Sapienza University of Rome

Local Structure and Dynamics of Three-Dimensional Covalent Organic Frameworks

Abstract Resolving and controlling the local dynamical properties of covalent organic frameworks (COFs) remains a central challenge, particularly when assembled from large, flexible building units. Here, we combine synchrotron X-ray pair distribution function (PDF) analyses with...

Muscular Response in Sleep-Disordered Breathing Patients: New Methods of Assessment and Measurement

Background: Obstructive sleep apnea (OSA) is a heterogeneous disorder influenced by both anatomical collapsibility and non-anatomical factors, such as neuromuscular response. Identifying these traits through simplified clinical surrogates is crucial for personalized precision med...

How personality traits shape susceptibility to mental distress in times of crisis: Evidence from the COVID-19 pandemic

Empirical evidence indicates that societal crises and adverse conditions can negatively impact population mental health. The Big Five personality traits – neuroticism, extraversion, openness, agreeableness, and conscientiousness –significantly influence stress responses. In this...

Willingness to Participate in HIV Cure Research Among Young People Living with Perinatally Acquired HIV in the Centre Region of Cameroon: A Cross-Sectional Survey

Young people living with perinatally acquired HIV (YPLHIV) represent a unique population for HIV cure research, offering opportunities to assess interventions in a group for whom adherence to antiretroviral treatment (ART) is particularly challenging. Understanding their perspect...

When the fat is missing: a fat-free spindle cell lipoma in a young woman

Dear Editor, Spindle cell lipoma (SCL) is a benign adipocytic neoplasm first characterized by Enzinger and Harvey, classically arising in the posterior neck, shoulder, and upper back of middle-aged to older men. Histologically, it is defined by a variable admixture of mature adip...

Diagnosing Lennox–Gastaut syndrome in adulthood: A scoping review of diagnostic challenges and age‐related electroclinical evolution

OBJECTIVE: Lennox-Gastaut syndrome (LGS) is a developmental and epileptic encephalopathy typically diagnosed in childhood. The 2022 International League Against Epilepsy (ILAE) criteria provide a diagnostic framework built on pediatric data, but their applicability in adulthood i...

Large-Scale Cerebellar-Cerebral Network Alterations Underlying Impaired Social Predictive Processing in Cerebellar Neurodegeneration

Abstract The cerebellum is a key node for detecting and adjusting social-prediction internal models. Yet social prediction has been scantly investigated in neurodegenerative cerebellar patients (CB). Thus, we examined CB social-prediction abilities and related cerebellar-cerebral...

Merkel Cell Polyomavirus and DNA Damage Response

Cellular DNA is constantly exposed to endogenous and exogenous genotoxic factors causing mutations. Therefore, safeguarding the integrity of the human genome is a conditio sine qua non for normal cell function. To maintain genomic integrity, complex multiprotein networks, known a...

How Crystallite Size and Topology Control Intrusion–Extrusion Hysteresis in Metal–Organic Frameworks

Heterogeneous lyophobic systems (HLSs) are of interest for diverse applications, including energy materials and column chromatography. Within these systems, tuneability is a key property to broaden the scope of application. In this work, we explore how the exogeneous property of...

Integrated Valorization of Plastic Waste into Synthetic Fuels and Electricity via Multi-Stage Upgrading: Process Modeling and Techno-Economic Analysis

Abstract An integrated process for the valorization of 1000 kg/h of heterogeneous plastic waste (Plasmix) into hydrogen, purified CO2, light and heavy liquid fuels, and electricity was developed and simulated using Aspen Plus. The process combines non-catalytic pyrolysis with seq...

The Relationship Between Orthognathodontics and Physiotherapy: A Scoping Review

Background/Objectives: The increasing complexity of the most common conditions that require orthodontic or gnathological interventions may need physiotherapeutic evaluation and treatment. This link is increasingly relevant in patients who suffer from temporo-mandibular and cranio...

Anisakid biodiversity in the pygmy sperm whale ( Kogia breviceps ) stranded along the Spanish Atlantic coast

Abstract Anisakid nematodes are widespread parasites of marine mammals, characterized by complex life cycles involving invertebrate and fish hosts. While these parasites generally exhibit low specificity for intermediate hosts, they often show distinct associations with definitiv...

Self‐Assembly of a Colloidal Honeycomb Crystal in Silico for Topological Valley Photonics

The quest to employ colloidal self-assembly as a scalable means of fabricating photonic crystals with a complete photonic band gap at optical frequencies has proved challenging throughout the first quarter of the 21st century. Meanwhile, the field of topological photonics has eme...

Extra Dimensions, Exotic Matter like 17MeV and Dark Matter Triple String Framework

Extra Dimensions, Exotic Matter like 17 MeV and Dark Matter Triple String Framework introduces a unified theoretical model connecting extra-dimensional geometry, exotic matter, dark-sector resonances, and cosmological anomalies. The framework is built on a binary SU(2)–CP²–SU(3)...

Extra Dimensions, Exotic Matter like 17MeV and Dark Matter Triple String Framework

Extra Dimensions, Exotic Matter like 17 MeV and Dark Matter Triple String Framework introduces a unified theoretical model connecting extra-dimensional geometry, exotic matter, dark-sector resonances, and cosmological anomalies. The framework is built on a binary SU(2)–CP²–SU(3)...

Serotonergic Toxicity and Hyponatremia Associated with Antidepressant Therapy: The Pivotal Role of SIADH

Serotonin syndrome (SS) and the syndrome of inappropriate antidiuretic hormone secretion (SIADH) are well-recognized adverse drug reactions (ADRs) associated with serotonergic agents, particularly antidepressants. Although traditionally regarded as distinct clinical entities, acc...

Genetic algorithm-supervised graph shadow estimation for low-observability distribution feeders: calibrated validation on a real feeder

Real distribution feeders often operate under partial observability, while physics-based state estimators can be too slow for frequent digital-twin updates. This paper proposes a Genetic Algorithm (GA)-supervised graph surrogate for shadow state estimation using feeder topology,...

The Picard group of the Baily–Borel compactification of the moduli space of quasi-polarized K3 surfaces and generalizations

Abstract We investigate the Picard group of the Baily–Borel compactification of orthogonal Shimura varieties. In particular, we show that the Picard group of the Baily–Borel compactification of the moduli space of quasi-polarized K3 surfaces is isomorphic to ℤ. Notably, this cont...

Composite Likelihood Inference for Simultaneous Clustering and Dimensionality Reduction of Multivariate Mixed-Type Longitudinal Data

Abstract We propose a novel multivariate hidden Markov model (HMM) designed to analyze longitudinal mixed-type data comprising continuous and ordinal variables. Our model identifies and prioritizes discriminative dimensions, i.e., those useful for clustering, while separating the...

Subadditivity and optimal matching of unbounded samples

We obtain new bounds for the optimal matching cost for empirical measures with unbounded support. For a large class of radially symmetric and rapidly decaying probability laws, we prove for the first time the asymptotic rate of convergence for the whole range of power exponents p...