Shanghai Jiao Tong University

From natural vesicles to intelligent carriers: the metabolic basis and biomedical applications of lemon-derived extracellular vesicles

Lemon-derived extracellular vesicles (LEVs) are a promising class of plant-based nanocarriers that have gained increasing attention for their biomedical potential. This review systematically summarizes recent advances in the isolation, characterization, composition, and therapeut...

20-year experience of biomet stock alloplastic temporomandibular joint replacement in Chinese patients after technical modifications: a single-center retrospective study.

OBJECTIVES: To evaluate the clinical and radiographic outcomes of the Biomet stock alloplastic temporomandibular joint replacement (ATJR) after seven progressive surgical modifications in Chinese patients at a single center. MATERIALS AND METHODS: Patients who underwent ATJR from...

Microenvironment-aware transcriptome reconstruction in spatial transcriptomics

Abstract Imaging-based spatial transcriptomics offers single-cell resolution but measures limited panels dominated by identity-defining genes, leaving transcriptome-wide variation unobserved. Existing approaches for predicting unmeasured genes rely mainly on shared-gene alignment...

AI4AI Survey: From Long-Horizon Agents to Recursive Self-Improvement — Definitions, Reliable Horizons, and Open Problems

Can AI improve AI? AI agents can now run experiments, modify code and training pipelines, and iteratively improve AI artifacts. Yet the literature remains fragmented across long-horizon agents, AI for AI (AI4AI), self-improvement, and recursive self-improvement, making it difficu...

UPMA: unspecified pretraining and modular adaptation for context-aware target delineation in adaptive esophageal radiotherapy

Abstract Esophageal cancer, a serious malignancy, is primarily treated with radiotherapy (RT). Accurate delineation of gross tumor volume (GTV) and clinical target volume (CTV) is essential, yet manual contouring is time-consuming and automatic methods remain challenging. Adaptiv...

Effects of Irradiance, Pressure, and Temperature on the Photodegradation of Fast Pressure-Sensitive Paints

Photodegradation limits the accuracy of fast pressure-sensitive paints (PSPs), but its dependences on irradiance and operating conditions remain insufficiently researched. Here, the photodegradation kinetics of a polymer–ceramic PSP (PC-PSP) and a mesoporous-particle PSP (MP-PSP)...

Low-Complexity Three-Layer GII Encoders Based on a Grouping Strategy

Generalized integrated interleaved (GII) codes have emerged as a compelling coding solution for distributed storage systems, as they achieve a favorable tradeoff between error-correcting capability and repair locality. Compared with conventional two-layer GII codes, three-layer G...

An interpretable learning framework for exploring superelastic degradation of NiTi shape memory alloys using multimodal data

Abstract Superelastic degradation (SED), a progressive loss of functionality in NiTi shape memory alloys under cyclic loading, remains challenging to characterize precisely, thereby constraining their engineering applications and broader adoption. In this study, an interpretable...

Metasurface‐Based Terahertz Three‐Dimensional Holography Enabled by Physics‐Informed Neural Network

ABSTRACT Artificial intelligence has revolutionized optical device design, overcoming the efficiency bottlenecks of traditional methods. For holographic metasurfaces, conventional iterative algorithms suffer from time‐consuming iterations and convergence stagnation, especially as...

Residual-stress-driven deformation of thin-walled ring gears during hobbing

Thin-walled ring gears are prone to hobbing-induced distortion because material removal redistributes body residual stress (BRS) and introduces machining-induced residual stress (MIRS). This study distinguishes BRS and MIRS and establishes a coupled finite element method (FEM) wo...

Parturition attenuates endothelial senescence to resist nitrosative stress-induced heart failure with preserved ejection fraction in mice

Abstract Background Heart failure with preserved ejection fraction (HFpEF) accounts for 50% of heart failure patients and is biased toward elderly females. Nitrosative stress-induced HFpEF animal studies fail to phenocopy this sex bias and the underlying pathological mechanisms r...

Synergistic Grain Boundary and Phonon Engineering Enables Ultrahigh Thermoelectric Performance in Mg 3 (Sb, Bi) 2 ‐Based Materials

ABSTRACT Thermoelectric Mg 3 (Sb, Bi) 2 has emerged as a rising star in virtue of its promising thermoelectric performance and abundant constituent elements. However, its practical application is hindered by challenges in synthesis and the strong coupling between electrical and t...

Sparse semi-interpretable networks for discovering nonlinear dynamics with time-varying parameters and switching structures

Data-driven equation discovery has emerged as a new focal point in nonlinear dynamics. While significant progress has been made in identifying governing equations of time-invariant dynamical systems, the existing approaches still encounter considerable obstacles when applied to s...

Invasive candidiasis in the Intensive Care unit: diagnostic stewardship, source control, and precision antifungal therapy

INTRODUCTION: Invasive candidiasis remains one of the most challenging infections in the intensive care unit (ICU) because diagnosis is complicated by nonspecific clinical manifestations, frequent colonization, altered host immunity, complex anatomical sources and unstable pharma...

Cell-inspired dual-tandem catalytic nanoreactors drive targeted hearing protection

Sensorineural hearing loss is driven by disruption of cochlear homeostasis, where dysregulated redox, ionic, and metabolic factors lead to hair cell degeneration and synaptic injury. Current strategies lack the capacity to restore the enzymatic clearance of reactive oxygen specie...

Higher eGFRdiff is associated with increased risk of rapid kidney function decline in hypertensive individuals

Abstract Background Hypertensive nephropathy is the second contributing factor to end-stage renal disease, while the relationship between the difference between estimated glomerular filtration rates (eGFRdiff) and rapid kidney function decline (RKFD) in hypertensive patients rema...

Emerging nitrogen-driven urban atmosphere control on aerosol iron dissolution for biogeochemical cycles

Iron (Fe) is a critical micronutrient regulating marine productivity and the global carbon cycle, yet its atmospheric dissolution mechanisms remain debated for biogeochemical cycle. The prevailing “iron-sulfur coupling” paradigm has traditionally explained proton-promoted dissolu...

Varifocal displays reduce the impact of the vergence-accommodation conflict on 3D pointing performance in augmented reality systems

This paper investigates whether a custom varifocal display can improve 3D pointing performance in augmented reality (AR), where the vergence-accommodation conflict (VAC) is known to impair interaction. Varifocal displays have been hypothesized to alleviate the VAC by dynamically...

Neonatal Reversible Aortic Constriction Mice Model Unlocks Distinctive Footprints of Young Heart Recovery

BACKGROUND: Left ventricular (LV) reverse remodeling has been linked to long-term prognosis and life quality of pediatric patients with LV outflow tract obstruction. However, a lack of suitable animal model limits further study of LV reverse remodeling in young hearts. This study...

Label-free ovarian cancer histopathological diagnosis using two-photon autofluorescence microscopy with a joint denoising and segmentation framework

Two-photon autofluorescence (TPAF) microscopy is a promising modality for rapid, label-free assessment of unstained tissue, but is fundamentally limited by the poor visibility of nuclei, which are one of the gold-standard cancer biomarkers, due to their negative contrast nature....