Sapienza University of Rome

Phenotype-based appropriateness of IGM-enriched polyclonal immunoglobulin use in critical illness: report of an expert consensus

Sepsis and septic shock result from a dysregulated host response to infection, encompassing both hyperinflammatory and immunosuppressed phenotypes. Although immunomodulatory adjunctive therapies have been extensively investigated over the past decades, none have demonstrated cons...

Alzheimer’s disease classification using dynamic geometric pattern map: A novel image representation of EEG signals

Electroencephalography (EEG) offers a non-invasive and low-cost basis for computer-aided dementia detection, but existing systems face limitations: data-dependent feature representations, deep models that process channels independently and discard inter-channel spatial topology,...

Amphiphilic Motif Triggers Microheterogeneity in Low‐Melting Mixtures

Microheterogeneity in low‐melting mixtures of ethylene glycol and chemically modified choline derivatives synthesized on purpose is here proposed. Novel cholinium ions with one or two N ‐butyl substituents or an N ‐hydroxybutyl chain are synthesized for the first time. Synthesis...

Internalized weight stigma and associated clinical features in treatment-seeking adults with obesity: a multicenter Italian study

Abstract Background This study aimed to evaluate the prevalence and clinical correlates of internalized weight stigma in patients with obesity seeking treatment in various clinical centers across Italy. Methods A total of 438 patients with obesity were included. Patients complete...

The Large Deviation Principle for the Stochastic 3D Primitive Equations with Transport Noise

Abstract We prove the small-noise large deviation principle for the three-dimensional primitive equations with transport noise and turbulent pressure. Transport noise is important for geophysical fluid dynamics applications, as it takes into account the effect of small scales on...

Mosco-Convergence of Convex Sets and Unilateral Problems for Differential Operators with Lower Order Terms Having Natural Growth

We study the stability of solutions to a class of variational inequalities posed on obstacle-type convex sets, under Mosco-convergence. Specifically, we consider problems of the form {u∈W01,p(Ω)∩L∞(Ω),u≥ψ in Ω,⟨A(u),v−u⟩+∫ΩH(x,u,Du)(v−u)≥0,∀ v∈W01,p(Ω)∩L∞(Ω),v≥ψ in Ω. Here, A is...

Surgical treatment of complex scapular fractures: a single centre prospective observational study

Abstract Background Conservative management is traditionally preferred for scapular fractures, but recent studies suggest that surgical intervention may improve outcomes in selected patients. This study evaluates functional and imaging outcomes, complication rates, and under-repo...

Strength of the upper bounds for the Edge-Weighted Maximum Clique Problem

We theoretically and computationally compare the strength of the three main upper bounds from the literature on the optimal value of the Edge-Weighted Maximum Clique Problem (EWMCP). We provide a set of instances for which the ratio between any of the three upper bounds and the o...

Long-term outcomes and treatment cost estimates of flavonoids and polidocanol foam sclerotherapy for hemorrhoidal disease: a retrospective cohort study

Abstract Background Flavonoids and sclerotherapy are first-line treatments for hemorrhoidal disease (HD), but direct comparisons of long-term outcomes, patient satisfaction, and economic estimates are limited. Methods This single-center retrospective study included consecutive pa...

Combined SGLT-2 Inhibitor and Mineralocorticoid Receptor Antagonist Therapy: Effects on the Renin–Angiotensin–Aldosterone System in Heart Failure Treatment

Sodium–glucose cotransporter 2 inhibitors (SGLT2is), originally developed as glucose-lowering agents for type 2 diabetes mellitus, have increasingly demonstrated clinical benefits in patients with chronic kidney disease and heart failure. We retrospectively evaluated 114 patients...

Becoming post-Neolithic: Social Process and Transformation in Southern Italian Deathways

Abstract Models of how the European Neolithic transitioned to the Copper or Bronze Age have often emphasised changes in burial practices, and these changes have traditionally been seen as simple, decisive shifts. In peninsular Italy, this transition is often described in terms of...

Deciphering Molecular Charge Anisotropy: The Case of Antibody Solutions

Electrostatic interactions fundamentally govern the structure, stability, and dynamics of charged (bio)matter, yet the impact of heterogeneous and anisotropic charge distributions on the behavior of protein solutions remains elusive. Here, we introduce a versatile multiscale fram...

Sport, exercise, and physical activity in children with cardiovascular disease. A Clinical Consensus Statement of the European Association of Preventive Cardiology (EAPC) of the ESC, the Association of Cardiovascular Nursing & Allied Professions (ACNAP) of the ESC, and the Association for European Paediatric and Congenital Cardiology (AEPC)

Regular physical activity offers numerous benefits to children's health and well-being and is essential for reducing cardiovascular risk in children with cardiovascular disease. Despite increasing evidence supporting its benefits, many young patients remain insufficiently active...

Compact latent-space encoding of WGM microlaser spectra for fast and accurate sensing

The synergy between resonant photonics and artificial intelligence is emerging as a new paradigm capable of overcoming long-standing limitations of conventional methods used to analyze measurement outcomes. Automated data analysis is a crucial step in the development of fast, rel...

Antibody-Dependent Cellular Phagocytosis and Cytotoxicity in Patients With LGI1 and CASPR2 Encephalitis

This database includes the raw data linked with the paper “ Antibody-dependent cellular-phagocytosis and -cytotoxicity in patients with LGI1 and CASPR2 encephalitis”. Objective: Antibodies against LGI1 and CASPR2 (LGI1/CASPR2-IgG) associate with forms of autoimmune encephalitis (...

An Ultra-Compact Wavelet-Enhanced Hybrid Framework for Real-Time Edge Deepfake Detection: Experimental Validation on an NVIDIA Jetson Orin Nano

Deepfake manipulation has become increasingly difficult to detect as generative models continue to produce highly realistic facial content. This work presents the Frequency-Aware Lightweight Hybrid Network (FALH-Net Lite), a compact deepfake classification framework that combines...

Toxicants Released from Cigarette Butt and Other Tobacco and Nicotine Product Waste and Their Ecotoxicological Impact: A Systematic Review with One Health Perspectives

Cigarette butt waste is a widespread form of tobacco-related litter and an increasingly recognized source of environmental contamination. This systematic review synthesized evidence on the environmental impacts of cigarette butts and other tobacco and nicotine product waste, incl...

High-fat diet promotes T cell–mediated synaptic dysfunction in multiple sclerosis

Early glutamatergic synaptopathy contributes to disease progression in multiple sclerosis (MS), leading to excitotoxic synaptic damage. Although high-fat diet (HFD)–associated peripheral inflammation has been linked to central nervous system dysfunction, how metabolic and immune...

Wild Boar-Related Injuries in Wilderness Environments: Field-Oriented Management Principles and Evidence-Informed Clinical Recommendations

Wild boar-related trauma is uncommon but may result in severe injuries that pose diagnostic and therapeutic challenges, particularly in wilderness or resource-limited environments. Most scientific literature consists of isolated case reports, regional series, and forensic descrip...

Scale invariance in the high-frequency marine soundscape: diel oscillations as a proxy for ecosystem state

Life generated in the oceans. Human activities rapidly and drastically altered marine environments. Scientists are struggling in defining an effective strategy to assess the anthropogenic impacts into seas and oceans. In fact, marine ecosystems are complex systems, with a multitu...