Shanghai Jiao Tong University

Response to the Correspondence Regarding “Cutaneous Metastasis From Papillary Thyroid Carcinoma Eight Years After Initial Surgery”

ABSTRACT We sincerely thank Dr. Sengul and colleagues for their insightful comments on our case report of skin metastasis in papillary thyroid cancer (PTC). They questioned the adequacy of local excision and suggested completion thyroidectomy to enable radioactive iodine (RAI) th...

Historical distance: affective practice in immersive heritage at the Mogao Caves, China

Heritage institutions increasingly invest in immersive experiences, yet research often treats affect as a consequence of immersion rather than a force that shapes how visitors relate to the past. In the context of conservation at the Mogao Caves, this study examines how three imm...

Ligand-Dependent Affinity but State-Dominated Efficacy in Structure-Based GPCR Pharmacology Prediction

Abstract High accuracy in structure-based prediction of G protein-coupled receptor (GPCR) efficacy may reflect the receptor state rather than ligand-specific information. We addressed these information sources using state rules, ligand-blind baselines, matched receptor-state cont...

Upadacitinib in East Asia: Translating Trial Results Into Maintenance Care

Data sharing is not applicable to this article as no new data were created or analyzed in this study.

The pro-obesity role of G3BP1 through altering adipogenic differentiation in mice via the PI3K/AKT pathway

As a growing but non-infectious epidemic, obesity is a common cause of several comorbidities. GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is a central regulator of stress‑granule assembly that has significant implications in metabolic disorders. This article ai...

“Precision planning for tissue expansion: A three-dimensional scanning-based predictive model to guide surgical timing”

Tissue expansion remains an essential reconstructive technique, yet the timing of expander removal is still largely determined by subjective clinical judgment. We developed a three-dimensional (3D) scanning-based quantitative workflow to objectively monitor expansion progress and...

From scrap to prime: Designing high-performance alloys from dirty feedstocks with machine learning

Producing alloys from recycled metals via secondary synthesis can markedly cut energy use, greenhouse-gas emissions, and dependence on scarce, strategically important elements relative to primary routes. The central obstacle is the feedstock itself: Scrap is chemically heterogene...

LLM-assisted dynamic graph reconfiguration for post-disaster compute-power collaborative resilience in energy-informatics systems

Extreme weather can jointly disrupt data-center, power-supply, and communication infrastructure, threatening the continuity of critical tasks through resource degradation and migration restrictions. Meanwhile, operating information is scattered across heterogeneous reports, alarm...

DNA-Encoded Binding Affinity Shapes Robust CTCF Occupancy Across Cellular Contexts

CCCTC-binding factor (CTCF) is an architectural protein that organizes 3D genome architecture by binding to tens of thousands of genomic loci in a typical human cell type. Although DNA-binding affinity contributes to CTCF occupancy in vivo, the principles distinguishing robust fr...

Untangling the Molecular Mechanism of SpCas9 HNH Domain Checkpoint Activation: A Gear-and-Wedge Fitting Model

Abstract The CRISPR-associated endonuclease Streptococcus pyogenes Cas9 (SpCas9) facilitates site-specific DNA cleavage, with structural transition from the checkpoint state to the catalytic conformation representing a critical activation step. This transition involves an approxi...

Girth Characterization of (3,29)-Regular Bipartite Graphs and Their Associated LDPC Codes

This paper studies a family of (3,29)-regular bipartite graphs introduced by Tanner for low-density parity-check (LDPC) codes. For a prime p≡1(mod87), the graph has 3p left vertices and 29p right vertices. In the associated LDPC code, the right vertices (there are 29p of them, ea...

Effect of geometric protrusions and depressions on critical heat flux density of the heating surface

In the “Melted Reactor Retention and External Pressure Vessel Cooling (IVR-ERVC)” strategy for nuclear power plants, the Critical Heat Flux (CHF) serves as the critical limit for ensuring pressure vessel integrity. Traditional safety assessment procedures rely on an ideal flat su...

Higher-Order Boundary Conditions for Atomistic Dislocation Simulations

Abstract. We present a higher-order boundary condition for atomistic simulations of dislocations that address the slow convergence of standard supercell methods. The method is based on a multipole expansion of the equilibrium displacement, combining continuum predictor solutions...

A shrinking target problem in homogeneous spaces of semisimple algebraic groups

In this paper, we study a shrinking target problem with target at infinity in a homogeneous space of a semisimple algebraic group from the representation-theoretic point of view. Let 𝜌 : 𝐆 → 𝐆 𝐋 ⁡ ( 𝑉 ) be an irreducible ℚ -rational representation of a connected semisimple ℚ -alg...

Global Incidence of All-Cause Dementia

Importance Global dementia incidence estimates are limited by underrepresentation of low- and middle-income countries and heterogeneous analytic methods. Due to these limitations, true understanding of the global dementia landscape remains incomplete. Objective To identify dement...

Positional Isomerism: A Molecular Switch for Substantial Modulation of Polymer Mechanics

Abstract Positional isomerism, a universal structural regulation strategy in nature, achieves precise control over biological functions through minute variations in substituent positions on a molecular backbone. Despite its extensive application in small-molecule chemistry, the s...

A trans-therapeutic signature of recovery in internet gaming disorder: From shared network reorganization to molecular underpinnings.

Background and aims: A variety of self-regulation interventions have shown efficacy in treating Internet Gaming Disorder (IGD), but their shared and unique neurobiological mechanisms remain unclear. This study aims to identify a common, trans-therapeutic neural signature of recov...

Virtual recreation of urban heritage of Jingdezhen for immersive VR display

To unify the decoupled dimensions of scientific rigor and contextual narrative in virtual heritage display, this paper uses the VR project developed for Jingdezhen’s bid for World Cultural Heritage as a case study, and establishes a workflow for the virtual recreation of urban he...

GNAZ suppresses lung adenocarcinoma progression through HUWE1-mediated KIF11 ubiquitination and modulates the response to osimertinib

Osimertinib is a standard targeted therapy for EGFR-mutant lung adenocarcinoma (LUAD), yet substantial variation in treatment response remains a clinical problem. Here, we investigated the role of GNAZ, a heterotrimeric G-protein α-subunit that remains poorly characterized in lun...

Finishing Touch via Metal Coordination: A Photoactivatable Organic Semiconducting Prodrug for Triply Synergistic Amplified Cancer Phototheranostics

ABSTRACT Photothermal therapy (PTT), photodynamic therapy (PDT), and NIR‑II fluorescence imaging are each compromised by tumor hypoxia, thermotolerance, and insufficient contrast, respectively, limiting the efficacy of integrated phototheranostics. To address these challenges, we...