New York University

Longitudinal weighted and trimmed treatment effects with flip interventions

Weighting and trimming are popular methods for addressing positivity violations in causal inference. While well-studied with single-timepoint data, standard methods do not easily generalize to longitudinal data and remain vulnerable to time-varying positivity violations. We exten...

Interpretable distillation reveals that deep learning splicing models suffer from pervasive confounders and blind spots

BACKGROUND: Predicting RNA splicing from genomic sequence is a crucial task for understanding gene regulation and interpreting genetic variation. Recent deep learning advancements have led to splicing prediction algorithms that achieve state-of-the-art performance compared to ear...

Itō and Itō-Wentzell chain rule for flows of conditional laws of continuous semimartingales: an easy approach

We provide a general Itō-Wentzell formula for a random field of maps on the Wasserstein space of probability measures, defined by continuous semimartingales, and evaluated along the flow of conditional distributions of another continuous semimartingale. Our method follows standar...

A biobank-scale method for learning modulators of gene-environment interaction underlying human complex traits from multiple environmental exposures

Abstract It is increasingly recognized that genetic effects on complex traits and diseases are shaped by environmental context. Biobanks that measure diverse environmental exposures alongside genotypes and phenotypes at scale enable systematic study of gene-environment (G×E) inte...

SPINK1-COL18A1 crosstalk shapes epigenome and drives cancer stemness in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with an increasing incidence and extremely dismal prognosis. Discovery and mechanistic understanding of the genetic and epigenetic drivers of PDAC is therefore of critical importance. Here, we uncover serine protease...

Effect of Fitzpatrick Skin Type Prompting on Diagnostic Accuracy in Multimodal Large Language Models: A Within-Image Experimental Study

Multimodal large language models are increasingly used for dermatologic queries, but whether Fitzpatrick skin type (FST) labels affect diagnostic accuracy is unknown. We evaluated 656 biopsy-confirmed photographs from the Diverse Dermatology Images (DDI) dataset under no-FST, DDI...

Joint-RPCA: domain-aware multi-omics integration for systems microbiology

Integrating multi-omics data is essential for microbiome research, as microbial communities are shaped by and respond to interdependent processes, including taxonomic composition, metabolite production and utilization, and gene expression. However, accurately capturing ecosystem-...

Conformal network link prediction with false discovery rate control under unstructured missingness

We propose a new method for predicting multiple missing links in partially observed networks while controlling the false discovery rate (FDR), a largely unresolved challenge in network analysis. The main difficulty lies in handling complex dependencies and unknown missing pattern...

Reliability of a Home-Based Smartphone Balance Assessment in Healthy Middle-Aged and Older Adults

Smartphone accelerometry could enable longitudinal home-based balance testing, yet its reliability across tasks and outcome measures must be established. We assessed the test–retest reliability and measurement precision of a custom smartphone balance application. Sixty-nine healt...

Laser Interstitial Thermal Therapy for Brain Tumors: A Prospective Multicenter Analysis of Patients From the LAANTERN Study

Background: Laser interstitial thermal therapy is a surgical tool used to ablate brain tumors, radiation necrosis, and epileptic foci. Data from the completed LAANTERN prospective multicenter registry (NCT02392078), containing tumor patients enrolled in the study across 25 US cen...

A Separation Logic for Parallel Time Complexity with Work and Span Credits

We present Parcas, a concurrent separation logic for verifying the parallel time complexity of fork-join programs. In order to abstract from the specifics of the machine, time complexity for parallel programs is given in terms of two metrics: the work, measuring the total number...

Study protocol for first national vasa previa perinatal registry

Vasa previa is a rare but potentially catastrophic obstetric condition characterized by unprotected fetal blood vessels over or adjacent to the internal cervical os. Although advances in prenatal ultrasound have dramatically improved neonatal survival through planned cesarean del...

Importance of Global Health Opportunities in Residency Selection Among Otolaryngology Applicants

ABSTRACT Introduction Global health has become an increasing priority in medical training. In this cross‐sectional study, we seek to evaluate the importance of a residency program's global health opportunities on otolaryngology‐head and neck surgery (OHNS) applicants' residency s...

The Echo-Chamber Trap: Symbolic Self-Completion and the Stagnation of Digital Activism

Social movements increasingly rely on digital platforms to mobilize support, raise awareness, and coordinate collective action. At the same time, however, the rise of online activism has intensified concerns regarding “slacktivism”, namely forms of symbolic and low-effort engagem...

Beyond Immediate Responses: A Systems Map of Community Factors Underlying Persistent Gun Violence in New Haven

Abstract Gun violence is a pervasive and multifaceted public health problem. This study describes a novel application of group model building—a process that centers stakeholder voices to describe a complex problem—to investigate drivers of gun violence and design community-led in...

Patterns and perceptions of supplement use among patients with plasma cell disorders

As novel treatments have improved survival in patients with plasma cell disorders (PCDs), there is a growing interest in complementary medicine (CM), particularly dietary supplements (vitamins, minerals, antioxidants, and herbs), amongst patients with cancer [ 1 ]. Multiple myelo...

Beyond No Alternative: IMF Asymmetrical Adjustment and African Resistance in the 1980s

This article examines how the International Monetary Fund’s (IMF) asymmetrical approach to structural adjustment in Africa became entrenched during the financial turbulence of the 1980s. Drawing upon unpublished IMF Central Files – including Executive Board minutes, internal corr...

Circulating anti-Ro/SSA-antibodies and risk of heart rate-corrected QT interval prolongation: a meta-analysis

Abstract Backgrounds Accumulating evidence indicates that anti-Ro/Sjögren’s syndrome-related antigen A(SSA)-antibodies, specifically the anti-Ro/SSA-52kD subtype, can promote heart rate-corrected QT interval(QTc) prolongation by inhibiting the hERG-K+ channel. However, the numero...

Unified framework for efficiently computable quantum circuits

Quantum circuits consisting of Clifford and matchgates are two classes of circuits that are known to be efficiently simulatable on a classical computer. We introduce a unified framework that shows in a transparent way the special structure that allows these circuits to be efficie...

Redefining Progression in a Rapidly Evolving Therapeutic Landscape

This Viewpoint the regulatory problem of how to design clean trials that regulators seek as the field of oncology becomes more therapeutically sophisticated.