New York University

Incidence, risk factors, and prognostic implications of hospitalizations for heart failure among patients with myeloproliferative neoplasms

Myeloproliferative neoplasms (MPNs), including essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF), are a group of chronic leukemias associated with increased risk of heart failure (HF). Despite a link between MPNs and HF, prognostic implications and ri...

Persistent chromatin alterations and gene expression reprogramming follow widespread DNA damage in glioblastoma

Abstract DNA damage from routine cellular processes or exogenous insults can have a lasting impact on gene regulation beyond genetic mutations. The prevailing paradigm for the consequences of DNA damage repair revolves around restoration of the original genetic sequence, but long...

Central complex representations of self-movement are sufficient to compute wind direction in flight

Flying flies can determine ambient wind direction in flight, but what neural representations might support this behavior are unclear. Ambient wind acting on a flying fly creates distinct patterns of airflow and optic flow. Here, we used two-photon imaging to characterize encoding...

Are Pediatric GLP ‐1 Receptor Agonist Cutaneous Adverse Events Being Overlooked? Emerging Age‐Specific Patterns and Their Implications for Dermatologists

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) use in children is rapidly expanding, though in contrast to adults, morphologic data on dermatologic adverse events (AEs) in pediatric patients remain sparse, underscoring the need for further focused investigation. We review...

DyAb: sequence-based antibody design and property prediction in a low-data regime

ABSTRACT Protein therapeutic design and property prediction are frequently hampered by data scarcity. Here we propose a new model, DyAb, that addresses these issues by leveraging a pair-wise representation to predict differences in protein properties, rather than absolute values....

Toward a Deeper Understanding of Predicting Risk of Cardiovascular Disease Events for 10‐Year Atherosclerotic Cardiovascular Risk: Subgroup Fairness and Predictive Value of Social Determinants of Health

BACKGROUND: The American Heart Association's Predicting Risk of Cardiovascular Disease Events model offers a modern, race-free approach to risk prediction, but its subgroup fairness and the added value of social determinants of health (SDOH) remain underexplored. METHODS: To eval...

How Norms Depend on the Presence and Status of Observers: The Relational Contingency of Everyday Behaviors in 90 Societies

Norms are fundamental to social life, but basic questions about how they are affected by social context remain. Specifically, how do normative constraints depend on the presence and status of observers, and how do such relational contingencies vary across cultures? Using data fro...

Assessing Psychiatric Symptoms in Autistic Youth Using the K-CAT®

Abstract Purpose While highly prevalent, mental health (MH) challenges in autistic youth often go unrecognized due in part to the lack of an accurate, comprehensive MH assessment tool. The K-CAT ® was developed to address barriers to identification of MH concerns in the general p...

Mentalizing and heuristics as distinct cognitive strategies in human teaching

Teaching is a foundational social behaviour that can result from mentally effortful reasoning or cognitively frugal heuristics. When do people use these strategies to teach? Here we investigated this using behavioural experiments and computational modelling with adult participant...

Bacterial ribonucleoprotein bodies maintain an acidic pH environment as a mechanism of enzyme regulation

Abstract Phase separated biomolecular condensates create subcellular niches, yet their role in client regulation remains unclear. Here, we demonstrate that Bacterial Ribonucleoprotein bodies (BR-bodies) are acidic. Using ratiometric fluorescent probes in vivo , we find BR-bodies...

Deep learning models for reliable weather forecasting in crowded regions performing traditional or religious activities

Forecasting weather during large-scale traditional or religious events in densely populated regions is particularly challenging because of the ever-evolving microclimatic changes caused by human activities. This study designed and tested two new deep learning-based approaches for...

Self-rankings as a predictor of scientific impact beyond peer review

Abstract Peer review in academic research aims to ensure factual correctness and identify work of high scientific potential, but rapid submission growth has made this increasingly difficult. Here we investigate an additional measure for identifying high-impact research: authors’...

Cyber resilience in next-generation networks: threat landscape, theoretical foundations, and design paradigms

The evolution of networked systems, driven by innovations in software-defined networking, network function virtualization, open radio access networks (O-RAN) and cloud-native architectures, is redefining both the operational landscape and the threat surface of critical infrastruc...

The interplay of air pollution with plasma neurodegenerative markers and metabolome for dementia, Parkinson’s disease and all-cause mortality risks and transitions: The UK Biobank study

We investigated the joint associations of circulating neurodegeneration markers—neurofilament light (NfL) and glial fibrillary acidic protein (GFAP)—ambient air pollution, and plasma metabolomic profiles with transitions from a healthy state to dementia, Parkinson’s disease (PD),...

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

Associations of ambient temperature and PM2.5 concentration with temporal variability in emergency department visits for acute gastrointestinal illnesses in central Bangkok, Thailand: a 5-year retrospective analysis

The combined effects of temperature and air pollution on acute gastrointestinal (GI) illnesses remain underexplored in tropical settings. This study examined the association between ambient temperature, fine particulate matter (PM2.5), and emergency department (ED) visits for gas...

Highlights of the 2025 American Joint Replacement Registry Annual Report

The 2025 American Joint Replacement Registry Annual Report includes 4.6 million hip and knee arthroplasty procedures, with 4,434,668 validated cases, representing a 20% increase from the prior report. Registry participation continues to expand, with contributions from over 5000 s...

Masonry Mortar with Carbide Sludge and Limestone for Enhanced Hydration and Carbonation Performance

Abstract This investigation utilized carbide sludge, predominantly composed of calcium hydroxide, with or without ground limestone, to partially replace portland cement for masonry mortar applications. Accelerated carbonation was employed to simulate the long-term environmental e...

Bayesian inference of lineage trees by joint analysis of single-cell multimodal lineage-tracing data with BiLinT

Abstract The advent of single-cell lineage-tracing technologies has enabled simultaneous measurement of gene expression and lineage barcodes. However, integrating these modalities for high-resolution lineage reconstruction has remained challenging due to limitations of methods th...

Hypothalamic representation of aggressiveness across mouse strains

Aggression is an innate behavior conserved across species, serving as a critical means to compete for food, mating opportunities, and other essential resources. A central question in aggression research is the extent to which inter-individual variability in aggression is shaped b...