Sapienza University of Rome

3D Imaging Without Light-Sheet: An Accessible Tissue-Clearing and Confocal Workflow for Human Cortical and Retinal Organoids

Human induced pluripotent stem cell (iPSC)-derived neural organoids have emerged as valuable models for investigating human neurodevelopment and neurological disorders. However, their complex three-dimensional architecture poses significant challenges for conventional histologica...

Wall-temperature effects in a turbulent hypersonic boundary layer in chemical non-equilibrium

Hypersonic vehicles operate in extreme environments where intense aerodynamic heating, wall heat transfer and thermochemical non-equilibrium are tightly coupled. In this regime, wall temperature plays a pivotal role in mediating the interaction between turbulence, thermal transpo...

DISE and Rhinomanometry Correlates of Response to Head‐of‐Bed Elevation in Obstructive Sleep Apnea

OBJECTIVES: To identify endoscopic and rhinomanometric correlation of response to 30° head-of-bed elevation (HOBE) in patients with obstructive sleep apnea (OSA), and to explore whether upper airway (UA) collapse patterns and nasal resistance are associated with positional improv...

Lean Mass Reduction During Glucagon-like Peptide-1 Receptor Agonists-Induced Weight Loss: Rethinking Its Clinical Significance

The substantial weight loss achieved with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual incretin agonists has transformed the management of obesity and cardiometabolic risk. However, the accompanying reduction in lean mass has raised concerns regarding potential...

Profiling immune check point inhibitors – Induced arthritis: A systematic review and pooled analyses of cohort studies

Background The growing use of immune checkpoint inhibitors (ICIs) in the oncology field along with the potential development of the so-called immune-related adverse events (irAEs) has introduced new diagnostic and therapeutic challenges for rheumatologists. Rheumatic irAEs (Rh-ir...

Nature of the Localized V 3 d Electrons in Mo- and W-Doped BiVO4 Revealed by Soft X-ray Photoemission and Absorption Spectroscopy

Abstract We have investigated the effects of Mo and W doping on BiVO4 by means of X-ray photoemission spectroscopy (XPS) and X-ray absorption spectroscopy (XAS). The V 2p XPS spectra indicate that the substitution of W6+ and Mo6+ for V5+ induces the formation of V4+ species. In a...

The Association Between Relative Deprivation and Aggression: A Three-Level Meta-Analysis

Previous research regarding the association between relative deprivation and aggression has yielded inconsistent findings, and the moderating mechanisms underlying this association remain underexplored. In this study, we evaluated the association between relative deprivation and...

Tachinidae (Diptera) as Floral Visitors and Pollinators in Natural and Managed Systems

ABSTRACT Awareness of the roles of flies as pollinators in natural and agricultural ecosystems has increased considerably in recent years, and there is growing consensus that globally they rank second in importance as floral pollinators after the Hymenoptera. The bristle flies (T...

Deep Learning for Quantitative Perfusion 99mTc-ECD SPECT in Clinically Confirmed Neuropsychiatric Systemic Lupus Erythematosus: Comparison with Established Software

Abstract Purpose We compared a novel deep learning (DL)-based quantification software (BTXBrain) with an established platform (Q.Brain) for quantitative perfusion single photon emission computed tomography (SPECT) in patients with clinically confirmed neuropsychiatric systemic lu...

Foot segments motion during uneven terrain walking and influence on lower limb biomechanics

Abstract Human locomotion has been extensively studied on flat ground; however, everyday walking often occurs on uneven terrain, which poses additional biomechanical challenges. The role of foot segmental mobility under these conditions remains underexplored. This study investiga...

A Semi-Lagrangian Method for Solving State Constraint Mean Field Games in Macroeconomics

Abstract. We study continuous-time heterogeneous agent models cast as Mean Field Games, in the Aiyagari–Bewley–Huggett framework. The model couples a Hamilton–Jacobi–Bellman equation for individual optimization with a Fokker–Planck–Kolmogorov equation for the wealth distribution....

KDM6A loss enhances oxidative phosphorylation uncovering tissue-level convergent evolution

Abstract The tumor suppressor KDM6A / UTX , a histone demethylase and a 2-oxoglutarate-dependent dioxygenase, is frequently lost in many cancer types. We show that KDM6A loss pervasively activates oxidative phosphorylation in several solid tumors, generating a pseudo-hyperoxic en...

A novel model-based biclustering for ordinal data via a URV approach

Abstract We introduce a novel finite mixture model for biclustering ordinal data matrices, simultaneously clustering rows and columns within the Underlying Response Variable (URV) framework. Ordinal responses are modeled as discretizations of latent Gaussian variables, while comp...

A gridded dataset of European Forest Types to support forest monitoring, modelling and reporting

Abstract. A standardized system of nomenclature for forest types is essential for effectively monitoring and understanding the impacts of climate change on diverse ecosystems in Europe and beyond. A comprehensive classification system, such as the European Forest Types (EFTs) sch...

From Classification to Convergence: Transformations of Literary Genre in the Transmedia Ecosystem

This article examines the evolution of literary genres within the contemporary media ecosystem shaped by convergence culture and participatory practices. Traditionally understood as classificatory and normative frameworks, genres are increasingly challenged by transmedia storytel...

Addressing fusiform gyrus dysfunction in schizophrenia, theory of mind, and implications for antipsychotics’ response and resistance: A systematic review and critical appraisal

Background The Fusiform Gyrus (FG), a brain region relevant for the interaction between cognitive processes and emotional behavior, especially emotion recognition and interpretation of social cues, has been linked to the pathophysiology of schizophrenia conceptualized as a disord...

Outdoor Environmental Comfort, Public-Space Use and Perceived Sociability Among Ageing Populations: Integrating Field Surveys and Microclimatic Simulations

Outdoor environmental comfort is increasingly relevant amid climate change and population ageing because it affects well-being, behaviour and public-space use. However, the relationship between microclimatic conditions, environmental perception, and public-space use among older a...

Analysis of Io's tidal response as a function of the properties of the partially molten layer

Introduction Jupiter’s moon Io, the most volcanically active body in the Solar System [1][2], exhibits intense internal heating believed to be driven by tidal friction. While tidal dissipation is widely accepted as the primary mechanism powering this volcanic activity, the spatia...

Safety culture and high reliability in public utility services: evidence from the Italian urban hygiene sector

Purpose Despite substantial improvements in workplace safety at managerial and organizational levels over recent decades, accident rates remain high, with considerable social and economic impacts. This study explores the links between safety culture and high reliability organizat...

Cemiplimab in cutaneous squamous cell carcinoma: a longer follow‐up study focusing on the late toxicities

Summary Background and Objectives Cemiplimab was the first systemic therapy approved for advanced cutaneous squamous cell carcinoma (cSCC). Patients and Methods We report findings from the Italian early access program cohort, comprising 134 patients treated with cemiplimab, with...