Shanghai Jiao Tong University

Herb‐Based Chiral Nanomaterials: Potential Application in Wound Healing and Nanomedicine

The remarkable progress in nanomedicine has opened new frontiers in boosting therapeutic efficacy and reducing off-target side effects. However, fabricating chiral nanomaterials remains challenging due to difficulties in sustaining chiral configuration stability. In this study, c...

Functional characterization of a pore‐forming effector TseMt from the H4 type VI secretion system of Pseudomonas aeruginosa

Abstract Pseudomonas aeruginosa is a major nosocomial pathogen in which the type VI secretion system (T6SS) contributes to interbacterial competition and virulence. While most strains encode three T6SSs, additional T6SS clusters have been identified in clinical isolates through c...

Towards density-optimal DNA storage with practical bijective coding

DNA storage is a promising solution to data explosion due to its high density and longevity. However, existing coding methods struggle to efficiently avoid error-prone sequences while retaining usable ones, leading to low density and high copy numbers. Here we show Siyuan Code, a...

Endothelial function in relation to low-level chronic residential air pollution in a general population: a cohort study

Background Given the recently updated clean-air targets, this population study assessed endothelial function at low exposure to particulate matter with an aerodynamic diameter of ≤10 µm (PM10) and ≤2.5 µm (PM2.5), nitrogen dioxide (NO2), and black carbon (BC).Methods In 453 Flemi...

A conserved small RNA-generating gene cluster undergoes sequence diversification and contributes to plant immunity

Abstract Small RNA-mediated gene silencing contributes to plant immunity. The secondary small interfering RNA (siRNA) pathway promotes defense by silencing target genes in invading fungal and oomycete pathogens. Many secondary siRNAs are derived from transcripts potentially encod...

Breaking Alzheimer's Disease Barrier: The Role of Xanthoceras sorbifolia Bunge Oil in Gut‐Brain Axis and TLR4 /Myd88/ MAPK Pathway Inhibition

Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with cognitive decline and neuroinflammation. Xanthoceras sorbifolia Bunge oil (XSBO), a woody plant oil rich in bioactive fatty acids, has shown potential health benefits. This study aimed to investi...

A PPO-based PI tuning scheme for pitch control of floating offshore wind turbines

Abstract Blade pitch control is critical for stabilizing floating offshore wind turbines (FOWTs) in above-rated regions. However, conventional proportional-integral (PI) controllers, typically derived from simplified linear models, often suffer from model mismatch and limited cap...

Immuno-PET imaging of mesothelin in ovarian cancer with 68Ga-XH04: a first-in-human study

Mesothelin is highly expressed in ovarian cancer and represents a promising target for precision imaging and therapy. This study aimed to develop and evaluate ⁶⁸Ga-XH04, a novel mesothelin-targeted immuno-PET tracer for non-invasive imaging of mesothelin expression in preclinical...

Mapping the senescent stromal landscape and altered the immune microenvironment in PCOS endometrium

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting approximately 10% of reproductive-aged women and is a major cause of infertility. Inadequate endometrial receptivity is a pivotal contributor to this infertility, but its underlying cellular mechanisms r...

Short-Term Ground Gust Prediction Based on Fusion of Ground and High-Altitude Meteorological Data and Differential Polynomial Modeling

Accurate Short-term forecasting of gusts at 10 m above ground level is challenging because gridded meteorological variables exhibit persistence, nonstationarity, and abrupt transitions. This study proposes a Temporal Adaptive Difference Polynomial Network (TADPN) using 8760 hourl...

Local Shocks and Regional Dynamics in an Aging Economy

ABSTRACT This paper studies how population aging shapes regional adjustment to local shocks. I develop a dynamic spatial general equilibrium model that incorporates aggregate demographic change, life‐cycle variation in migration and employment choices, and forward‐looking investm...

The making of cells and organs in xenogeneic animal bioreactor

ABSTACT: For patients with end-stage organ dysfunction, organ transplantation is the only viable treatment option. However, the most significant challenge at present is the severe shortage of donor organs, and no technology exists that allows for long-term, sustainable organ gene...

Low Indium and Silver Consumption for High‐Efficiency Silicon Heterojunction Solar Cells: Simulating Design of Multilayer TCO and Silver‐Coated Copper Electrodes

The rapid scaling of silicon heterojunction (SHJ) solar cell manufacturing is constrained by the scarcity and price volatility of indium and silver. In this study, a low‐indium and low‐silver SHJ cell structure was designed by Sentaurus TCAD optoelectronic simulation. The optimiz...

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...

AI‐Assisted Tumor Boundary Delineation via Targeted Ultrasmall Iron Oxide Nanoprobe for High‐Contrast HER2‐Positive Tumor Imaging

ABSTRACT Breast cancer continues to be a leading cause of cancer‐related mortality in women globally, where precise diagnosis and clear tumor demarcation are critical for effective treatment. Herein, we developed a strategic platform that combines a novel ultrasensitive magnetic...

Universal Battery Capacity Degradation Forecasting Driven by Foundation Models Across Diverse Chemistries and Conditions

ABSTRACT Accurate forecasting of battery capacity fade is essential for the safety, reliability, and long‐term efficiency of energy storage systems. However, the heterogeneity across cell chemistries, form factors, and operating conditions makes it difficult to build a single mod...

Observation of Magnetic‐Anisotropy Crossover and High‐Temperature Skyrmions in the Dirac Magnet Fe 3 Ge with a Distorted Kagome Lattice

ABSTRACT Topological materials that simultaneously host robust high‐temperature skyrmions and nontrivial electronic band structures have attracted tremendous interest owing to their distinctive advantages for both fundamental research and prospective technological applications. H...

Data‐Efficient Cycle‐Level Capacity Prediction Using 1D Deep Convolutional Network

Fundamental battery research is constrained by the time‐consuming process of long‐term charge–discharge cycling stability testing. Here, we introduce DeepBat, a deep learning framework designed to shorten cycling tests by achieving accurate, long‐horizon prediction of cycle‐level...

Formation and Mitigation of Carbon Contamination in Electron‐Beam Measuring Instruments

ABSTRACT Carbon contamination in electron‐beam measuring instruments is a common problem that adversely affects sample observation and analysis. Although numerous scholars have conducted systematic and in‐depth research on this issue, identifying optimal imaging conditions to min...

The potential of exercise-induced bile acid metabolism remodeling in cardiovascular protection

Cardiovascular diseases (CVDs) persist as a predominant global health burden, necessitating the refinement of accessible preventive strategies beyond conventional pharmacotherapy. While physical exercise is universally acknowledged as a cornerstone of cardiovascular prevention, i...