Shanghai Jiao Tong University

AI-driven drug design for head and neck squamous cell carcinoma using GNN and structure-based simulations

Head and neck squamous cell carcinoma (HNSCC) remains a major global health burden with limited targeted therapeutic options. Here we present an integrated artificial intelligence (AI)-driven drug discovery framework combining graph neural networks (GAT, GCN, AttentiveFP and GIN)...

Harnessing Diversity: Majority‐Group Acculturation Predicts Creativity and Flourishing Over Time

ABSTRACT Creativity and flourishing are core aims of higher education (HE) institutions and government initiatives globally. Large‐scale projects have linked creativity and flourishing with cultural diversity, yet their associations with majority‐group acculturation (i.e., how me...

Establishing a single-cell RNA sequencing workflow using EUS-guided fine-needle aspiration for pancreatic ductal adenocarcinoma

Background and Objectives: No unified consensus exists regarding standardized protocols for single-cell RNA sequencing (scRNA-seq) analysis of samples obtained via EUS-guided fine-needle aspiration (EUS-FNA). This study aimed to evaluate the feasibility of applying scRNA-seq to E...

A numerical investigation on ultimate strength of marine sandwich composites under combined biaxial compression and lateral pressure

With the development of large-scale and light-weight ships, sandwich composites are increasingly used in hull structures because of their advantages of light weight, excellent mechanical properties, and corrosion resistance. Due to the synergistic effect among materials, sandwich...

Narrating for whom? Negotiating proper distance in sponsored narratives of therapeutic experiences in the platformized influencer economy

As online therapy services increasingly rely on social media platforms and influencers for advertising, this study interrogates influencers’ sponsored narratives of therapeutic experience. Through an illustrative case of Glowe , a leading Chinese counseling platform whose marketi...

Does Test Duration Matter? Comparing 1‐s and 5‐s Isometric Mid‐Thigh Pull Protocols for Performance Diagnostics in Basketball Players

ABSTRACT To compare kinetic characteristics of a 1‐s isometric mid‐thigh pull (IMTP) protocol with the traditional 5‐s protocol and examine their associations with basketball‐specific performance. Twenty‐five Tier 3 male basketball players performed standardized 1‐s and 5‐s IMTP...

Collaborative optimization framework of battery charging/swapping stations for eVTOLs based on closed-loop supply chain and space-time network

Electric vertical take-off and landing (eVTOL) aircraft, by virtue of their advantages such as high efficiency, environmental friendliness, and low noise, are regarded as an effective means of alleviating urban traffic congestion. Although eVTOLs have policy support, industrial f...

A flat-band perspective on the boson peak in amorphous solids

The boson peak is a characteristic anomaly of amorphous solids broadly defined as a low-energy excess in the density of states and heat capacity compared to the textbook predictions of Debye theory. The origin of this anomaly has long been the subject of ongoing debate and remain...

Collaborative Suppression Method Based on Current Preprocessing and Active Power Decoupling for Second-Order DC Voltage Ripple in PFC Converters

This paper presents a collaborative second-order voltage ripple suppression control method for single-phase power factor correction (PFC) converters. First, the causes of second-order DC output voltage ripples are analyzed. Then a modified current preprocessing mechanism is prese...

Stabilizer ModulatedArea-Selective Growth of VerticallyAligned Carbon Nanotube Forests toward Thermal Interface Materials

Abstract Area-selective growth of vertically aligned carbon nanotube (VA-CNT) forests is critical for constructing spatially controlled thermal transport pathways in thermal interface materials. This capability is particularly important for thermal management scenarios involving...

Uncovering the microbiota-metabolite axis across levels of metabolic complication burden in Chinese adolescents with obesity

Pediatric obesity presents with diverse metabolic phenotypes, yet the gut microbiota and metabolite signatures associated with obesity-related metabolic complications remain poorly defined. Here, we applied 16S rRNA gene sequencing and untargeted fecal metabolomics to investigate...

A Bacterial–Microalgal–Manure Co-Application Ameliorates Saline-Alkali Soil and Promotes Wheat Growth

Severely saline–alkaline land degradation poses a considerable challenge to sustainable agriculture, owing to high salinity, elevated pH, and nutrient deficiency. To address this, a salt-tolerant nitrogen-fixing bacterium (Bacillus sp.) and a microalga (Chlorella pyrenoidosa) wer...

Stroke survivors’ health priorities and targeted interventions in home-based post-discharge rehabilitation

<title>Abstract</title> Background This study aimed to describe health problems of the stroke survivors and the corresponding nursing interventions implemented during 12-week home-based post-discharge rehabilitation. Methods This was a descriptive secondary analysis within the co...

Relative Localization of a Floating Recovery Target in an Unmanned Surface Platform-Assisted UAV–ROV Search-and-Recovery System Under High Sea States

This study addresses target-to-ROV relative localization in an unmanned surface platform-assisted UAV–ROV search-and-recovery system. Because the submerged ROV is not assumed to be visible from the air, the UAV observes the floating target and a GNSS-equipped ROV-associated surfa...

Method comparison of a ring-based PPG device and a chest-strap monitor for heart rate and heart rate variability in shooting athletes

<title>Abstract</title> Introduction: Ring-based photoplethysmography (PPG) devices are increasingly used in athlete monitoring, but evidence remains limited for precision-sport settings and finger-worn form factors. This study examined the agreement between a ring-based PPG devi...

DUSP4 promotes anti-tumor CD8+ T cell function and boosts CAR-T cell efficacy in mouse colorectal cancer

The activation and function of CD8+ T cells, which are central for anti-tumor immunity, are tightly regulated by extracellular and intracellular signaling pathways. Dual-specificity phosphatases (DUSP), including DUSP4, dephosphorylate serine/threonine and tyrosine residues of pr...

Encapsulated CsPbBr3 quantum dots with asymmetric chiral magneto-optoelectronic responses

Quantum emitters having non-trivial spin polarizations are highly demanded for chiral quantum devices and quantum photonic technologies. Here we investigate the magneto photoluminescence spectroscopy of perovskite quantum dots encapsulated in silica and report an observation of c...

Sensitive andReproducible SERS Profiling of Tumor-DerivedEVs via Uniform Microfluidic Nanobowl Arrays for Pancreatic CancerManagement

Abstract Tumor-derived extracellular vesicles (EVs) are promising liquid biopsy biomarkers, yet their clinical translation is hindered by the trade-off between enhancement and reproducibility of SERS-based detection. Here, we present a microfluidic SERS platform integrating plasm...

Digital therapeutics for mild adolescent idiopathic scoliosis: a protocol for a randomized controlled trial

Abstract Background Digital therapeutics (DTx), a new type of intervention presented in the last few years, can be used to provide patients with access to evidence-based therapeutic interventions using high-quality software programs to achieve the purpose of treating, managing, o...

Fuzuloparib in combination with apatinib versus fuzuloparib alone for recurrent ovarian cancer: a randomized, open-label, phase 2 trial

A randomized, open-label, phase 2 trial assessed fuzuloparib (a PARP inhibitor) plus apatinib (a vascular endothelial growth factor receptor [VEGFR] inhibitor) versus fuzuloparib alone in patients with recurrent ovarian cancer (ROC). Patients with ROC who had failed ≥ 2 lines of...