for sarcopenia through a combinati...

Effects of cryo-parameters and retrieval methods on specimen acquisition and quality for ultrathin cryoprobe transbronchial cryobiopsy in porcine models

Ultrathin cryoprobes enable direct retraction through the working channel during transbronchial cryobiopsy. However, key factors of biopsy performance remain insufficiently characterized. This study evaluates cryo-parameters and retrieval methods across different working channels...

Adjunctive n-3 PUFA supplementation improves niacin skin flush response and shows biomarker-stratified signals in schizophrenia

BACKGROUND: Findings regarding the efficacy of n-3 polyunsaturated fatty acid (PUFA) supplementation as an adjunct treatment for schizophrenia (SZ) have been inconsistent. This study investigated whether n-3 PUFA supplementation was associated with changes in niacin skin flush re...

Factors influencing family disease management and disease management difficulties in children with congenital gastrointestinal malformations: The roles of caregiver burden, social support, and family function

BACKGROUND: Children with congenital gastrointestinal malformations often have complex conditions that require long-term treatment and care, which can negatively impact their physical and mental well-being as well as their families, who play a crucial role throughout their treatm...

Validity of the twin-force analogy in Couette flows

This study combines linear stability analysis (LSA) and direct numerical simulations (DNS) to investigate the coupling mechanisms of rotation, stratification and shear in two flow geometries: spanwise rotating stratified plane Couette flow (between two infinite parallel plates) a...