New York University

Adolescent Dating Violence Victimization and Suicidal Thoughts and Behaviors: A Systematic Review

ABSTRACT Introduction Suicide is a leading cause of death among adolescents, highlighting the importance of identifying interpersonal experiences associated with suicidal thoughts and behaviors (STBs). Adolescent dating violence (ADV), encompassing physical, sexual, psychological...

Shaping light in 3D for direct asymmetric photochemistry: a 1000-fold enantioselectivity enhancement

Abstract Shaping electronic motion with tailored light enables unprecedented control over matter: from realising topological states in quantum materials to steering chemical reactions along specific pathways. Yet, despite the vital roles of molecular chirality across nature, stan...

What does ChatGPT want? An interpretationist guide

This paper investigates LLMs from the perspective of interpretationism, a theory of belief and desire in the philosophy of mind. We argue for three conclusions. First, the right object of study for LLM psychology is the instance agent (initialized at the start of each context), n...

Intra-tumoral epigenetic heterogeneity and aberrant molecular clocks in hepatocellular carcinoma

There is limited understanding of the epigenetic drivers of tumor evolution in hepatocellular carcinoma (HCC). Here we characterize the epigenetic contribution of methylation to intra-tumoral heterogeneity (mITH) using regional enhanced reduced-representation bisulfite sequencing...

Trends in GLP-1 Receptor Agonist Prescriptions for Children Ages 8 to 11 With Obesity: 2019–2026

BACKGROUND AND OBJECTIVES: Clinical practice guidelines for pediatric obesity management allow for consideration of glucagon-like peptide-1 receptor agonists (GLP-1RA) in children ages 8-11. No study has documented secular trends in GLP-1RA prescribing in this group. We hypothesi...

Coarse-Grained Nonadiabatic Dynamics in Disordered Condensed Phases

Abstract The mechanisms underlying critical energy-gap fluctuations and nonadiabatic dynamics in disordered condensed phases remain elusive, and their accurate simulation poses a challenge due to the inherent complexity of these systems. In this study, we make the first attempt t...

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene

Malignant hyperthermia (MH) is a life-threatening pharmacogenetic condition triggered by volatile anesthetics, which activate pathogenic RyR1 mutants. The small molecule therapeutic dantrolene has long been used to treat MH. However, the binding site and mechanism of dantrolene r...

Estimating the Internal Rate of Return of the Influential Jamaica Early Childhood Intervention

Abstract This article quantifies the economic benefits of an influential early childhood program in a developing country, tracking participants with outcomes measured through age 31 years. Drawing on published experimental data encompassing life-cycle benefits – that rely primari...

Complementary vertebrate Wac models exhibit phenotypes relevant to DeSanto-Shinawi Syndrome

Monogenic syndromes are associated with neurodevelopmental changes that result in cognitive impairments and neurobehavioral phenotypes, including autism and seizures. Limited studies and resources are available to make meaningful headway into the underlying molecular mechanisms t...

Berberine Inhibits Eczematous Skin S. aureus-Induced Mast Cell/Basophil Activation and Modulates MAPK-Associated Gene Expression

Staphylococcus aureus (S. aureus), a primary exacerbating factor in eczema, remains a prevalent pathogenic public-health threat. The mechanism of mast cell/basophil degranulation in the context of S. aureus-exacerbated eczema remains unclear. We sought to investigate the direct e...

Equity Frictions and Firm Ownership

Abstract In this paper, I document systematic heterogeneity in ownership and financing of firms across Eurozone countries. To rationalize these differences, I build a quantitative general equilibrium model of workers and entrepreneurs who choose debt and equity financing of their...

Prenatal Water Fluoride Exposure and Children’s Behavioral Problems

Importance Although fluoride exposure at high levels during the perinatal period has been associated with socioemotional problems among children, there is limited evidence regarding potential associations at lower levels of fluoride exposure, particularly in the US. Objective To...

CD37 impairs revascularization and muscle recovery in peripheral artery disease

Peripheral artery disease (PAD) affects more than 14 million Americans, and its most advanced form, critical limb-threatening ischemia (CLTI), is associated with chronic inflammation, poor tissue perfusion, and impaired skeletal muscle repair. Although tetraspanins are known to o...

Laser scanning registration for knee arthroplasty

Aims: Accurate registration of anatomy is fundamental to robotic and computer-assisted surgery; however, conventional methods rely on manual data acquisition performed by the surgeon using a tracked probe that is slow and affected by operator variability. Limitations of manual me...

Socializing in the Digital Era: Examining How Social Activities Influence Momentary Emotions in Mothers of Infants

Abstract The transition to parenthood is a period of heightened emotion; while deeply rewarding, it is also a stressful time, marked by an increased risk of mental health problems. Socializing is vital for parents’ mental health and may buffer these risks. However, little is know...

Clustering Neighborhood Economic Trajectories: Gentrification Stages, Executed Evictions, and Other Housing Characteristics in New York City

In recent years, gentrification has frequently been linked to housing inequality and mass evictions and portrayed in a negative light. This study defines gentrification in terms of neighborhood median household income, income diversity, and their level and trajectories over 14 ye...

Information Geometric Regularization of the Barotropic Euler Equation

Abstract. Shock waves in gas dynamics feature jump discontinuities that hinder numerical simulations. Viscous regularizations are prone to excessive dissipation of fine-scale structures. In this work, we propose the first inviscid regularization of the multidimensional Euler equa...

Temporally structured motor and auditory representations in covert syllable production

Inner speaking—the deliberate generation of speech through covert production mechanisms—is a common human experience. Current accounts propose that it engages sensorimotor processes similar to those underlying overt speech. Here, we asked whether motor and auditory representation...

An Experience-Sampling Approach to Examining Cortisol and Testosterone Profiles in Bipolar and Depressive Mood Disorders

Emotion dysregulation is a core component of bipolar disorder (BD). However, there is a critical gap concerning the measurement of emotion-relevant neuroendocrine processes in this population. The present investigation examined neuroendocrine profiles (i.e., cortisol and testoste...

Survival and hematologic toxicity after whole-brain radiotherapy, photon craniospinal irradiation, and proton craniospinal irradiation for solid-tumor leptomeningeal disease: a systematic review

Leptomeningeal disease (LMD) from solid tumors carries poor prognosis and substantial neurologic morbidity. Radiotherapy is used for palliation and disease control, but outcomes across whole-brain radiotherapy (WBRT), photon craniospinal irradiation (CSI), and proton CSI remain i...