Sapienza University of Rome

Characterizing End-User Auditing of Recommender System Behaviors Affecting Music Discoverability: a Diary Study

Recommender systems shape what people encounter online, yet their role in facilitating or constraining music discoverability is rarely examined from the listener’s perspective. To help address this gap, we present a two-week diary study with nine Italian young adults who reported...

Surveillance, Detection and Therapeutic Innovation in Antimicrobial Resistance in the Age of Polycrisis: From Genomic and Digital Innovation to One Health Integration

Antimicrobial resistance (AMR) surveillance is increasingly strained by interconnected global crises, i.e., pandemics, climate change, armed conflicts, population mobility, and health inequalities, that disrupt healthcare delivery, diagnostic capacity, and laboratory infrastructu...

Preliminary evidence of long‐term safety and effectiveness of anti‐ CGRP drugs for migraine prevention in people with comorbid epilepsy: A 52‐week follow‐up retrospective study

Abstract Migraine and epilepsy frequently coexist, but evidence on the safety of calcitonin gene‐related peptide (CGRP)‐targeting therapies in people with epilepsy is lacking. We evaluated long‐term migraine and epilepsy outcomes in a real‐world multicenter retrospective cohort o...

Travel distance to tertiary healthcare reflects disease severity and medication access in Italian systemic sclerosis patients: a geographical study on adult-onset rare diseases from SPRING-SIR registry

Systemic sclerosis (SSc) is a rare, multiorgan disease in adults that requires specialized care. Commuting to tertiary medical centers poses a considerable burden and incurs significant costs, potentially affecting management choices. This study aims to describe the healthcare co...

Simplification and Derivatization of Quinoline-Containing M41 Lead to the Discovery of NADPH Oxidase Isoform-Selective Inhibitors Effective in Cancer Cells

Abstract NADPH oxidases (NOXs) are attractive but challenging drug targets. Starting from M41 and its analog MC4876, we synthesized quinoline-based derivatives. SAR studies revealed that modifications at the quinoline C2 position and the amine-moiety influenced potency and isofor...

Multiscale Method for Estimating the Thermal Properties of Sandwich Materials Using Infrared Thermography

Characterizing the thermal properties of sandwich materials remains complex because it demands a method that can independently analyze both the thin and thick layers within the same sample. We propose combining flash and step thermography methods with analytical modeling based on...

Phytochemical Investigation and In Vitro Assessment of Antioxidant, Anti‐Inflammatory and Immunomodulatory Properties of Melia azedarach Linn. Extract in Chicken Lymphocyte Model

ABSTRACT Melia azedarach Linn. (chinaberry), a medicinal plant native to tropical Asia, is a rich source of diverse bioactive compounds with reported pharmacological activities and promising therapeutic potential. Despite its recognized phytochemical richness and biological prope...

From orthogonal shortening to transpression: The >20 Myr polyphase structural and thermal evolution of the Carboneras fault in the Betics, SE Spain

The architecture of mature faults commonly reflects long-lasting, cumulative tectonic histories marked by multiple episodes of deformation localization, fluid inflow, and variable slip behaviors. Hence, reconstructing fault tectonic histories and associated seismotectonic pattern...

Muscular Response in Sleep-Disordered Breathing Patients: New Methods of Assessment and Measurement

Background: Obstructive sleep apnea (OSA) is a heterogeneous disorder influenced by both anatomical collapsibility and non-anatomical factors, such as neuromuscular response. Identifying these traits through simplified clinical surrogates is crucial for personalized precision med...

Willingness to Participate in HIV Cure Research Among Young People Living with Perinatally Acquired HIV in the Centre Region of Cameroon: A Cross-Sectional Survey

Young people living with perinatally acquired HIV (YPLHIV) represent a unique population for HIV cure research, offering opportunities to assess interventions in a group for whom adherence to antiretroviral treatment (ART) is particularly challenging. Understanding their perspect...

Local Structure and Dynamics of Three-Dimensional Covalent Organic Frameworks

Abstract Resolving and controlling the local dynamical properties of covalent organic frameworks (COFs) remains a central challenge, particularly when assembled from large, flexible building units. Here, we combine synchrotron X-ray pair distribution function (PDF) analyses with...

How personality traits shape susceptibility to mental distress in times of crisis: Evidence from the COVID-19 pandemic

Empirical evidence indicates that societal crises and adverse conditions can negatively impact population mental health. The Big Five personality traits – neuroticism, extraversion, openness, agreeableness, and conscientiousness –significantly influence stress responses. In this...

Diagnosing Lennox–Gastaut syndrome in adulthood: A scoping review of diagnostic challenges and age‐related electroclinical evolution

OBJECTIVE: Lennox-Gastaut syndrome (LGS) is a developmental and epileptic encephalopathy typically diagnosed in childhood. The 2022 International League Against Epilepsy (ILAE) criteria provide a diagnostic framework built on pediatric data, but their applicability in adulthood i...

When the fat is missing: a fat-free spindle cell lipoma in a young woman

Dear Editor, Spindle cell lipoma (SCL) is a benign adipocytic neoplasm first characterized by Enzinger and Harvey, classically arising in the posterior neck, shoulder, and upper back of middle-aged to older men. Histologically, it is defined by a variable admixture of mature adip...

Large-Scale Cerebellar-Cerebral Network Alterations Underlying Impaired Social Predictive Processing in Cerebellar Neurodegeneration

Abstract The cerebellum is a key node for detecting and adjusting social-prediction internal models. Yet social prediction has been scantly investigated in neurodegenerative cerebellar patients (CB). Thus, we examined CB social-prediction abilities and related cerebellar-cerebral...

How Crystallite Size and Topology Control Intrusion–Extrusion Hysteresis in Metal–Organic Frameworks

Heterogeneous lyophobic systems (HLSs) are of interest for diverse applications, including energy materials and column chromatography. Within these systems, tuneability is a key property to broaden the scope of application. In this work, we explore how the exogeneous property of...

Merkel Cell Polyomavirus and DNA Damage Response

Cellular DNA is constantly exposed to endogenous and exogenous genotoxic factors causing mutations. Therefore, safeguarding the integrity of the human genome is a conditio sine qua non for normal cell function. To maintain genomic integrity, complex multiprotein networks, known a...

Integrated Valorization of Plastic Waste into Synthetic Fuels and Electricity via Multi-Stage Upgrading: Process Modeling and Techno-Economic Analysis

Abstract An integrated process for the valorization of 1000 kg/h of heterogeneous plastic waste (Plasmix) into hydrogen, purified CO2, light and heavy liquid fuels, and electricity was developed and simulated using Aspen Plus. The process combines non-catalytic pyrolysis with seq...

Anisakid biodiversity in the pygmy sperm whale ( Kogia breviceps ) stranded along the Spanish Atlantic coast

Abstract Anisakid nematodes are widespread parasites of marine mammals, characterized by complex life cycles involving invertebrate and fish hosts. While these parasites generally exhibit low specificity for intermediate hosts, they often show distinct associations with definitiv...

The Relationship Between Orthognathodontics and Physiotherapy: A Scoping Review

Background/Objectives: The increasing complexity of the most common conditions that require orthodontic or gnathological interventions may need physiotherapeutic evaluation and treatment. This link is increasingly relevant in patients who suffer from temporo-mandibular and cranio...