New York University

Real‐world outcomes of nivolumab‐ AVD and brentuximab vedotin‐ AVD in paediatric and adult advanced‐stage Hodgkin lymphoma

Summary Brentuximab vedotin (BV)‐doxorubicin, vinblastine and dacarbazine (AVD) and nivolumab (N)‐AVD have transformed the frontline treatment of advanced‐stage Hodgkin lymphoma (HL), yet real‐world comparative data remain limited. In this multicentre retrospective study across 1...

Latent Class Analysis of Prenatal Characteristics and Their Associations With Early Childhood Weight

ABSTRACT Objective Identify patterns of obesity‐related prenatal characteristics across ecological system levels and examine associations with child weight at 2 years old. Methods Secondary analyses were conducted using data from 533 low‐income Hispanic families enrolled in a chi...

Scaling Long-Context LLMs via Unified KV Cache Optimization: A Comparative Study of Paged Attention and Quantization

The Key-Value (KV) cache is the dominant memory bottleneck in autoregressive large language model (LLM) inference, growing linearly with context length. This paper presents a systematic empirical study of three KV cache optimization strategies applied to Mistral-7B-Instruct-v0.2...

Scaling Long-Context LLMs via Unified KV Cache Optimization: A Comparative Study of Paged Attention and Quantization

The Key-Value (KV) cache is the dominant memory bottleneck in autoregressive large language model (LLM) inference, growing linearly with context length. This paper presents a systematic empirical study of three KV cache optimization strategies applied to Mistral-7B-Instruct-v0.2...

Structural Characterization of the Forensic Sodium Rhodizonate Test for Lead

Abstract The forensic sodium rhodizonate test is used to detect lead in gunshot debris. Areas of interest are sprayed with a sodium rhodizonate solution followed by a tartrate buffer solution of pH 2.8, producing a deep red compound indicative of lead and other metals. A confirma...

SATIN: a sparse attention application-specific instruction-set processor with custom mixed-precision extensions for energy-efficient edge inference of transformer large language models

Edge inference of Transformer large language models is constrained by the quadratic cost of self-attention and by the memory traffic of the key-value cache. Existing accelerators treat sparsity and mixed precision as separate fixed-function mechanisms and provide no accuracy guar...

Spatial extension of parafoveal processing predicts reading speed gain during reading acceleration

Fast and efficient reading involves not only processing the currently fixated word but also simultaneous processing of the upcoming text. Although the role of extrafoveal processing in natural reading has been extensively documented, its contribution to reading acceleration benef...

Expanding the Donor Pool: Successful Single Lung Transplant of a Hepatitis C Seropositive Donor to a Recipient With HIV and Pulmonary Fibrosis

Melissa Lesko, DO is on the advisory board for patientMpower, Ltd. (10/13 Thomas St. Dublin, Ireland). Bonnie Lonze, MD PhD has received research funding from AbbVie, Inc for work unrelated to this manuscript. The other authors declare no conflicts of interest.

Note on a Conjecture of Talagrand: Expectation Thresholds vs. Fractional Expectation Thresholds

We show that a restricted version of a conjecture of M. Talagrand on the relation between "expectation thresholds" and "fractional expectation thresholds" follows easily from a strong version of a second conjecture of Talagrand, on "selector processes". The selector process conje...

Prevalence and determinants of death registration across three demographic surveillance sites in Kenya

Abstract Background Death registration remains markedly incomplete in many low- and middle-income settings despite its importance in generating population statistics for health systems planning and monitoring of sustainable development goals. We assessed the completeness of death...

King sulfur

Mammalian cells produce and store a sulfur compound for antioxidant protection

Cheating by the Rules

Calculating candidate options.

Pediatric Literacy Promotion for Latino Families by Texts and Referrals: A 3-Arm RCT

OBJECTIVE: To test 2 strategies designed to enhance primary care-based literacy promotion (LP): (1) text message reminders (texts), and (2) texts plus referral to community resources. METHODS: We recruited 630 Latino caregiver-infant (aged 6 to 12 months) dyads for an effectivene...

The amyloid plaque proteomes of Alzheimer’s disease and mild cognitive impairment

Amyloid plaques contain numerous proteins in addition to amyloid beta in Alzheimer’s disease (AD). Previous localized proteomics identified plaque-associated proteins in late-onset AD, early-onset AD, rapidly progressive AD, preclinical AD, and AD in Down syndrome, although most...

Transition to Double‐Cell Mock Walker Circulations With Surface Warming Explained by Periodic Convection

Abstract Idealized mock Walker simulations are widely used to study the interactions between overturning circulation and convection in the tropics. Previous studies documented a transition from a single‐cell to a double‐cell mock Walker circulation when the average sea surface te...

CXCL1-CXCR2 signaling mediates cancer cell growth and response to radiation therapy in leptomeningeal metastasis

Leptomeningeal metastasis (LM) is a fatal neurological complication of cancer. Proton craniospinal irradiation (pCSI) has emerged as a promising life-prolonging intervention for patients with LM, but response to this treatment varies. Here, we aimed to characterize the molecular...

Spatial mixed models for assessing environmental exposure effects on the microbiome

Environmental exposures such as air pollution may influence human health partly through microbiome, but statistical modeling is challenged by spatial dependence across regions and ecological correlations among taxa. We propose SpaMixed, a novel spatial mixed modeling framework fo...

Managing through Closed Loops: the (Im)Possibility of Scale in China's Data-driven Governance

This paper examines what we call the (im)possibility of scale in China’s data-driven governance: while the promises of volume and growth of data suggest the possibility of governance at scale, our ethnography shows that it is impossible to realize in practice. Instead, on-the-gro...

Modeling the effect of drug courts in North Carolina counties

Abstract Background Illicit opioid overdose death rates drastically increased across North Carolina through 2023. We sought to study the impact of drug courts and what conditions can make their presence more or less effective. Methods We analyzed counts of illicit opioid overdose...

How Medical School Experiences Bias Specialty Selection: Perspectives From Current U.S. Otolaryngology Residents

Objectives: This study examined the medical school experiences of current U.S. otolaryngology residents to better understand gender biases that may persist within the specialty and to inform strategies that could improve workforce excellence. Methods: A voluntary, IRB-approved su...