Shanghai Jiao Tong University

Hepatic PDIA5 improves hyperglycaemia and insulin resistance through stabilisation of ATF6

Dysregulation of hepatic glucose production, primarily driven by aberrantly elevated gluconeogenesis, is a core pathological feature of type 2 diabetes. However, the molecular mechanisms governing this process remain incompletely understood. Protein disulfide isomerase A5 (PDIA5)...

The complete chloroplast genome dataset of Feijoa sellowiana and its basic characterization

Feijoa ( Feijoa sellowiana , syn. Acca sellowiana ) is an economically important fruit tree species in the family Myrtaceae. However, genomic resources, particularly complete chloroplast genome datasets, remain limited for this species. The generation of plastome data is essentia...

Ceria-Based Nanotherapeutics for Inflammatory Skin Disorders: From Design and Mechanisms to Advanced Delivery and Future Perspectives

Inflammatory skin diseases, including atopic dermatitis (AD), psoriasis, diabetic wounds, and photoaging, represent major public health challenges due to their high prevalence, chronic recurrence, and substantial disease burden. Current treatments, such as glucocorticoids, calcin...

Automated screening of autism via a pretrained vision-language model in naturalistic caregiver-child interactions

Early autism screening is essential for timely intervention but remains constrained by specialist dependence, costly protocols, and limited accessibility. We present Autism-CLIP, a vision-language model that automates screening from 3-min naturalistic caregiver-child interaction...

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

ABSTRACT The immunosuppressive microenvironment limits immunotherapy in triple‐negative breast cancer (TNBC). Interleukin‐15 (IL‐15) activates cytotoxic lymphocytes but is limited by rapid clearance and poor tumor retention. Here, we developed an oncolytic adenovirus encoding IL1...

Laboratory Investigation of the Effects of Asphalt Mixture Volumetric Properties on the Permeability and Durability of Open-Graded Friction Course

This study investigates the volumetric properties and performance relationships of open-graded friction course (OGFC) mixtures by examining the effects of interconnected air voids (IAVs), asphalt film thickness (FT), and the D 10 (particle size index) on permeability and durabili...

PRDM16 as a Multifaceted Pharmacological Target in Kidney Diseases: From Epigenetic Mechanisms to Therapeutic Strategies

PRDM16 is a PR domain-containing epigenetic regulator with intrinsic histone methyltransferase activity and scaffolding interactions with corepressor complexes such as CtBP1/2. Beyond its well-established roles in adipose biology, emerging evidence positions PRDM16 as a central n...

Overweight/Obesity and Hyperinsulinemia Impair Oocyte Developmental Competence via Cumulus Cell Dysfunction and Oxidative Stress-Mediated Follicular Microenvironment Remodeling

Overweight and obesity, frequently accompanied by hyperinsulinemia, are established risk factors for female infertility. Cumulus cells (CCs) are hypothesized to play a crucial role in this etiology, yet the underlying mechanisms remain largely elusive. In the current study, we in...

Toward precision psychiatry: integrating pharmacogenomics and multimodal clinical data for personalized antidepressant response prediction

Individual responses to antidepressant treatment are highly heterogeneous, resulting in prolonged trial-and-error processes that undermine clinical outcomes. Pharmacogenomics (PGx) holds substantial promise for advancing precision psychiatry by guiding personalized antidepressant...

Single-cell transcriptomics landscape decodes cardiac fibroblast heterogeneity and reveals PDK4-driven profibrotic activation during cardiac fibrosis

Cardiac fibroblasts act as a key driver of myocardial fibrosis across various heart diseases, but the recently recognized heterogeneity within fibroblast populations has hindered mechanistic understanding. This study aimed to investigate the heterogeneity of cardiac fibroblasts a...

Powering the liver toxicity assessment in the organoid era

Hepatotoxicity assessment is paramount in drug development and food safety. Traditional in vitro models suffer from insufficient physiological relevance and poor functional reproducibility. Liver organoids have rapidly emerged as three-dimensional culture models capable of recapi...

Effect of External Magnetic Field on Microstructure and Mechanical Properties of GMW2/H1000 Resistance Spot-Welded Joints

This study investigated the effect of magnet working distance on the external magnetic-field distribution, weld-nugget geometry, and mechanical response of GMW2/H1000 dissimilar steel joints produced by magnetic-field-assisted resistance spot welding (MA-RSW). Three-dimensional m...

Towards the Vision-Sound-Language-Action paradigm: The HEAR framework for sound-centric manipulation

Humans and animals use sound as a crucial cue for interacting with the physical world, as acoustic events can reveal contact, completion, hidden contents, or process state. Embodied agents should similarly benefit from auditory awareness during manipulation, yet existing Vision-L...

Adaptive Scheduling of Public Electric Vehicle Fast-Charging Stations Based on State-Aware Multi-Agent Reinforcement Learning

This paper proposes a Priority–Urgency Index (PUI) mechanism to address the multi-objective conflict problem in electric vehicle charging scheduling at public fast-charging stations. The mechanism dynamically quantifies the charging urgency of each vehicle based on remaining dwel...

An iPAS-optimized phage cocktail delivered by a skin-derived ECM hydrogel for antimicrobial-regenerative treatment of seawater immersion wounds infected with MDR E. coli

Seawater immersion (SWI) wounds are prone to multidrug-resistant (MDR) bacterial infections and impaired tissue repair, yet dual-function wound dressings that combine robust antibacterial activity with proregenerative capacity remain scarce. Through shotgun metagenomic sequencing...

Vernacular Architectural Knowledge in Historic Fortified Settlements of the Middle Qinhe River Basin

Historic fortified settlements constitute a distinctive component of the traditional settlement heritage of the Qinhe River Basin, where they historically combined defensive, residential, clan-governance, commercial, transport, and resource-use functions. Previous research has ge...

Dynamics-aware hierarchical decision–control with egocentric perception for robust navigation of underactuated uncrewed surface vehicles

Reliable navigation of underactuated uncrewed surface vehicles (USVs) in complex waters depends on the consistency between adaptive decision-making and physically executable motion under nonlinear dynamics and environmental disturbances. Existing deep reinforcement learning metho...

Research on dual coupling model for dynamic analysis of USV-assisted floating pipe docking for TSHDs

Pump-ashore floating pipe docking relies on manual connection for trailing suction hopper dredgers (TSHDs), leading to efficiency and safety bottlenecks. A docking solution involving a cabled unmanned surface vehicle (Cabled-USV) is proposed to address the complexities associated...

Electrically controllable superconducting memory effect in UTe2

Abstract Multiphase superconductors—materials that host two or more distinct superconductive phases—are exceptionally rare. Examples include heavy-fermion CeRh 2 As 2 alongside some uranium compounds such as UPt 3 and URhGe (refs. 1,2,3 ). In the multiphase p -wave superfluid 3 H...

Extremal problems about the order and size of nonhamiltonian locally linear graphs

The relation between local structure and global cycle properties is a classical topic in graph theory. A graph $G$ is locally linear if $G[N(v)]$ is a path for every $v\in V(G)$. It is locally Hamiltonian or locally traceable if every vertex neighborhood induces a Hamiltonian or...